Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Mohamed M. Khalifa"'
Autor:
Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee, Ahmed A. Al-Karmalawy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised. The targets and the SeNP derivatives were exam
Externí odkaz:
https://doaj.org/article/a5000753091f4c2a97400dcb0e5c3430
Autor:
Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Mohamed M. Khalifa, Mohamed S. Nafie, Mohamed A. Saleh, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was eva
Externí odkaz:
https://doaj.org/article/c4fb055b92c24a3eb4000d2f73075561
Autor:
Ashraf K. El-Damasy, Hyun Ji Kim, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Mohamed M. Khalifa, Eun-Kyoung Bang, Gyochang Keum
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 427 (2024)
Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic candidates. Herein, we have identified the first coumarin-based selective DDR1 i
Externí odkaz:
https://doaj.org/article/0df99d9f11c14b339e86b40d4ee96d20
Autor:
Mohammed S. Taghour, Hazem A. Mahdy, Maher H. Gomaa, Ahmed Aglan, Mahmoud Gomaa Eldeib, Alaa Elwan, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Mohamed M. Khalifa, Ibrahim H. Eissa, Hazem Elkady
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2063-2077 (2022)
In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and M
Externí odkaz:
https://doaj.org/article/f180310e302d49f29cd0dbeea3e88d77
Autor:
Hazem Elkady, Alaa Elwan, Hesham A. El-Mahdy, Ahmed S. Doghish, Ahmed Ismail, Mohammed S. Taghour, Eslam B. Elkaeed, Ibrahim H. Eissa, Mohammed A. Dahab, Hazem A. Mahdy, Mohamed M. Khalifa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 403-416 (2022)
A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and Hep
Externí odkaz:
https://doaj.org/article/67393c5d353040d2a6882e7cf732c5b3
Autor:
Reda G. Yousef, Albaraa Ibrahim, Mohamed M. Khalifa, Wagdy M. Eldehna, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Eslam B. Elkaeed, Aisha A. Alsfouk, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1389-1403 (2022)
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against V
Externí odkaz:
https://doaj.org/article/8d0e025758924bbe9f7388baf0e479e8
Autor:
Mohamed M. Khalifa, Ahmed A. Al-Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa, Hazem A. Mahdy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 299-314 (2022)
This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed
Externí odkaz:
https://doaj.org/article/ae088b0644544fc2a2e4c316d2acc944
Autor:
Hayaa M. Alhuthali, Mazen Almehmadi, Eman F. Ataya, Hind A. Alzahrani, Amani A. Alrehaili, Maha M. Bakhuraysah, Fouzeyyah Ali Alsaeedi, Ahad Amer Alsaiari, Mohamed M. Khalifa, Amal F. Gharib
Publikováno v:
European Journal of Inflammation, Vol 21 (2023)
Background: Hyperglycemic patients are at a high risk of COVID-19 severity. Neutrophils have been considered critical effector cells in COVID-19 development. Vitamin D deficiency is prevalent in hyperglycemic patients and was found to adversely assoc
Externí odkaz:
https://doaj.org/article/59e6b059fe6f4cdba8622d1e884080ad
Autor:
Eslam B. Elkaeed, Mohamed M. Khalifa, Bshra A. Alsfouk, Aisha A. Alsfouk, Abdul-Aziz M. M. El-Attar, Ibrahim H. Eissa, Ahmed M. Metwaly
Publikováno v:
Metabolites, Vol 12, Iss 11, p 1122 (2022)
Four compounds, hippacine, 4,2′-dihydroxy-4′-methoxychalcone, 2′,5′-dihydroxy-4-methoxychalcone, and wighteone, were selected from 4924 African natural metabolites as potential inhibitors against SARS-CoV-2 papain-like protease (PLpro, PDB ID
Externí odkaz:
https://doaj.org/article/57002e0c23334214a04bee65e5410bf6
Autor:
Eslam B. Elkaeed, Reda G. Yousef, Mohamed M. Khalifa, Albaraa Ibrahim, Ahmed B. M. Mehany, Ibraheem M. M. Gobaara, Bshra A. Alsfouk, Wagdy M. Eldehna, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed Ayman El-Zahabi
Publikováno v:
Molecules, Vol 27, Iss 19, p 6203 (2022)
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric essential features to bind correctly with the VEGFR-2 active pocket. All members were evaluated f
Externí odkaz:
https://doaj.org/article/24f5a628f6624dcb95882eb504fbf8fc