Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mohamed Koukni"'
Autor:
Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J. Snijder, Martijn J. van Hemert, Frank van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De Jonghe, Arnaud Marchand
Publikováno v:
Molecules, Vol 27, Iss 3, p 1052 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has led to a pandemic, that continues to be a huge public health burden. Despite the availability of vaccines, there is still a need for small-molecule
Externí odkaz:
https://doaj.org/article/e3ecdfeabd414d40b446f2e5c206a3fd
Autor:
Michael McNaughton, Mohamed Koukni, Wim Smets, Patrick Chaltin, Dorothée Bardiot, Suzanne J.F. Kaptein, Gunter Carlens, Kai Dallmeier, Arnaud Marchand, Johan Neyts
Publikováno v:
Journal of Medicinal Chemistry. 61:8390-8401
3-Acyl-indole derivative 1 was identified as a novel dengue virus (DENV) inhibitor from a DENV serotype 2 (DENV-2) phenotypic antiviral screen. Extensive SAR studies led to the discovery of new derivatives with improved DENV-2 potency as well as acti
Autor:
Dorothée Bardiot, Patrick Chaltin, Dirk Jochmans, Mohamed Koukni, Mieke Boon, Carmen Mirabelli, Johan Neyts, Arnaud Marchand, Martine Jaspers, Mark Jorissen
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:1823-1829
OBJECTIVES: We report the use of reconstituted 3D human airway epithelium cells (HuAECs) of bronchial origin in an air-liquid interface to study respiratory syncytial virus (RSV) infection and to assess the efficacy of RSV inhibitors in (pre-)clinica
Autor:
Mieke Boon, Mark Jorissen, Patrick Chaltin, Dorothée Bardiot, Dirk Jochmans, Mohamed Koukni, Johan Neyts, Martine Jaspers, Carmen Mirabelli, Arnaud Marchand
We report the use of reconstituted 3D-human airway epithelium cells of bronchial origin (HuAEC) in an air-liquid interface to study respiratory syncytial virus (RSV) infection and to assess the efficacy of RSV inhibitors in (pre-)clinical development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969fc368555d5e43399381106d629037
Autor:
Bart Medaer, Yolande Lang, Mohamed Koukni, Stef Leurs, Georges J. Hoornaert, Hua Mao, Suzanne Toppet, Frans Compernolle, Thierry Brossette, Tomasz Kozlecki, Michel Guillaume
Publikováno v:
European Journal of Organic Chemistry. 2006:1586-1592
Aldol condensation of 8-fluoro-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one and (4S)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde provides access to the corresponding (E,Z)-α,β-unsaturated ketones with a (4R)-chiral 11-substituent. Subsequent hydro
Publikováno v:
Tetrahedron Letters. 43:8697-8700
Autor:
Hendrik Jan Thibaut, Javier Martin, Johan Neyts, Mohamed Koukni, Steve Oberste, Aloys Tijsma, Stéphane Spieser, Eric Rhoden, Gerhard Pürstinger, Pieter Leyssen, Antonia Volny-Luraghi, Patrick Chaltin, Armando M. De Palma, Arnaud Marchand
Publikováno v:
Antiviral research. 110
A novel small molecule, H1PVAT, was identified as a potent and selective inhibitor of the in vitro replication of all three poliovirus serotypes, whereas no activity was observed against other enteroviruses. Time-of-drug-addition studies revealed tha