Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Mohamed Bentires‐Alj"'
Autor:
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that
Externí odkaz:
https://doaj.org/article/fdf4b11832574e5fbfe57578d57e0309
Autor:
Gaetana Restivo, Aizhan Tastanova, Zsolt Balázs, Federica Panebianco, Maren Diepenbruck, Caner Ercan, Bodgan-T. Preca, Jürg Hafner, Walter P. Weber, Christian Kurzeder, Marcus Vetter, Simone Münst Soysal, Christian Beisel, Mohamed Bentires-Alj, Salvatore Piscuoglio, Michael Krauthammer, Mitchell P. Levesque
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fresh vs. slow-frozen tissues from various malignancies are compared for the establishment of 2D, 3D and ex vivo cultures, as well as for scRNAseq analysis, and found to be comparable and suitable for cancer research.
Externí odkaz:
https://doaj.org/article/87d96e9a64c244768ec47752d441b0e3
Autor:
Katarzyna Bogucka-Janczi, Gregory Harms, Marie-May Coissieux, Mohamed Bentires-Alj, Bernd Thiede, Krishnaraj Rajalingam
Publikováno v:
eLife, Vol 12 (2023)
The actin cytoskeleton is tightly controlled by RhoGTPases, actin binding-proteins and nucleation-promoting factors to perform fundamental cellular functions. We have previously shown that ERK3, an atypical MAPK, controls IL-8 production and chemotax
Externí odkaz:
https://doaj.org/article/9c8f43e26ff449959b85e36a4d4badc1
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 6, Pp n/a-n/a (2022)
Abstract Breast cancer is the most frequent cancer among women, and metastases in distant organs are the leading cause of the cancer‐related deaths. While survival of early‐stage breast cancer patients has increased dramatically, the 5‐year sur
Externí odkaz:
https://doaj.org/article/9a71ac6f12ae43ba8630c0c4a704f717
Autor:
Frank Michael Lehmann, Nicole von Burg, Robert Ivanek, Claudia Teufel, Edit Horvath, Annick Peter, Gleb Turchinovich, Daniel Staehli, Tobias Eichlisberger, Mercedes Gomez de Agüero, Mairene Coto-Llerena, Michaela Prchal-Murphy, Veronika Sexl, Mohamed Bentires-Alj, Christoph Mueller, Daniela Finke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the a
Externí odkaz:
https://doaj.org/article/214732bb64544cc99449dba97da1e82b
Autor:
Federica Zilli, Pedro Marques Ramos, Priska Auf der Maur, Charly Jehanno, Atul Sethi, Marie‐May Coissieux, Tobias Eichlisberger, Loïc Sauteur, Adelin Rouchon, Laura Bonapace, Joana Pinto Couto, Roland Rad, Michael Rugaard Jensen, Andrea Banfi, Michael B Stadler, Mohamed Bentires‐Alj
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible pigg
Externí odkaz:
https://doaj.org/article/42ad8c50455f42c9bfe8d2e92e8ddc15
Autor:
Kimberly Roche, F Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B S Chan, Mohamed Bentires-Alj, Brian W Booth
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179265 (2017)
Introducing tumor-derived cells into normal mammary stem cell niches at a sufficiently high ratio of normal to tumorous cells causes those tumor cells to undergo a change to normal mammary phenotype and yield normal mammary progeny. This phenomenon h
Externí odkaz:
https://doaj.org/article/da062a5f92d94f1086f2f26275b37f2b
Autor:
Irmgard Hofmann, Andreas Weiss, Gaelle Elain, Maria Schwaederle, Dario Sterker, Vincent Romanet, Tobias Schmelzle, Albert Lai, Saskia M Brachmann, Mohamed Bentires-Alj, Thomas M Roberts, William R Sellers, Francesco Hofmann, Sauveur-Michel Maira
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44146 (2012)
Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no therapies exist targeting this oncogene. K-RAS signals via downstream effector pathways such as the MAPK and the PI3K signaling pathways, and much effort has
Externí odkaz:
https://doaj.org/article/42b844c37e6f4ea7a9239610c2270b0d
Autor:
Milica Vulin, Charly Jehanno, Atul Sethi, Ana Luísa Correia, Milan M. S. Obradović, Joana Pinto Couto, Marie-May Coissieux, Maren Diepenbruck, Bogdan-Tiberius Preca, Katrin Volkmann, Priska Auf der Maur, Alexander Schmidt, Simone Münst, Loïc Sauteur, Michal Kloc, Marta Palafox, Adrian Britschgi, Vincent Unterreiner, Olaf Galuba, Isabelle Claerr, Sandra Lopez-Romero, Giorgio G. Galli, Daniel Baeschlin, Ryoko Okamoto, Savas D. Soysal, Robert Mechera, Walter P. Weber, Thomas Radimerski, Mohamed Bentires-Alj
Publikováno v:
Oncogene. 41:4459-4473
Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast cancer, the subtype triple-negative lacks expression of major differentiation markers, e.g., estrogen receptor α (ERα), and its high cellular plasticity results