Výsledky vyhledávání - "Mohamed H.S. Awwad"

Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity

Autor: Borhane Guezguez, Alexander Lang, Mohamed H.S. Awwad, Jean-Christophe Bourdon, Matthias Theobald, Edite Antunes Ferreira, Hakim Echchannaoui, Markus Munder, Kevin Jan Legscha, Danuta Galetzka, Gigi Nu Hoang Quy Ton, Michael Hundemer, Antonios Chamoun

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for Immunotherapy of Cancer

BackgroundTumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senesce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abc0a82e7522f0090b689feb42cadd1
https://jitc.bmj.com/content/9/6/e001846.full

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P-060: Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single cell transcriptomics

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 21:S71-S72

Background Relapsed/refractory multiple myeloma (RRMM) is characterized by a high inter- and intratumor heterogeneity and a complex interplay of myeloma cells with the bone marrow microenvironment (BME). Accordingly, there is an urgent need to dissec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9316d6d14b5bc4660773d780a1cfc901
https://doi.org/10.1016/s2152-2650(21)02194-7

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Comparison of NGS and MFC Methods: Key Metrics in Multiple Myeloma MRD Assessment

Publikováno v: Cancers, Vol 12, Iss 2322, p 2322 (2020)
Cancers
Volume 12
Issue 8

In order to meet the challenges in data evaluation and comparability between studies in multiple myeloma (MM) minimal residual disease (MRD) assessment, the goal of the current study was to provide a step-by-step evaluation of next-generation sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3069fbc3c5a12f6bb9530d5e1aaaf56f
https://www.mdpi.com/2072-6694/12/8/2322

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IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells

Autor: Hakim Echchannaoui, Eva Amman, Michael Hundemer, Julian Plaumann, Niels Halama, Brigitte Neuber, Mohamed H.S. Awwad, Marc-Steffen Raab, Hartmut Goldschmidt, Carsten Müller-Tidow, Melanie Engelhardt, Jens Hillengass

Publikováno v: Cancer Immunology, Immunotherapy. 67:1695-1707

Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8+CD28- regulatory T-cells in patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a7a7c9391ad190bb2bcb0886ef0994d
https://doi.org/10.1007/s00262-018-2230-0

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Quantification of number of CD38 sites on bone marrow plasma cells in patients with light chain amyloidosis and smoldering multiple myeloma

Autor: Katharina Kriegsmann, Mohamed H.S. Awwad, Anja Seckinger, Anthony D. Ho, Hartmut Goldschmidt, Tobias Dittrich, Carsten Müller-Tidow, Dirk Hose, Brigitte Neuber, Ute Hegenbart, Jens Hillengass, Stefan Schönland, Michael Hundemer

Publikováno v: Cytometry Part B: Clinical Cytometry. 94:767-776

BACKGROUND Recent approaches in multiple myeloma (MM) treatment have targeted CD38. As antigen expression levels on plasma cells (PCs) were demonstrated to affect response to monoclonal antibody (mAb) treatment, a precise characterization of PC pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd9f4e81f0b000446543b72b745a47a4
https://doi.org/10.1002/cyto.b.21636

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Lenalidomide overcomes the immunosuppression of regulatory CD8+CD28− T-cells

Autor: Sergej Medenhoff, Hartmut Goldschmidt, Michael Hundemer, Michael Schmitt, Melanie Engelhardt, Mathias Witzens-Harig, Mohamed H.S. Awwad, Brigitte Neuber, Anthony D. Ho, Wjahat A. Waraich, Jingying Dai

Publikováno v: Oncotarget. 8:98200-98214

// Brigitte Neuber 1, * , Jingying Dai 2, * , Wjahat A. Waraich 1 , Mohamed H.S. Awwad 1 , Melanie Engelhardt 1 , Michael Schmitt 1 , Sergej Medenhoff 1 , Mathias Witzens-Harig 1 , Anthony D. Ho 1 , Hartmut Goldschmidt 1, 3 and Michael Hundemer 1 1 D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92f09cc15fd79eff95227b9abb349c3e
https://doi.org/10.18632/oncotarget.21516

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The Bone Marrow Microenvironment of Multiple Myeloma Long-Term Survivors at Single Cell Resolution

Autor: Benedikt Brors, Raphael Lutz, Mohamed H.S. Awwad, Niels Weinhold, Hartmut Goldschmidt, Carsten Müller-Tidow, Abdelrahman Mahmoud, Simon Haas, Tobias Boch, Brian G.M. Durie, Marc S. Raab, Michael Hundemer, Charles D. Imbusch

Publikováno v: Blood. 136:32-33

To date, multiple myeloma (MM) remains an incurable disease with only a minor fraction of patients experiencing long-term remission (LTR) over 7 years after a single therapy line. Myeloma cells strongly depend on the interaction with their bone marro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9c8e1951d43b7f159acbcea6ed35c01
https://doi.org/10.1182/blood-2020-142298

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