Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mohamed A. Genead"'
Autor:
Anitha Krishnan, David G. Callanan, Victor G. Sendra, Amit Lad, Sunny Christian, Ravinder Earla, Ali Khanehzar, Andrew J. Tolentino, Valory Anne Sarmiento Vailoces, Michelle K. Greene, Christopher J. Scott, Derek Y. Kunimoto, Tarek S. Hassan, Mohamed A. Genead, Michael J. Tolentino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 481 (2024)
An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has been developed to treat geographic atrophy/age-related macular degeneration and other conditions caused by macrophage and complement over-activation. While PolySia
Externí odkaz:
https://doaj.org/article/a214705fd1b04dce98986778fed379cd
Autor:
Sheri L. Peterson, Anitha Krishnan, Diyan Patel, Ali Khanehzar, Amit Lad, Jutamas Shaughnessy, Sanjay Ram, David Callanan, Derek Kunimoto, Mohamed A. Genead, Michael J. Tolentino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 517 (2024)
The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, w
Externí odkaz:
https://doaj.org/article/43f2d905e6624be6a4ed977d1f6bf689
Autor:
Michael J. Tolentino, Andrew J. Tolentino, Elizabeth M. Tolentino, Anitha Krishnan, Mohamed A. Genead
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1735 (2023)
Age-related macular degeneration (AMD), a leading cause of visual loss and dysfunction worldwide, is a disease initiated by genetic polymorphisms that impair the negative regulation of complement. Proteomic investigation points to altered glycosylati
Externí odkaz:
https://doaj.org/article/89fc0c1afd1c41e0a987244cda953857
Publikováno v:
Retina. 34:989-995
PURPOSE To evaluate dark-adapted retinal sensitivity in patients with Stargardt disease (STGD1) using a modified MP-1 microperimeter and to compare the sensitivity loss with structural changes observed using spectral domain optical coherence tomograp
Publikováno v:
Survey of Ophthalmology. 58:560-584
Cystic macular lesions frequently contribute to impaired visual acuity in hereditary retinal dystrophies. Their pathogenesis varies and is not entirely understood. Carbonic anhydrase inhibitors have proven to be potentially efficacious, although not
Publikováno v:
Eye. 27:1044-1052
The purpose of this study was to measure macular sensitivity using microperimetry in patients on Plaquenil therapy without evidence of retinopathy as assessed by recommended screening standards. Sixteen patients from a clinical practice treated with
Publikováno v:
Ophthalmic Genetics. 35:47-50
To determine the prevalence of macular cysts in patients with clinical cone-rod dystrophy (CORD) using spectral-domain optical coherence tomography (SD-OCT). If macular cysts could be demonstrated in such patients, they might benefit from treatment w
Publikováno v:
Retina. 32:358-363
PURPOSE To measure the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography in patients with retinitis pigmentosa. METHODS Fifty eyes of 30 patients with retinitis pigmentosa underwent a complete
Publikováno v:
Retina. 31:949-958
Purpose To correlate the degree of functional loss with structural changes in patients with Stargardt disease. Methods Eighteen eyes of 10 patients with Stargardt disease were studied. Scanning laser ophthalmoscope infrared images were compared with
Publikováno v:
Ophthalmic Genetics. 32:101-106
To evaluate the presence of peripapillary retinal nerve fiber layer (RNFL) defects in patients with choroideremia by using spectral-domain optical coherence tomography (SD-OCT).Twenty-nine eyes of 16 patients with choroideremia underwent peripapillar