Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mohamed Izikki"'
Autor:
Benoît Gore, Mohamed Izikki, Olaf Mercier, Laurence Dewachter, Elie Fadel, Marc Humbert, Philippe Dartevelle, Gerald Simonneau, Robert Naeije, Franck Lebrin, Saadia Eddahibi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100310 (2014)
Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH). To determine whether the TGF-β/ALK1/ENG pathwa
Externí odkaz:
https://doaj.org/article/59d6672fcbf84296bf599c84e357b580
Autor:
Mohamed Izikki, Olaf Mercier, Florence Lecerf, Lauriane Lubert Guin, Eric Hoang, Peter Dorfmüller, Frédéric Perros, Marc Humbert, Gerald Simonneau, Philippe Dartevelle, Elie Fadel, Saadia Eddahibi
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77073 (2013)
BACKGROUND:Pulmonary hypertension (PH) is a progressive disorder characterized by an increase in pulmonary artery pressure and structural changes in the pulmonary vasculature. Several observations indicate that growth factors play a key role in PH by
Externí odkaz:
https://doaj.org/article/9c7f01bd72bb436195ef88eff1d0080e
Autor:
Serge Adnot, Claude C. Abbou, François Giuliano, Jacques Bernabé, Papa Ahmed Fall, Saadia Eddahibi, Salem Swieb, Mohamed Izikki, Rachid Souktani, L. Tu, René Yiou
Publikováno v:
European Urology. 56:716-726
Objectives To investigate the pathophysiology of postprostatectomy erectile dysfunction (pPED) in a rat model of bilateral cavernous nerve ablation (BCNA) and to assess the effects of local bone marrow mononuclear cell (BMMNC) injection on erectile d
Autor:
Christophe Guilluy, Saadia Eddahibi, Marc Humbert, Elie Fadel, Gervaise Loirand, Mohamed Izikki, Pierre Pacaud, Laurent Savale, Christophe Guignabert, Ly Tu, Serge Adnot, Christian Agard
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 179:1151-1158
The complex and multifactorial pathogenesis of pulmonary hypertension (PH) involves constriction, remodeling, and in situ thrombosis of pulmonary vessels. Both serotonin (5-HT) and Rho kinase signaling may contribute to these alterations.To investiga
Autor:
Armin Hatzelmann, Degenhard Marx, Bernadette Raffestin, Hermann Tenor, Patricia Zadigue, Juergen Klar, Mohamed Izikki, Saadia Eddahibi, Serge Adnot
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:54-62
Phosphodiesterase type 4 (PDE4) is involved in the hydrolysis of cAMP in pulmonary vascular smooth muscle (PA-SMC) and immune inflammatory cells. Given that intracellular cAMP accumulation inhibits contraction and growth of PA-SMCs as well as inflamm
Autor:
Saadia Eddahibi, Gérald Simonneau, Philippe Jourdon, Chris Happé, Sana Bentebbal, Harm Jan Bogaard, Benoit Ranchoux, Elie Fadel, Florence Lecerf, Marc Humbert, Fabrice Antigny, Peter Dorfmüller, Mohamed Izikki, Frédéric Perros
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 7(2)
Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting vasoconstriction, smooth muscle proliferation and inflammation. Objectives This study sought to test the hypothe
Autor:
Serge Adnot, David M. Rodman, Saadia Eddahibi, Naïma Hanoun, Christophe Guignabert, Anne-Marie Barlier-Mur, Patricia Zadigue, Mohamed Izikki, Zhenlin Li, Ly Tu, Michel Hamon
Publikováno v:
Circulation Research. 98:1323-1330
One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative response to internalized serotonin (5-HT) caused by increased expression of the 5-HT transpor
Autor:
Marc Humbert, Elie Fadel, Olaf Mercier, Eric Hoang, Saadia Eddahibi, Florence Lecerf, Christophe Guignabert, Win-Yan Liu, Peter Dorfmüller, Arturo Londoño-Vallejo, Lilia Lamrani, Mohamed Izikki, Irena Draskovic
Publikováno v:
Journal of the American College of Cardiology
Journal of the American College of Cardiology, 2015, 66 (17), pp.1942-1943. ⟨10.1016/j.jacc.2015.08.869⟩
Journal of the American College of Cardiology, Elsevier, 2015, 66 (17), pp.1942-1943. ⟨10.1016/j.jacc.2015.08.869⟩
Journal of the American College of Cardiology, 2015, 66 (17), pp.1942-1943. ⟨10.1016/j.jacc.2015.08.869⟩
Journal of the American College of Cardiology, Elsevier, 2015, 66 (17), pp.1942-1943. ⟨10.1016/j.jacc.2015.08.869⟩
Idiopathic pulmonary arterial hypertension (iPAH) is a rare disease that occurs sporadically and in which pulmonary arterial pressure elevation leads to right heart failure and death. Although the fundamental causes remain elusive, vascular remodelin
Autor:
Saadia Eddahibi, Franck Lebrin, Olaf Mercier, Robert Naeije, Mohamed Izikki, Philippe Dartevelle, Benoit Gore, Elie Fadel, Marc Humbert, Gérald Simonneau, Laurence Dewachter
Publikováno v:
PLoS ONE
PloS one, 9 (6
PLoS ONE, Vol 9, Iss 6, p e100310 (2014)
PloS one, 9 (6
PLoS ONE, Vol 9, Iss 6, p e100310 (2014)
Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH). To determine whether the TGF-β/ALK1/ENG pathwa
Autor:
Serge Adnot, Marc Humbert, Christophe Guignabert, Saadia Eddahibi, Elie Fadel, Patricia Zadigue, Laurence Dewachter, Mohamed Izikki, Ly Tu
Publikováno v:
A26. SMOOTH MUSCLE CELLS IN PULMONARY ARTERIAL HYPERTENSION: REGULATION, DIFFERENTIATION, AND PROLIFERATION.