Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mohamed H. Al-Sabri"'
Autor:
Mohamed H. Al-Sabri, Nourhane Ammar, Stanislava Korzh, Ahmed M. Alsehli, Kimia Hosseini, Robert Fredriksson, Jessica Mwinyi, Michael J. Williams, Hadi Boukhatmi, Helgi B. Schiöth
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Previously, we showed that fluvastatin treatment induces myofibrillar damage and mitochondrial phenotypes in the skeletal muscles of Drosophila. However, the sequential occurrence of mitochondrial phenotypes and myofibril damage remains elus
Externí odkaz:
https://doaj.org/article/f778552c72294911b629376c6860df04
Autor:
Mohamed H. Al-Sabri, Maryam Nikpour, Laura E. Clemensson, Misty M. Attwood, Michael J. Williams, Mathias Rask-Anderson, Jessica Mwinyi, Helgi B. Schiöth
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Monoaminergic neurotransmitter systems play a central role in neuronal function and behaviour. Dysregulation of these systems gives rise to neuropsychiatric and neurodegenerative disorders with high prevalence and societal burden, collective
Externí odkaz:
https://doaj.org/article/25cad3bf46fa4012b801ae3e40292cf9
Autor:
Ahmed M. Alsehli, Gull Rukh, Laura E. Clemensson, Diana-Maria Ciuculete, Xiao Tan, Mohamed H. Al-Sabri, Michael J. Williams, Christian Benedict, Helgi B. Schiöth
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1453-1463 (2021)
Importance: Statins have been linked to an increased risk for insomnia, but the literature is controversial. Moreover, it is unknown, if the potential effects are directly related to the inhibition of the statin target HMGCR, the subsequently lowered
Externí odkaz:
https://doaj.org/article/bfe6d94443364285abc89ac22e3862c3
Autor:
Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Mohamed H. Al-Sabri, Daniela Kročianová, Laura E. Clemensson, Mélissa Gentreau, Helgi B. Schiöth
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin users are older adults with CVD, who are also at high risk of cognitive decl
Externí odkaz:
https://doaj.org/article/c42d89c129aa46a48550b411b0eaf1af
Autor:
Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B. Schiöth
Publikováno v:
Cells, Vol 11, Iss 22, p 3528 (2022)
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general
Externí odkaz:
https://doaj.org/article/d87b7b6fdc5541df9494759d713adeac
Autor:
Michael J. Williams, Ahmed M. Alsehli, Sarah N. Gartner, Laura E. Clemensson, Sifang Liao, Anders Eriksson, Kiriana Isgrove, Lina Thelander, Zaid Khan, Pavel M. Itskov, Thiago C. Moulin, Valerie Ambrosi, Mohamed H. Al-Sabri, Francisco Alejandro Lagunas-Rangel, Pawel K. Olszewski, Helgi B. Schiöth
Publikováno v:
Cells, Vol 11, Iss 6, p 970 (2022)
The statin drug target, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), is strongly linked to body mass index (BMI), yet how HMGCR influences BMI is not understood. In mammals, studies of peripheral HMGCR have not clearly identified a role in BMI m
Externí odkaz:
https://doaj.org/article/d2ee4887765548f0a390a01cd09f5417
Autor:
Ahmed M. Alsehli, Sifang Liao, Mohamed H. Al-Sabri, Lukas Vasionis, Archana Purohit, Neha Behare, Laura E. Clemensson, Michael J. Williams, Helgi B. Schiöth
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 79 (2022)
Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events. While sleep disturbances are recognized as a side-effect of statin treatment, the impact of st
Externí odkaz:
https://doaj.org/article/34b512cac9f84cb88f0cc640210954ef
Autor:
Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Mahsa Babaei, Mohamed H. Al-Sabri, Helgi B. Schiöth
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1136 (2021)
There is no definite cure for Alzheimer’s disease (AD) due to its multifactorial origin. Drugs that inhibit acetylcholinesterase (AChE), such as rivastigmine, are promising symptomatic treatments for AD. Emerging evidence suggests that insulin ther
Externí odkaz:
https://doaj.org/article/92921d97535b4d4ea6eb9d82c6c12859
Autor:
Schiöth, Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B.
Publikováno v:
Cells; Volume 11; Issue 22; Pages: 3528
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general
Autor:
Schiöth, Michael J. Williams, Ahmed M. Alsehli, Sarah N. Gartner, Laura E. Clemensson, Sifang Liao, Anders Eriksson, Kiriana Isgrove, Lina Thelander, Zaid Khan, Pavel M. Itskov, Thiago C. Moulin, Valerie Ambrosi, Mohamed H. Al-Sabri, Francisco Alejandro Lagunas-Rangel, Pawel K. Olszewski, Helgi B.
Publikováno v:
Cells; Volume 11; Issue 6; Pages: 970
The statin drug target, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), is strongly linked to body mass index (BMI), yet how HMGCR influences BMI is not understood. In mammals, studies of peripheral HMGCR have not clearly identified a role in BMI m