Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Mohamed E H, ElSayed"'
Autor:
Huyen, Tran, Phenil J, Patel, Aktham, Aburub, Andrea, Sperry, Selina, Estwick, Mohamed E H, ElSayed, Amita Datta, -Mannan
Publikováno v:
Pharmaceutical Research. 39:2555-2567
Oral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides. We report a systematic approach to identify formulation compositions combining a permeation enhancer and a pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8faa1d5e6ef9a1dbe1752e282c72140
https://doi.org/10.1007/s11095-022-03372-1
https://doi.org/10.1007/s11095-022-03372-1
Autor:
Huyen, Tran, Mohamed E H, ElSayed
Publikováno v:
Expert Opinion on Drug Delivery. 19:163-178
Numerous formulation technologies have been developed to overcome challenges of oral peptide delivery. Understanding the advantages and limitations of each technology is important for the development of new delivery systems to enable oral delivery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6066f03f61373abfedaf26d9fb117c79
https://doi.org/10.1080/17425247.2022.2051476
https://doi.org/10.1080/17425247.2022.2051476
Publikováno v:
Expert Opinion on Drug Discovery. 16:1467-1482
Introduction: To discover and develop a peptide, protein, or antibody into a drug requires overcoming multiple challenges to obtain desired properties. Proteolytic stability is one of the challenge...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c635f90f1492fc3bd27b46befaff4f
https://doi.org/10.1080/17460441.2021.1942837
https://doi.org/10.1080/17460441.2021.1942837
Autor:
Sibu P Kuruvilla, Gopinath Tiruchinapally, A Colleen Crouch, Mohamed E H ElSayed, Joan M Greve
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181944 (2017)
Hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer-related deaths every year globally. The most common form of treatment, hepatic arterial infusion (HAI), involves the direct injection of doxorubicin (DOX) into the hepatic artery. It i
Externí odkaz:
https://doaj.org/article/ffef91063b904835b2b1bf8ac381c33f
Publikováno v:
Journal of Functional Biomaterials, Vol 5, Iss 3, Pp 167-182 (2014)
Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense a
Externí odkaz:
https://doaj.org/article/22f5e684cf8b4983b703ecffb0669652
Visualizing the attack of RNase enzymes on dendriplexes and naked RNA using atomic force microscopy.
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61710 (2013)
Cationic polymers such as poly(amidoamine), PAMAM, dendrimers have been used to electrostatically complex siRNA molecules forming dendriplexes for enhancing the cytoplasmic delivery of the encapsulated cargo. However, excess PAMAM dendrimers is typic
Externí odkaz:
https://doaj.org/article/f75f9b4a7cc54081839dfcee6b733a41
Publikováno v:
International Journal of Pharmaceutics. 545:27-36
The display of N-acetylgalactosamine (NAcGal) ligands has shown great potential in improving the targeting of various therapeutic molecules to hepatocellular carcinoma (HCC), a severe disease whose clinical treatment is severely hindered by limitatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1dc0acf3cef8eb67a7ed6e730bdeed
https://doi.org/10.1016/j.ijpharm.2018.04.028
https://doi.org/10.1016/j.ijpharm.2018.04.028
Publikováno v:
Pharmaceutical Research. 34:2197-2210
This report describes the effect of rhamnolipids (RLs) on the tight junctions (TJ) of the intestinal epithelium using the rat in-situ closed loop model.We investigated the transport of 5 (6)-carboxyfluorescein (CF) and fluorescein isothiocyanate-labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e657ef6adfaab9d125ba5688e2811e0c
https://doi.org/10.1007/s11095-017-2227-y
https://doi.org/10.1007/s11095-017-2227-y
Publikováno v:
Pharmaceutical research. 36(6)
To develop a planar, asymmetric, micro-scale oral drug delivery vehicle by i) fabricating microdevice bodies with enteric materials, ii) efficiently and stably loading sensitive drug molecules, and iii) capping microdevices for controlled drug releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649924e4a02ba9835bfa11ad50d8808a
https://pubmed.ncbi.nlm.nih.gov/31004235
https://pubmed.ncbi.nlm.nih.gov/31004235
Autor:
Mohamed E. H. ElSayed, Gopinath Tiruchinapally, Yasemin Yuksel Durmaz, Ibrahim Youssef, Omer Aydin
Publikováno v:
Molecular Pharmaceutics. 13:1413-1429
WOS: 000373550600023 PubMed ID: 26977718 We report the synthesis of an amphiphilic triblock copolymer composed of a hydrophilic polyethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a hydrophobic poly(methyl methacrylate) (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8646cca806cf4e1855ddd527f14deea7
https://doi.org/10.1021/acs.molpharmaceut.6b00147
https://doi.org/10.1021/acs.molpharmaceut.6b00147