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pro vyhledávání: '"Mohamed M. S. Hamoud"'
Autor:
Nermine A. Osman, Hanan A. Abdel-Fattah, Balaram Ghosh, Yamini Bobde, Amany M. Ghanim, Sravani Pulya, Abdalla E. A. Hassan, Mohamed M. S. Hamoud
Publikováno v:
New Journal of Chemistry. 44:9671-9683
Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads to unwant