Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mohamed M. Elsebaei"'
Autor:
Ahmed K. B. Aljohani, Waheed Ali Zaki El Zaloa, Mohamed Alswah, Mohamed A. Seleem, Mohamed M. Elsebaei, Ashraf H. Bayoumi, Ahmed M. El-Morsy, Mohammed Almaghrabi, Aeshah A. Awaji, Ali Hammad, Marwa Alsulaimany, Hany E. A. Ahmed
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 15026 (2023)
Phenylpyrazolo[3,4-d]pyrimidine is considered a milestone scaffold known to possess various biological activities such as antiparasitic, antifungal, antimicrobial, and antiproliferative activities. In addition, the urgent need for selective and poten
Externí odkaz:
https://doaj.org/article/0a56b615b6774e4a8133efe02789d5b2
Autor:
Mariam Omara, Marwa Alhashimi, Humaira Gowher, Noha M. Elhosseiny, Abdelrahman S. Mayhoub, Mark I Gutay, Ahmed S. Attia, Allison B. Norvil, Nader S. Abutaleb, Mohamed M. Elsebaei, Tamer M. Abdelghany, Mohamed Hagras, Mohamed N. Seleem
Publikováno v:
ACS Infectious Diseases. 6:2887-2900
Exploring the structure-activity relationship (SAR) at the cationic part of arylthiazole antibiotics revealed hydrazine as an active moiety. The main objective of the study is to overcome the inherited toxicity associated with the free hydrazine. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f237bfaa58b9457f61fa4bc8f368f7f2
https://doi.org/10.1021/acsinfecdis.0c00137
https://doi.org/10.1021/acsinfecdis.0c00137
Autor:
Mohamed M. Elsebaei, Ahmed Mancy, Abdelrahman S. Mayhoub, Abdullah Y. Saad, Mohamed N. Seleem, Jelan A. Abdel-Aleem, Nader S. Abutaleb, Ahmed Kotb, Alsagher O. Ali, Haroon Mohammad
Publikováno v:
ACS Infectious Diseases. 6:80-90
Bacterial resistance to antibiotics is presently one of the most pressing healthcare challenges and necessitates the discovery of new antibacterials with unique chemical scaffolds. However, the determination of the optimal balance between structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0c82fc5b347da35441cf490d769303
https://doi.org/10.1021/acsinfecdis.9b00211
https://doi.org/10.1021/acsinfecdis.9b00211
Autor:
Sammar A. Bayoumi, Alsagher O. Ali, Abdelrahman S. Mayhoub, Ali Hammad, Allison B. Norvil, Nader S. Abutaleb, Mohamed Alswah, Mohamed N. Seleem, Mohamed M. Elsebaei, Abdelaziz Alattar, Jelan A. Abdel-Aleem, Humaira Gowher
Publikováno v:
Journal of Medicinal Chemistry. 62:7998-8010
The narrow antibacterial spectrum of phenylthiazole antibiotics was expanded by replacing central thiazole with a pyrazole ring while maintaining its other pharmacophoric features. The most promising derivative, compound 23, was more potent than vanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3278e00770abb2d16de2166080b5cd
https://doi.org/10.1021/acs.jmedchem.9b00720
https://doi.org/10.1021/acs.jmedchem.9b00720
Autor:
Amie R Michie, Mahmoud M. Abd Rabo Moustafa, Mohamed N. Seleem, Haroon Mohammad, Humaira Gowher, Mohamed M. Elsebaei, Abdelrahman S. Mayhoub, Hebatallah Samy, Amgad Samir, Allison B. Norvil, Nader S. Abutaleb
Publikováno v:
European Journal of Medicinal Chemistry. 175:49-62
Antibiotic resistance remains a pressing medical challenge for which novel antibacterial agents are urgently needed. The phenylthiazole scaffold represents a promising platform to develop novel antibacterial agents for drug-resistant infections. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6628e97e6162243f718995731a412e
https://doi.org/10.1016/j.ejmech.2019.04.063
https://doi.org/10.1016/j.ejmech.2019.04.063
Publikováno v:
RSC Advances. 9:28171-28185
The discovery of 3rd and 4th generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae43c12f0b0012e7ed926e41e7d85fb
https://doi.org/10.1039/c9ra04518j
https://doi.org/10.1039/c9ra04518j
Autor:
Mohamed, Hagras, Nader S, Abutaleb, Noha M, Elhosseiny, Tamer M, Abdelghany, Mariam, Omara, Mohamed M, Elsebaei, Marwa, Alhashimi, Allison B, Norvil, Mark I, Gutay, Humaira, Gowher, Ahmed S, Attia, Mohamed N, Seleem, Abdelrahman S, Mayhoub
Publikováno v:
ACS infectious diseases. 6(11)
Exploring the structure-activity relationship (SAR) at the cationic part of arylthiazole antibiotics revealed hydrazine as an active moiety. The main objective of the study is to overcome the inherited toxicity associated with the free hydrazine. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97acb660a70757d567f20beba262e151
https://pubmed.ncbi.nlm.nih.gov/32897045
https://pubmed.ncbi.nlm.nih.gov/32897045
Autor:
Haroon Mohammad, Jianan Zhang, Lu Chen, Satish R. Malwal, Mohamed M. Elsebaei, Nader S. Abutaleb, Youssef A. Hegazy, Adel Ghiaty, Abdelrahman S. Mayhoub, Mohamed Abouf, Eric Oldfield, Mohamed N. Seleem
Publikováno v:
European Journal of Medicinal Chemistry. 148:195-209
The promising activity of phenylthiazoles against multidrug-resistant bacterial pathogens, in particular MRSA, has been hampered by their limited systemic applicability, due to their rapid metabolism by hepatic microsomal enzymes, resulting in short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17626f4d69f49654bd0a414d9f48060d
https://doi.org/10.1016/j.ejmech.2018.02.031
https://doi.org/10.1016/j.ejmech.2018.02.031
Autor:
Mohamed N. Seleem, Haroon Mohammad, Mohamed Hagras, Abdelrahman S. Mayhoub, Christine E. Peters, Mohamed M. Elsebaei, Kit Pogliano, Youssef A. Hegazy, Bruce A. Cooper, Hamada S. Abulkhair, Joe Pogliano, Islam Eid
Publikováno v:
European Journal of Medicinal Chemistry. 139:665-673
The promising antibacterial potency of arylthiazole antibiotics is offset by their limited activity against intracellular bacteria (namely methicillin-resistant Staphylococcus aureus (MRSA)), similar to many clinically-approved antibiotics. The failu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a04f599b909d963b67b38cb2c68c65
https://doi.org/10.1016/j.ejmech.2017.08.039
https://doi.org/10.1016/j.ejmech.2017.08.039
Autor:
Abdulrahman A. Mahgoub, Nader S. Abutaleb, Mohamed M. Elsebaei, Haroon Mohammad, Abdelrahman S. Mayhoub, Mohamed Hagras, Daoyi Li, Mohamed N. Seleem
Publikováno v:
European journal of medicinal chemistry. 182
A novel series of phenylthiazoles bearing cyclic amines at the phenyl-4 position was prepared with the objective of decreasing lipophilicity and improving the overall physicochemical properties and pharmacokinetic profile of the compounds. Briefly, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2579760cd0e6e3d09a367e6ff65b48a
https://pubmed.ncbi.nlm.nih.gov/31446245
https://pubmed.ncbi.nlm.nih.gov/31446245