Výsledky vyhledávání - "Mohamed A El-Nabarawi"

Akademický článek

Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling.

Autor: Shahinaze A Fouad, Fady A Malaak, Mohamed A El-Nabarawi, Khalid Abu Zeid, Amira M Ghoneim

Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245482 (2021)

Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited bioavailability. Solid dispersion systems (SD) of DCN were prepared by solvent evaporation, using hydrophilic polymers. In-vitro dissolution studies were performed a

Externí odkaz: https://doaj.org/article/637334db79e24c30b51a5ca0361fd62e

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Akademický článek

Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation.

Autor: Shahinaze A Fouad, Fady A Malaak, Mohamed A El-Nabarawi, Khalid Abu Zeid

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244646 (2020)

Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main sid

Externí odkaz: https://doaj.org/article/84d05b4a657c40e098b3edbd5f4ec97d

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Akademický článek

Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

Autor: Mohamed A El-Nabarawi, Saadia A Tayel, Nadia A Soliman, Hadel A Abo Enin

Publikováno v: Journal of Pharmacy and Bioallied Sciences, Vol 5, Iss 3, Pp 191-201 (2013)

Objective: A stress induced rise in the blood pressure. Some believe that patients with hypertension are characterized by a generalized state of increased anxiety. Aim: The purpose of this study is to prepare a fixed dose bi therapy using bisoprolol

Externí odkaz: https://doaj.org/article/954e56d9c5d547c5a660cc73117ddcb4

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Akademický článek

Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation

Autor: Rehab Abdelmonem, Inas Essam Ibrahim Al-Samadi, Rasha M. El Nashar, Bhaskara R. Jasti, Mohamed A. El-Nabarawi

Publikováno v: Drug Delivery, Vol 29, Iss 1, Pp 2868-2882 (2022)

Loratadine (LORA), is a topical antihistamine utilized in the treatment of ocular symptoms of COVID-19. The study aimed to develop a Loratadine Nanostructured Lipid Carriers Ocugel (LORA-NLCs Ocugel), enhance its solubility, trans-corneal penetrabili

Externí odkaz: https://doaj.org/article/709bd12231c24be39250a6dbb6b3f58c

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Akademický článek

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OPTIMIZING LEVETIRACETAM SURFACTANT-BASED NANOVESICLES (LEV-NVS) GEL FOR TREATING EPILEPSY USING EXPERIMENTAL DESIGN

Autor: MAHMOUD H. TEAIMA, HUSSIEN MOHAMED AHMED EL-MESSIRY, HAJAR ABDULRADI SHAKER, MOHAMED A. EL-NABARAWI, DOAA A. HELAL

Publikováno v: International Journal of Applied Pharmaceutics. :194-200

Objective: To develop and estimate the intranasal delivery of Levetiracetam surfactant-based nanovesicles (Lev-Nvs) as a brain-targeted antiepileptic delivery system prepared via solvent evaporation technique. Methods: Optimized formulation F (OPT) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7d5da15f26ad57fa4f81c0471b53cc1
https://doi.org/10.22159/ijap.2023v15i2.46450

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NANO-DELIVERY SYSTEMS FOR ENHANCING ORAL BIOAVAILABILITY OF DRUGS

Autor: MENNA M. ABDELLATIF, SARA MOHAMED AHMED, MOHAMED A. EL-NABARAWI, MAHMOUD TEAIMA

Publikováno v: International Journal of Applied Pharmaceutics. :13-19

The two main issues impacting oral delivery are drug solubility and permeability. The FDA adopted the Biopharmaceutics Classification System (BCS) in 2000. The BCS categorizes drugs into four classes based on their solubility and permeability. For pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0120f4a77551836f4cfe35e4e26d66e5
https://doi.org/10.22159/ijap.2023v15i1.46758

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THE EFFECT OF CO-PROCESSED EXCIPIENTS DURING FORMULATION AND EVALUATION OF PEDIARIC LEVETIRACETAM ORODISPERSIBLE TABLETS IN RATS

Autor: MAHMOUD H. TEAIMA, HUSSIEN MOHAMED AHMED EL MESSIRY, TASNEEM DAHI OSMAN, MOHAMED A. EL-NABARAWI, DOAA A. HELAL

Publikováno v: International Journal of Applied Pharmaceutics. :318-323

Objective: The main aim of this research was to make cost-effective taste-masking oral pediatric orodispersible tablets (ODTs) of Levetiracetam as an antiepileptic drug (AED) using various co-processed excipients by direct compression method. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25088fe4d90282dcafe358443d84d665
https://doi.org/10.22159/ijap.2023v15i1.45298

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FOCUS ON NIOSOMAL–BASED DRUG DELIVERY SYSTEMS FOR NASAL ROUTE: APPLICATIONS AND CHALLENGES

Autor: SAEED A. S. AL-ZUHAIRY, HOSSAM`` S. EL-SAWY, MOHAMED A. EL-NABARAWI, MAHMOUD H. TEAIMA

Publikováno v: International Journal of Applied Pharmaceutics. :36-43

For decades, the nasal route of administration is principally used for many therapeutic applications owing to the non-invasive nature of the nasal pathway. Besides, it circumvents blood-brain-barrier (BBB) and hepatic first-pass effect. Consequently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::817cc768aa8e6207c65a64d334552922
https://doi.org/10.22159/ijap.2023v15i1.46280

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