Výsledky vyhledávání - "Mohamed Benchekroun"

Akademický článek

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy

Autor: Emelina R. Rodríguez-Ruiz, Raquel Herrero-Labrador, Ana P. Fernández-Fernández, Julia Serrano-Masa, José A. Martínez-Montero, Daniel González-Nieto, Mayuri Hana-Vaish, Mohamed Benchekroun, Lhassane Ismaili, José Marco-Contelles, Ricardo Martínez-Murillo

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 15, p 12254 (2023)

Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer’s disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine–fe

Externí odkaz: https://doaj.org/article/dbe06503d32d4410b60bea940048ddc2

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Akademický článek

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

Autor: Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili

Publikováno v: Molecules, Vol 21, Iss 5, p 634 (2016)

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe

Externí odkaz: https://doaj.org/article/275dbed00fe84937878fb5586f6d45ed

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Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations

Autor: Samuele Maramai, Mohamed Benchekroun, Moustafa T. Gabr, Samir Yahiaoui

Publikováno v: BioMed Research International
BioMed Research International, Hindawi Publishing Corporation, 2020, 2020, pp.1-27. ⟨10.1155/2020/5120230⟩
BioMed Research International, Vol 2020 (2020)

Neurodegenerative diseases represent nowadays one of the major health problems. Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not entirely clear what triggers this phenomenon and what allows its progressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7c8fde059f67b733890cbcdda7ccff
https://doi.org/10.1155/2020/5120230

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Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D)

Autor: Mohamed Benchekroun, Saoussen Oueslati, Sandrine Ventre, Kamsana Vijayakumar, Eddy Elisée, Laetitia A. Nguyen, Edithe Selwa, Robert H. Dodd, Linda Tlili, Alain Pruvost, Pascal Retailleau, Thierry Naas, Agustin Zavala, Bogdan I. Iorga, Agathe C. A. D'Hollander, Eugénie Romero, Cynthia Exilie, Kevin Cariou, Corinne Minard

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2021, 219, ⟨10.1016/j.ejmech.2021.113418⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, 219, ⟨10.1016/j.ejmech.2021.113418⟩

International audience; The occurrence of resistances in Gram negative bacteria is steadily increasing to reach extremely worrying levels and one of the main causes of resistance is the massive spread of very efficient β-lactamases which render most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa7c8fe58be433b91cd9885050e8239
https://hal.science/hal-03227989

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Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases of classes A, B and D

Autor: Linda Tlili, Thierry Naas, Eddy Elisée, Robert H. Dodd, Mohamed Benchekroun, Agustin Zavala, Eugénie Romero, Alain Pruvost, Corinne Minard, Agathe C.A. D'Hollander, Kevin Cariou, Saoussen Oueslati, Bogdan I. Iorga, Cynthia Exilie, Sandrine Ventre, Kamsana Vijayakumar, Edithe Selwa, Pascal Retailleau, Laetitia Nguyen

The increasingly worrisome situation of antimicrobial resistances has pushed synthetic chemists to design original molecules that can fight these resistances. To do so, inhibiting β-lactamases, one of the main modes of resistance to β-lactam antibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6429d706c57db24e49ca06471b6ee68d
https://hal.archives-ouvertes.fr/hal-02998861/document

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Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1

Autor: Sandrine Ruchaud, Claire Delehouzé, Mohamed Souab, Agathe Vagneux, Ali Al-Mourabit, Stéphane Bach, Ludmila Ermolenko, Blandine Baratte, Hristo Nedev, Minh Tran, Béatrice Josselin, Mohamed Benchekroun, Bogdan I. Iorga

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 201, pp.112337. ⟨10.1016/j.ejmech.2020.112337⟩

International audience; With the aim to develop new chemical tools based on simplified natural metabolites to help deciphering the molecular mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78fa448f62c4ecf41962b517035f355
https://hal.archives-ouvertes.fr/hal-03004425/document

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Subtype selective y-Aminobutyric acid type A receptor (GABAAR) modulators acting at the benzodiazepine binding site: An update

Autor: John R. Atack, Samuele Maramai, Mohamed Benchekroun, Simon E. Ward

γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter within the central nervous system (CNS) with fast, transsynaptic, and modulatory extrasynaptic effects being mediated by the ionotropic GABA type A receptors (GABAARs). These recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f2170dc7dd9ed0837d69901321320a

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Multitarget-directed ligands for neurodegenerative diseases: real opportunity or blurry mirage?

Autor: Mohamed Benchekroun, Samuele Maramai

Publikováno v: Future Medicinal Chemistry. 11:261-263

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f132dd9bbb0df8683dc83edd0f6f91
https://doi.org/10.4155/fmc-2018-0249

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New contributions to the drug profile of TNFα inhibitor SPD304: Affinity, selectivity and ADMET considerations

Autor: Ghada Attia, Patrick Gizzi, Mohamed Benchekroun, Maité Sylla-Iyarreta Veitía, Najla Fourati, Hadley Mouhsine, Jean-François Zagury, Aïda Mascret, Chouki Zerrouki, Damien Cabrera, Marc Port

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 2021, 907, pp.174285. ⟨10.1016/j.ejphar.2021.174285⟩

Tumor necrosis factor alpha (TNFα) is a relevant clinical target for the treatment of chronic inflammatory diseases. Currently, only few small molecules are known as direct inhibitors of TNFα. To date, none of these molecules has shown both an effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e288c2ed2947a0c448f1026eb68ea68
https://doi.org/10.1016/j.ejphar.2021.174285

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