Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mohamed A. El-Zahabi"'
Autor:
Eslam B. Elkaeed, Mohammed S. Taghour, Hazem A. Mahdy, Wagdy M. Eldehna, Nehal M. El-Deeb, Ahmed M. Kenawy, Bshra A. Alsfouk, Mohammed A. Dahab, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed A. El-Zahabi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2191-2205 (2022)
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed compar
Externí odkaz:
https://doaj.org/article/23225f8a56d246569bcac354c3c67f09
Autor:
Reda R. Mabrouk, Abdallah E. Abdallah, Hazem A. Mahdy, Samar A. El-Kalyoubi, Omar Jamal Kamal, Tamer M. Abdelghany, Mohamed F. Zayed, Heba K. Alshaeri, Moudi M. Alasmari, Mohamed Ayman El-Zahabi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12416 (2023)
Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular carcinoma (HepG-2), prostate cancer (PC3), and breast cancer (MCF-7)
Externí odkaz:
https://doaj.org/article/1714cc9cf1734f089424eb8d09c35ac6
Autor:
Mohamed Ayman El-Zahabi, Faida H. Bamanie, Salah Ghareeb, Heba K. Alshaeri, Moudi M. Alasmari, Mohamed Moustafa, Zohair Al-Marzooki, Mohamed F. Zayed
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9605 (2022)
New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a reference drug. Compounds VI-6-a, V, IV-4, VI-4-c, IV-6, VI-2-a, IV-1, and IV-2
Externí odkaz:
https://doaj.org/article/3fa8539b5a6d493a9bea420409ad1559
Autor:
Anas Ramadan Kotb, Abdallah E. Abdallah, Hazem Elkady, Ibrahim H. Eissa, Mohammed S. Taghour, Dina Abed Bakhotmah, Tamer M. Abdelghany, Mohamed Ayman El-Zahabi
Publikováno v:
RSC Advances. 13:10488-10502
Novel thalidomide analogs as anticancer immunomodulatory agents.
Autor:
Abdallah E. Abdallah, Reda R. Mabrouk, Maged Mohammed Saleh Al Ward, Sally I. Eissa, Eslam B. Elkaeed, Ahmed B. M. Mehany, Mariam A. Abo-Saif, Ola A. El-Feky, Mohamed S. Alesawy, Mohamed Ayman El-Zahabi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 573-591 (2022)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared
Autor:
Mohamed Ayman El-Zahabi, Hazem Elkady, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Khaled. El-Adl
In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized compounds were evaluated for their cytotoxic activities against HepG-2, HCT-116, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db46a196ec3fac0d375af3a1051e6213
Autor:
Anas Ramadan Kotb, Dina A. Bakhotmah, Abdallah E. Abdallah, Hazem Elkady, Mohammed S. Taghour, Ibrahim. H. Eissa, Mohamed Ayman El-Zahabi
Publikováno v:
RSC advances. 12(52)
Cancer is still a dangerous disease with a high mortality rate all over the world. In our attempt to develop potential anticancer candidates, new quinazoline and phthalazine based compounds were designed and synthesized. The new derivatives were buil
Autor:
Abdallah E. Abdallah, Ibrahim H. Eissa, Ahmed B.M. Mehany, Helmy Sakr, Ahmed Atwa, Khaled El-Adl, Mohamed Ayman El-Zahabi
Publikováno v:
Journal of Molecular Structure. 1281:135164
Autor:
Eslam B. Elkaeed, Reda G. Yousef, Mohamed M. Khalifa, Albaraa Ibrahim, Ahmed B. M. Mehany, Ibraheem M. M. Gobaara, Bshra A. Alsfouk, Wagdy M. Eldehna, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed Ayman El-Zahabi
Publikováno v:
Molecules; Volume 27; Issue 19; Pages: 6203
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric essential features to bind correctly with the VEGFR-2 active pocket. All members were evaluated f
Autor:
Ahmed A, Nasser, Ibrahim H, Eissa, Mohamed R, Oun, Mohamed A, El-Zahabi, Mohammed S, Taghour, Amany, Belal, Abdulrahman M, Saleh, Ahmed B M, Mehany, Hendrik, Luesch, Ahmad E, Mostafa, Wael M, Afifi, James R, Rocca, Hazem A, Mahdy
Publikováno v:
Organicbiomolecular chemistry. 18(38)
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds were synthesized and evaluated for their in vitro cytotoxic activities