Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Mohamed Abdel-Mohsen"'
Autor:
Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel-Mohsen, Joseph Mudd, Prasun K. Datta, Nicholas J. Maness, Gabrielle Lehmicke, Nadia Golden, Linh Hellmers, Carol Coyne, Kristyn Moore Green, Cecily Midkiff, Kelsey Williams, Rafael Tiburcio, Marissa Fahlberg, Kyndal Boykin, Carys Kenway, Kasi Russell-Lodrigue, Angela Birnbaum, Rudolf Bohm, Robert Blair, Jason P. Dufour, Tracy Fischer, Ahmad A. Saied, Jay Rappaport
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of anima
Externí odkaz:
https://doaj.org/article/f08910814723411b8c7b83f16cf5d078
Autor:
Leila B. Giron, Qin Liu, Opeyemi S. Adeniji, Xiangfan Yin, Toshitha Kannan, Jianyi Ding, David Y. Lu, Susan Langan, Jinbing Zhang, Joao L. L. C. Azevedo, Shuk Hang Li, Sergei Shalygin, Parastoo Azadi, David B. Hanna, Igho Ofotokun, Jason Lazar, Margaret A. Fischl, Sabina Haberlen, Bernard Macatangay, Adaora A. Adimora, Beth D. Jamieson, Charles Rinaldo, Daniel Merenstein, Nadia R. Roan, Olaf Kutsch, Stephen Gange, Steven M. Wolinsky, Mallory D. Witt, Wendy S. Post, Andrew Kossenkov, Alan L. Landay, Ian Frank, Phyllis C. Tien, Robert Gross, Todd T. Brown, Mohamed Abdel-Mohsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this
Externí odkaz:
https://doaj.org/article/834ccc7d78f64593bd700f4fd920f417
Autor:
Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J. Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T. Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it’s unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored. Here, we show tha
Externí odkaz:
https://doaj.org/article/f6c6df012ec140a7a4fd2deb6a11201f
Autor:
Mohamed Abdel-Mohsen, Steven Deeks, Leila Giron, Kai Ying Hong, Aaron Goldman, Liao Zhang, Susie S. Y. Huang, Donovan Verrill, Susan Guo, Lisa Selzer, Christiaan R. de Vries, Elena Vendrame, Devi SenGupta, Jeffrey J. Wallin, Yanhui Cai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAntiretroviral therapy (ART) for HIV-1 treatment has improved lifespan but requires lifelong adherence for people living with HIV (PLWH), highlighting the need for a cure. Evaluation of potential cure strategies requires analytic treatment
Externí odkaz:
https://doaj.org/article/095bab4f17fa480d8c63f5de87ce6252
Autor:
Shalini Singh, Leila B. Giron, Maliha W. Shaikh, Shivanjali Shankaran, Phillip A. Engen, Zlata R. Bogin, Simona A. Bambi, Aaron R. Goldman, Joao L. L. C. Azevedo, Lorena Orgaz, Nuria de Pedro, Patricia González, Martin Giera, Aswin Verhoeven, Elena Sánchez-López, Ivona Pandrea, Toshitha Kannan, Ceylan E. Tanes, Kyle Bittinger, Alan L. Landay, Michael J. Corley, Ali Keshavarzian, Mohamed Abdel-Mohsen
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-23 (2024)
Abstract Background People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and transl
Externí odkaz:
https://doaj.org/article/03326450ced04999be69828f4f9541f9
Autor:
Daniel B. Reeves, Charline Bacchus-Souffan, Mark Fitch, Mohamed Abdel-Mohsen, Rebecca Hoh, Haelee Ahn, Mars Stone, Frederick Hecht, Jeffrey Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Joshua T. Schiffer, Peter W. Hunt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and
Externí odkaz:
https://doaj.org/article/ffc6674a545d4c69bd5e2cf799eb8bae
Autor:
Amin Izadpanah, Joseph C. Mudd, Joe G. N. Garcia, Sudesh Srivastav, Mohamed Abdel-Mohsen, Clovis Palmer, Aaron R. Goldman, Jay K. Kolls, Xuebin Qin, Jay Rappaport
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 results initially in pulmonary infection and inflammation. Symptoms can persist beyond the period of acute infection, and patients with Post-Acute Sequelae of COVID (PASC) often exhibit a variety of symptoms weeks or month
Externí odkaz:
https://doaj.org/article/e6397cf7b85b4dc0bf1a3ddf781f1494
Autor:
Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, Robert A. Balk, James N. Moy, Leila B. Giron, Russell P. Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B. Weiner, Mohamed Abdel-Mohsen
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the immunological profiles of natural killer (NK) cells. However, whether NK antiviral functions are impaired during severe coronavirus disease 2019 (COVID-19) and
Externí odkaz:
https://doaj.org/article/9b30c013c37148c591071bf5b0975101
Autor:
Erika G. Marques de Menezes, Jocelyn S. Liu, Scott A. Bowler, Leila B. Giron, Michelle L. D’Antoni, Cecilia M. Shikuma, Mohamed Abdel-Mohsen, Lishomwa C. Ndhlovu, Philip J. Norris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundNeurocognitive impairment remains prevalent in people with HIV (PWH) despite long term virological suppression by antiretroviral therapy (ART) regimens. Systemic and neuro-inflammatory processes are suggested to contribute to the complex pa
Externí odkaz:
https://doaj.org/article/536e2f5815834ab88349d615c6ec14ca
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104354- (2022)
Summary: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialo
Externí odkaz:
https://doaj.org/article/0925d9ecf0974676ba6101e034387f5e