mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells

Autor: David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing

Publikováno v: Antioxidants, Vol 10, Iss 12, p 1944 (2021)

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation, a

Externí odkaz: https://doaj.org/article/a96bde4bc24e4a1698fe33f4427a320d

Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus.

Autor: Mohamed Ali Jarboui, Carlo Bidoia, Elena Woods, Barbara Roe, Kieran Wynne, Giuliano Elia, William W Hall, Virginie W Gautier

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48702 (2012)

The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and structured membrane-less sub-nuclear compartment, is the site of rR

Externí odkaz: https://doaj.org/article/e7ce1f91007a4f2297e7ae7904355e0f

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Autor: Pavel Klener, Klaus Schulze-Osthoff, Karsten Boldt, Philipp Berning, Martina Konantz, Michael Grau, Georg Lenz, Caroline Schönfeld, Wendan Xu, Philip Bucher, Petra Vockova, Mohamed Ali Jarboui, Anja Schmitt, Andreas Rosenwald, German Ott, Melanie Grimm, Claudia Lengerke, Marc Brändle, Heike Horn, Stephan Hailfinger, Myroslav Zapukhlyak

Publikováno v: Blood. 138:871-884

Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) still poses a substantial therapeutic challenge. DLBCL can be classified into at least 2 major subtypes (germinal center B cell [GCB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71790a932be7618d1a2c827477d0e894
https://doi.org/10.1182/blood.2020009404

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Autor: Max Kotlyar, Priyanka Pillai, Theodosia Charitou, David Matallanas, Victoria Wong, Cinzia Raso, Luis F. Iglesias-Martinez, Colm J. Ryan, Steven Shave, Carlos Herrera-Montavez, Nicola Horn, Ruth Pilkington, Christina Kiel, Layal Dernayka, Miriam A. Lynn, Igor Jurisica, Manuel Bernal-Llinares, Lisa Imrie, Nora Rauch, Franziska Klose, Owen J. Sansom, David J. Lynn, Sriganesh Srihari, Marius Ueffing, Karsten Boldt, Luis Serrano, James Breen, Aleksandar Krstic, Erik Fasterius, Igor Stagljar, Kenneth Bryan, Mohamed Ali Jarboui, Thierry LeBihan, Boris N. Kholodenko, Oleksii S. Rukhlenko, Jasna Curak, Susan Kennedy, Manfred Auer, Cristina Al-Khalili Szigyarto, Walter Kolch, Patrizia Cammareri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Kennedy, S A, Jarboui, M, Srihari, S, Raso, C, Bryan, K, Dernayka, L, Charitou, T, Bernal-llinares, M, Herrera-montavez, C, Krstic, A, Matallanas, D, Kotlyar, M, Jurisica, I, Curak, J, Wong, V, Stagljar, I, Lebihan, T, Imrie, L, Pillai, P, Lynn, M A, Fasterius, E, Al-khalili Szigyarto, C, Breen, J, Kiel, C, Serrano, L, Rauch, N, Rukhlenko, O, Kholodenko, B N, Iglesias-martinez, L F, Ryan, C J, Pilkington, R, Cammareri, P, Sansom, O, Shave, S, Auer, M, Horn, N, Klose, F, Ueffing, M, Boldt, K, Lynn, D J & Kolch, W 2020, ' Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14224-9
nature.com

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc319b683485723bed6ff60ef6bb1dac
http://link.springer.com/article/10.1038/s41467-019-14224-9

mTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells

Autor: Angela Armento, Michela Deleidi, Ellen Kilger, David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Simon J. Clark, Marius Ueffing

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including ageing, genetics and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a4de9b2ce763f1c51315e7acef48dc0
https://doi.org/10.1101/2021.10.29.466270