Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mohamed Machwate"'
Autor:
Marc Labelle, Nicolas Lachance, Sevgi B. Rodan, G. Seedor, Michel Gallant, Kathleen M. Metters, Mohamed Machwate, Chi-Tai Leu, Deborah A. Slipetz, S. Hutchins, Nicole Sawyer, Gideon A. Rodan, Shun-ichi Harada, Robert N. Young
Publikováno v:
Molecular Pharmacology. 60:36-41
Prostaglandin (PG) E(2) is a potent inducer of cortical and trabecular bone formation in humans and animals. Although the bone anabolic action of PGE(2) is well documented, the cellular and molecular mechanisms that mediate this effect remain unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6281489af0fff51cbdc5da6ba90f6e
https://doi.org/10.1124/mol.60.1.36
https://doi.org/10.1124/mol.60.1.36
Publikováno v:
Bone. 28:275-281
Prostaglandins E (especially PGE 2 ) stimulate bone formation and increase bone mass in several species including man. The mechanism for this effect, the target cells, and the receptors involved are not known. Specific cell-surface receptors for PGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e18ade4b3d254d9c62029408adf2e1
https://doi.org/10.1016/s8756-3282(00)00447-6
https://doi.org/10.1016/s8756-3282(00)00447-6
Autor:
Sylvie Renault, Erik Zerath, Pierre J. Marie, Bruno Farbos, Jean-Marie Mouillon, Mohamed Machwate, Catherine André, Xavier Holy
Publikováno v:
Life Sciences. 61:2397-2406
Growth plate width and cartilage organization are altered during skeletal unloading in growing rats. Immunohistochemical studies have identified TGF-beta in calcified cartilage, and TGF-beta is known to induce mitogenic effects on chondrocytes in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa2c3ed150c1c3c852802bef5a32da6
https://doi.org/10.1016/s0024-3205(97)00957-0
https://doi.org/10.1016/s0024-3205(97)00957-0
Autor:
Pierre J. Marie, M. Hott, Danielle Godet, Mohamed Machwate, Erik Zerath, Xavier Holy, Abderrahim Lomri
Publikováno v:
Journal of Clinical Investigation. 96:1245-1253
We investigated the effect of recombinant human transforming growth factor beta 2 (rhTGF-beta 2) administration on trabecular bone loss induced by unloading in rats. Hind limb suspension for 14 d inhibited bone formation and induced osteopenia as sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc03ecabd103c5ee2ab590ed293306fe
https://doi.org/10.1172/jci118158
https://doi.org/10.1172/jci118158
Publikováno v:
Molecular Endocrinology. 9:187-198
We investigated the contribution of c-fos protooncogene in the mitogenic effect of transforming growth factor-beta (TGF beta) in serum-deprived, confluent rat calvaria osteoblastic cells. The TGF beta-induced growth in these cells was associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dbba09c60e7010a6689346f5d50277
https://doi.org/10.1210/mend.9.2.7776969
https://doi.org/10.1210/mend.9.2.7776969
Autor:
Erik Zerath, Dominique Modrowski, Pierre J. Marie, Xavier Holy, M. Hott, Mohamed Machwate, A. Malouvier
Publikováno v:
ResearcherID
The effects of skeletal unloading on osteoblastic cells were evaluated in tail-suspended rats. Hindlimb elevation for 14 days induced osteopenia, decreased histomorphometric indexes of bone formation in tibial metaphysis, and reduced plasma osteocalc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb792f3292cb869f85d5176347e3330
https://doi.org/10.1152/ajpendo.1993.264.5.e790
https://doi.org/10.1152/ajpendo.1993.264.5.e790
Publikováno v:
Prostaglandins, leukotrienes, and essential fatty acids. 75(2)
Prostaglandin E(2) (PGE(2)) is bone-anabolic, i.e. stimulates bone formation and increases bone mass. In this study, we explored possible intracellular mechanisms of its increase of osteogenic cells in rat bone marrow. Adherent rat bone marrow cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811cf292d7a40ef5d856dbe95eb40933
https://pubmed.ncbi.nlm.nih.gov/16890416
https://pubmed.ncbi.nlm.nih.gov/16890416
Publikováno v:
Molecular pharmacology. 54(1)
Prostaglandin E stimulates bone formation in humans and animals, and increases intracellular cAMP in osteoblastic cells. We found that cAMP inhibits apoptosis in osteoblastic cells, and examined the mechanism of this effect. We report that the cAMP e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696529984799a6234668477d2520526d
https://pubmed.ncbi.nlm.nih.gov/9658191
https://pubmed.ncbi.nlm.nih.gov/9658191
Publikováno v:
Journal of cellular biochemistry. 57(1)
To delineate the implication of c-fos protooncogenic in the osteogenie process, we have investigated the temporal pattern of c-fos mRNA expression in fetal and neonatal rat bone during intramembranous and endochondral bone formation. Northern blot an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507e3f4a22cdcecc09e8854afcb34315
https://pubmed.ncbi.nlm.nih.gov/7721959
https://pubmed.ncbi.nlm.nih.gov/7721959
Publikováno v:
Endocrinology. 134(3)
We previously found that the inhibition of bone formation and trabecular osteopenia induced by skeletal unloading in rats are associated with reduced proliferation of osteoblastic cells lining the bone surface. In this study, we examined the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77347350101b9707a0748c48775107fe
https://pubmed.ncbi.nlm.nih.gov/8119139
https://pubmed.ncbi.nlm.nih.gov/8119139