Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mohamed E M Saeed"'
Autor:
Onat Kadioglu, Mohamed E M Saeed, Markus Munder, Andreas Spuller, Henry Johannes Greten, Thomas Efferth
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 131, Iss , Pp 110718- (2020)
ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is unknown. Furthermore, the significance of their expression for pr
Externí odkaz:
https://doaj.org/article/eb35e82d742a4a19808300b31c269eaf
Autor:
Mohamed E. M. Saeed, Rümeysa Yücer, Mona Dawood, Mohamed-Elamir F. Hegazy, Assia Drif, Edna Ooko, Onat Kadioglu, Ean-Jeong Seo, Fadhil S. Kamounah, Salam J. Titinchi, Beatrice Bachmeier, Thomas Efferth
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3966 (2022)
The improvement of cancer chemotherapy remains a major challenge, and thus new drugs are urgently required to develop new treatment regimes. Curcumin, a polyphenolic antioxidant derived from the rhizome of turmeric (Curcuma longa L.), has undergone e
Externí odkaz:
https://doaj.org/article/66f69f61e67b475180bbaa830d1dd633
Autor:
Joelle C. Boulos, Mohamed E. M. Saeed, Manik Chatterjee, Yagmur Bülbül, Francesco Crudo, Doris Marko, Markus Munder, Sabine M. Klauck, Thomas Efferth
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1126 (2021)
Crizotinib was a first generation of ALK tyrosine kinase inhibitor approved for the treatment of ALK-positive non-small-cell lung carcinoma (NSCLC) patients. COMPARE and cluster analyses of transcriptomic data of the NCI cell line panel indicated tha
Externí odkaz:
https://doaj.org/article/0287c6085c9e4590b630f9d66419fce4
Publikováno v:
Cancer Genomics Proteomics
Background/Aim: Artemisinin and its derivatives are not only approved antimalarial drugs but also exert strong anticancer activity. Based on the clinical activity of artesunate (ART) that has been previously reported in cervix carcinoma, we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49565fd6a4795685f87354022cb9a11f
https://europepmc.org/articles/PMC9620444/
https://europepmc.org/articles/PMC9620444/
Autor:
Xiaohua Lu, Mohamed E. M. Saeed, Mohamed-Elamir F. Hegazy, Christopher J. Kampf, Thomas Efferth
Publikováno v:
Biomolecules, Vol 10, Iss 7, p 1000 (2020)
The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined. In the present study, we evaluated antitumor ef
Externí odkaz:
https://doaj.org/article/722e8a3b97e44592ab3fd20e8a425986
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lin
Externí odkaz:
https://doaj.org/article/2e63aae3d82b4776903432f59075cc1c
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
For decades, natural products represented a significant source of diverse and unique bioactive lead compounds in drug discovery field. In Clinical oncology, complete tumors remission is hampered by the development of drug-resistance. Therefore, devel
Externí odkaz:
https://doaj.org/article/98153297744c480c8b26e1e2bf407cef
Autor:
MOHAMED E. M. SAEED, JOELLE C. BOULOS, SABRINA B. MÜCKLICH, ELLEN LEICH, MANIK CHATTERJEE, SABINE M. KLAUCK, THOMAS EFFERTH
Publikováno v:
Cancer Genomics Proteomics
Background/Aim: Multiple myeloma (MM) is characterized by accumulation of a malignant clone of plasma cells in the bone marrow. Curative treatments are not yet available. Therefore, we undertook a drug repurposing approach to identify possible candid
Autor:
Mohamed E. M. Saeed, Rümeysa Yücer, Mona Dawood, Mohamed-Elamir F. Hegazy, Assia Drif, Edna Ooko, Onat Kadioglu, Ean-Jeong Seo, Fadhil S. Kamounah, Salam J. Titinchi, Beatrice Bachmeier, Thomas Efferth
Publikováno v:
Saeed, M E M, Yücer, R, Dawood, M, Hegazy, M E F, Drif, A, Ooko, E, Kadioglu, O, Seo, E J, Kamounah, F S, Titinchi, S J, Bachmeier, B & Efferth, T 2022, ' In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors ', International Journal of Molecular Sciences, vol. 23, no. 7, 3966 . https://doi.org/10.3390/ijms23073966
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3966
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3966
The improvement of cancer chemotherapy remains a major challenge, and thus new drugs are urgently required to develop new treatment regimes. Curcumin, a polyphenolic antioxidant derived from the rhizome of turmeric (Curcuma longa L.), has undergone e
Autor:
Mohamed E M, Saeed, Jingming, Cao, Babikir, Fadul, Onat, Kadioglu, Hassan E, Khalid, Zahir, Yassin, Siddig M, Mustafa, Elfatih, Saeed, Thomas, Efferth
Publikováno v:
Anticancer research. 36(1)
While cancer epidemiology is well-investigated in developed countries, the cancer burden in Africa is less well documented. We provide cancer statistics of 33,201 patients from all Sudan diagnosed at the Radiation and Isotope Centre in Khartoum (RICK