An efficient methodological approach for synthesis of selenopyridines: generation, reactions, anticancer activity, EGFR inhibitory activity and molecular docking studies.

Autor: Hussein BRM; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt. bahgat.ramadan@yahoo.com., El-Saghier SMM; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt., Allam RM; Pharmacology Department, National Research Centre, Giza, 11865, Egypt., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt., Amer AA; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt. amer_chem@yahoo.com.

Publikováno v: Molecular diversity [Mol Divers] 2024 May 13. Date of Electronic Publication: 2024 May 13.

Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities.

Autor: Ahmed AHH; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg., Allam RM; Pharmacology Department, Medical Research Institute, National Research Centre, 12622 Dokki, Cairo, Egypt., Nafady A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Mohamed SK; Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 6GD, England., Gouda AE; CIDS, The British University in Egypt, Cairo, Egypt., Beshr EAM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: mamdouhfawzy3@yahoo.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106171. Date of Electronic Publication: 2022 Sep 22.

Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors.

Autor: Bass AKA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt., Nageeb EM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., El-Zoghbi MS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt., Badr M; Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt., Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt. Electronic address: gamal.aborahma@mu.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Feb; Vol. 119, pp. 105564. Date of Electronic Publication: 2021 Dec 16.

Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction.

Autor: Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt., Almalki AJ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Allam RM; Pharmacology Department, National Research Centre, Cairo, Egypt., Althagafi A; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Md S; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1067-1078.

Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.

Autor: Hofny HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt., Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia., Abdel-Aziz SA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61519, Egypt., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bahaa.youssif@pharm.aun.edu.eg., El-Koussi NA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61519, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: nawal.abdelhalim@pharm.aun.edu.eg., Aboraia AS; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: ahmed.mohamed15@pharm.au.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104920. Date of Electronic Publication: 2021 Apr 19.