Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mohamed Hadjeri"'
Autor:
Ahcène Boumendjel, Anne-Marie Mariotte, Mohamed Hadjeri, Xavier Ronot, Jean Boutonnat, Magali Barbier
Publikováno v:
Journal of Medicinal Chemistry. 46:2125-2131
Flavonoid derivatives were synthesized and tested for their ability to modulate P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in vitro. These compounds belong to various flavonoid subclasses, namely: chromones, azaisoflavones, and aurones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49faec40e9833fbafc03bc7017ad6cd3
https://doi.org/10.1021/jm021099i
https://doi.org/10.1021/jm021099i
Publikováno v:
Chem. Pharm. Bull.
Chem. Pharm. Bull., 2001, 49, pp.1352-1355
Chem. Pharm. Bull., 2001, 49, pp.1352-1355
The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686fc2a05e42c4139bdce31ff270dad6
https://doi.org/10.1248/cpb.49.1352
https://doi.org/10.1248/cpb.49.1352
Publikováno v:
ChemInform. 33
The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1104380ae08fb220587af619cb3343
https://doi.org/10.1002/chin.200212178
https://doi.org/10.1002/chin.200212178
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f226b7137f9cf5568572e3f4fb5fe315
https://doi.org/10.1002/chin.200223038
https://doi.org/10.1002/chin.200223038
Publikováno v:
Tetrahedron Letters. 41:7037-7039
The synthesis of 2-aryl-3,5,7-trimethoxy-4-quinolones was accomplished in three steps starting from 3,5-dimethoxyaniline and an aroyl chloride. These structures might be used as potential flavonol analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d04b16a222fccdacb1d2362a3fe2334f
https://doi.org/10.1016/s0040-4039(00)01226-0
https://doi.org/10.1016/s0040-4039(00)01226-0
Autor:
Mohamed Hadjeri, Eva-Laure Peiller, Martin A. Lawson, Nabajyoti Deka, Chantal Beney, Ahcène Boumendjel, Charles Dumontet
Publikováno v:
Journal of medicinal chemistry. 47(20)
We report the synthesis of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones and their biological activity as antitumor agents. These molecules were initially evaluated for their ability to induce cell cycle arrest in the G2/M phase. Compounds that showed si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13408877d240fcb40e1f9b64d51405b
https://pubmed.ncbi.nlm.nih.gov/15369401
https://pubmed.ncbi.nlm.nih.gov/15369401
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf267bde5a8babce31e80bc12d217be
https://doi.org/10.1002/chin.200342282
https://doi.org/10.1002/chin.200342282
Publikováno v:
ChemInform. 34
Activated acetophenones were deacetylated by treatment with an excess of tin(IV) chloride in 1,2-dichloroethane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd33896c708875884569c7a5964426ee
https://doi.org/10.1002/chin.200305040
https://doi.org/10.1002/chin.200305040
ChemInform Abstract: A Convenient Method for the Synthesis of 3,5,7-Trimethoxy-2-phenyl-4-quinolones
Publikováno v:
ChemInform. 31
The synthesis of 2-aryl-3,5,7-trimethoxy-4-quinolones was accomplished in three steps starting from 3,5-dimethoxyaniline and an aroyl chloride. These structures might be used as potential flavonol analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1304962f3e927bb03a66af146b336df6
https://doi.org/10.1002/chin.200048162
https://doi.org/10.1002/chin.200048162
Publikováno v:
ResearcherID
3,5-Dimethoxyaniline was acetylated and found to be a key intermediate for the synthesis of a variety of biologically active aminoflavones and quinolones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6927c39ed4e5a5932380012d50e110
https://doi.org/10.3987/com-01-9366
https://doi.org/10.3987/com-01-9366