Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Mohamed M. Hefnawy"'
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy, Claudiu T. Supuran
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 12, Pp 101866- (2023)
In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22. Quina
Externí odkaz:
https://doaj.org/article/1b543ab78ca8435c914ea8a96d403b3f
Autor:
Abdulaziz I. Alnasser, Mohamed M. Hefnawy, Abdullah M. Al-Hossaini, Yousef A. Bin Jardan, Adel S. El-Azab, Alaa M. Abdel-Aziz, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan, Mohamed W. Attwa, Manal A. El-Gendy
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 9, Pp 101693- (2023)
This study developed a novel, sensitive and selective LC-MS/MS method for the concurrent determination of DCB and VTX in rat plasma using encorafenib as internal standard (IS). To identify DCB, VTX, and IS, the positive multiple reaction monitoring (
Externí odkaz:
https://doaj.org/article/cc770f7b22b14d4b83f8f2adb865c09a
Autor:
Salma Fares, Khalid B. Selim, Fatma E. Goda, Magda A. A. El-Sayed, Nawaf A. AlSaif, Mohamed M. Hefnawy, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1487-1498 (2021)
New cyanobenzofurans derivatives 2–12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC50 = 4.17–8.87 and 5.5–11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activit
Externí odkaz:
https://doaj.org/article/19de139e6b954a888b332ef01aceb363
Autor:
Mohamed M. Hefnawy, Mohamed W. Attwa, Adeeba A. Alzamil, Manal A. El-Gendy, Adel S. El-Azab, Yousef A. Bin Jardan, Ali A. El-Gamal
Publikováno v:
Molecules, Vol 28, Iss 4, p 1553 (2023)
LE300 is a novel dopamine receptor antagonist used to treat cocaine addiction. In the current study, a sensitive and fast liquid chromatography–tandem mass spectrometry (LC-MS/MS) has been established and validated for the simultaneous analysis of
Externí odkaz:
https://doaj.org/article/ec9f4e8cc6d34da8945cdb177fe89c30
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 598-609 (2020)
Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficien
Externí odkaz:
https://doaj.org/article/c29c31e8ad2a48d699922a94da505129
Autor:
Mohamed M. Hefnawy, Mohammed M. Alanazi, Abdullah M. Al-Hossaini, Abdulaziz I. Alnasser, Adel S. El-Azab, Yousef A. Bin Jardan, Mohamed W. Attwa, Manal A. El-Gendy
Publikováno v:
Molecules, Vol 28, Iss 1, p 79 (2022)
The combination regimen targeting BRAF and MEK inhibition, for instance, encorafenib (Braftovi™, ENF) plus binimetinib (Mektovi®, BNB), are now recommended as first-line treatment in patients with unresectable or metastatic melanoma with a BRAF V6
Externí odkaz:
https://doaj.org/article/a2d37e0a23624ef68179175e33bc6fe2
Autor:
Mostafa S. Mohammed, Mohamed M. Hefnawy, Abdulrhman A. Al-Majed, Haitham K. Alrabiah, Nasser A. Algrain, Ahmad J. Obaidullah, Abdulmalik S. Altamimi, Yousef A. Bin Jardan, Abdullah M. Al-Hossaini
Publikováno v:
Molecules, Vol 26, Iss 7, p 2091 (2021)
A novel, fast and sensitive enantioselective HPLC assay with a new core–shell isopropyl carbamate cyclofructan 6 (superficially porous particle, SPP) chiral column (LarihcShell-P, LSP) was developed and validated for the enantiomeric separation and
Externí odkaz:
https://doaj.org/article/c2e9d2c140754f2bba77c5f639358ea9
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2566-o2566 (2012)
In the title compound, C19H15N4+·Br−·C2H5OH, the tetrazole ring makes dihedral angles of 57.44 (9), 50.92 (9) and 4.65 (8)° with the attached phenyl rings. In the crystal, the cation and the anion are linked to each other by intermolecular C—H
Externí odkaz:
https://doaj.org/article/ed2d546fd9ea43a39f78f81468bc2111
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2567-o2567 (2012)
In the title salt, C19H15N4+·C24H20B−, the tetraphenylborate anion is in a tetrahedral geometry around the B atom [C—B—C angles of 107.10 (9)–111.79 (9)°]. In the cation, the tetrazole ring makes dihedral angles of 3.04 (7), 51.75 (7) and 5
Externí odkaz:
https://doaj.org/article/7a5394d282d64e70a627e1dd8939d4ed
Autor:
Mohamed M. Hefnawy, Maha M AbouEl-Alamin, Adnan A. Kadi, Yousef A. Bin Jardan, Sherif F. Hammad, Abdullah M. Al-Hossaini, Mostafa Mohammed, Mohamed W. Attwa, Nawaf A. Alsaif
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 11, Pp 8160-8171 (2020)
HCV-genotype-4 (HCV-GT4) is the cause of approximately 20% of the 170 million cases of chronic hepatitis C virus (HCV) in the world. Around 95% of patients with chronic HCV infection can be cure by utilizing direct-acting antiviral treatment. Two ant