Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mohamed Reda Keddar"'
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background The crosstalk between cancer and the tumour immune microenvironment (TIME) has attracted significant interest in the latest years because of its impact on cancer evolution and response to treatment. Despite this, cancer-specific t
Externí odkaz:
https://doaj.org/article/03a784654a024680ae6d6bfa9be78177
Autor:
Ross Stewart, Mark Cobbold, Scott Hammond, Sajan Khosla, Roy Rabbie, Douglas C Palmer, Mohamed Reda Keddar, Sebastian Carrasco Pro, Kathleen Burke, Ana Stewart, Benjamin Sidders, Jonathan R Dry, Martin L Miller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/eaffebbcc642413aa23369a36f3f84cf
Autor:
Michele Bortolomeazzi, Lucia Montorsi, Damjan Temelkovski, Mohamed Reda Keddar, Amelia Acha-Sagredo, Michael J. Pitcher, Gianluca Basso, Luigi Laghi, Manuel Rodriguez-Justo, Jo Spencer, Francesca D. Ciccarelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Current high-dimension imaging data analysis methods are technology-specific and require multiple tools, restricting analytical scalability and result reproducibility. Here the authors present SIMPLI, a software that overcomes these limitations for s
Externí odkaz:
https://doaj.org/article/1fa5562be7814b96821061d920d46143
Autor:
Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer d
Externí odkaz:
https://doaj.org/article/4b436b928b4743e792fdece120c80bb3
Autor:
Francesca D. Ciccarelli, Patrick Davis, Karen Ambrose, Amy Strange, Lisa Dressler, Dimitra Repana, Michele Bortolomeazzi, Joel Nulsen, Marc Pollit, Amelia Acha-Sagredo, Jacki Goldman, Hrvoje Misetic, Giulia Sartini, Neshika Wijewardhane, Lucia Montorsi, Mohamed Reda Keddar
Genetic alterations of somatic cells can drive nonmalignant clone formation and promote cancer initiation. However, the link between these processes remains unclear hampering our understanding of tissue homeostasis and cancer development. Here we col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7681654ba53c7e57f434edd9b36c5c02
https://doi.org/10.1101/2021.08.31.458177
https://doi.org/10.1101/2021.08.31.458177
Publikováno v:
KES
This paper presents a multi-objective immune memetic algorithm to the challenge of solving the Frequency Assignment Problem (FAP) in cellular networks seeking the minimization of the network’s total interference, the maximum interference and the nu
Autor:
Jo Spencer, Damjan Temelkovski, Manuel Rodriguez-Justo, Lucia Montorsi, Mohamed Reda Keddar, Gianluca Basso, Francesca D. Ciccarelli, Amelia Acha-Sagredo, Michele Bortolomeazzi, Michael J. Pitcher, Laghi L
Multiplexed imaging technologies enable the study of biological tissues at single-cell resolution while preserving spatial information. Currently, high-dimension imaging data analysis is technology-specific and requires multiple tools, restricting an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f119ec6c1870ded35ebe2fcf1bef02
https://doi.org/10.1101/2021.04.01.437886
https://doi.org/10.1101/2021.04.01.437886
Autor:
Elisa Fontana, Maise Al Bakir, Patty Wai, Lorena Benedetti, Michele Bortolomeazzi, Charles Swanton, Nedyalko Petrov, Johannes Kohl, Damjan Temelkovski, Manuel Rodriguez-Justo, Peter J. Parker, Banafshé Larijani, Jo Spencer, Francesca D. Ciccarelli, Katrina Todd, Robert L. Goldstone, Amelia Acha-Sagredo, Susan D. John, Lucia Montorsi, Mohamed Reda Keddar, Kai Keen Shiu, Victoria Kunene, Hendrik Tobias Arkenau, Tamara Denner, Gareth A. Wilson, Sophia Ward, Emma Nye, James Miles, Subin Choi
Publikováno v:
Gastroenterology
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi. Archivo Digital para la Docencia y la Investigación
instname
Background & Aims Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer tissue and associated tumor m
Autor:
Lucia Montorsi, Mohamed Reda Keddar, Gareth A. Wilson, Elisa Fontana, Subin Choi, Damjan Temelkovski, Sophia Ward, Robert L. Goldstone, Nedyalko Petrov, Peter J. Parker, Banafshé Larijani, Victoria Kunene, Kai-Keen Shiu, Tamara Denner, Katrina Todd, Amelia Acha-Sagredo, Michele Bortolomeazzi, Francesca D. Ciccarelli, Maise Al Bakir, Patty Wai, Lorena Benedetti, Jo Spencer, Jonny Kohl, Emma Nye, James Miles, Hendrik-Tobias Arkenau, Charles Swanton, Susan D. John, Manuel Rodriguez-Justo
Colorectal cancers (CRCs) show variable response to immune checkpoint blockade, which can only partially be explained by the variability of tumour mutational burden. To dissect the cellular and molecular determinants of response we performed a multi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78dfe954555fbcf646868e5cf7a640ee
https://doi.org/10.1101/2020.12.15.422831
https://doi.org/10.1101/2020.12.15.422831
Publikováno v:
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Interactions between cancer cells and non-cancer cells composing the tumour microenvironment play a primary role in determining cancer progression and shaping the response to therapy. The qualitative and quantitative characterisation of the different