Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Mohamed‐Ali Hakimi"'
Autor:
Arne L. ten Hoeve, Matias E. Rodriguez, Martin Säflund, Valentine Michel, Lucas Magimel, Albert Ripoll, Tianxiong Yu, Mohamed-Ali Hakimi, Jeroen P. J. Saeij, Deniz M. Ozata, Antonio Barragan
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite Toxoplasma gondii. Here, we report how a set of secreted parasite effector proteins from dense granule organelles (GRA) orchestrates dendritic cell-li
Externí odkaz:
https://doaj.org/article/d1af7be0607e46cc97c4b761845075f1
Autor:
Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011124 (2023)
The prolyl-tRNA synthetase (PRS) is a validated drug target for febrifugine and its synthetic analog halofuginone (HFG) against multiple apicomplexan parasites including Plasmodium falciparum and Toxoplasma gondii. Here, a novel ATP-mimetic centered
Externí odkaz:
https://doaj.org/article/e8c18ac0c4d34cadb55ade27bc2b2c94
Autor:
Céline Dard, Christopher Swale, Marie-Pierre Brenier-Pinchart, Dayana C. Farhat, Valeria Bellini, Marie Gladys Robert, Dominique Cannella, Hervé Pelloux, Isabelle Tardieux, Mohamed-Ali Hakimi
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
Abstract Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in met
Externí odkaz:
https://doaj.org/article/1908785e03664ac6b6619f432b747fd2
Autor:
Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek, Dominique Soldati-Favre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-26 (2020)
Abstract Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enz
Externí odkaz:
https://doaj.org/article/0004984a4e99407ead65792007c4abe9
Autor:
Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar, Abhishek Dusane, Benoît Laleu, Valeria Bellini, Mohamed-Ali Hakimi, Alexandre Bougdour, Amit Sharma
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010363 (2022)
Toxoplasmosis is caused by Toxoplasma gondii and in immunocompromised patients it may lead to seizures, encephalitis or death. The conserved enzyme prolyl-tRNA synthetase (PRS) is a validated druggable target in Toxoplasma gondii but the traditional
Externí odkaz:
https://doaj.org/article/41402e30ad6545e083b42016c9121930
Autor:
Dayana C Farhat, Matthew W Bowler, Guillaume Communie, Dominique Pontier, Lucid Belmudes, Caroline Mas, Charlotte Corrao, Yohann Couté, Alexandre Bougdour, Thierry Lagrange, Mohamed-Ali Hakimi, Christopher Swale
Publikováno v:
eLife, Vol 10 (2021)
Correct 3’end processing of mRNAs is one of the regulatory cornerstones of gene expression. In a parasite that must adapt to the regulatory requirements of its multi-host life style, there is a need to adopt additional means to partition the distin
Externí odkaz:
https://doaj.org/article/88128cb858e5426693c5709fdfe3669c
Autor:
Jacinthe Azevedo, Claire Picart, Laurent Dureau, Dominique Pontier, Sylvie Jaquinod‐Kieffer, Mohamed‐Ali Hakimi, Thierry Lagrange
Publikováno v:
FEBS Open Bio, Vol 9, Iss 5, Pp 973-985 (2019)
Repeated sequence expression and transposable element mobilization are tightly controlled by multilayer processes, which include DNA 5′‐cytosine methylation. The RNA‐directed DNA methylation (RdDM) pathway, which uses siRNAs to guide sequence
Externí odkaz:
https://doaj.org/article/033f1a6f81bc4b5384af7dbf5918f62c
Autor:
Valeria Bellini, Christopher Swale, Marie-Pierre Brenier-Pinchart, Tiffany Pezier, Sonia Georgeault, Fabrice Laurent, Mohamed-Ali Hakimi, Alexandre Bougdour
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101871- (2020)
Summary: Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclini
Externí odkaz:
https://doaj.org/article/c725b458c075442e97bae02c47af5726
Autor:
Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 385-394 (2017)
Abstract Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans. Available therapeutic agents are limited by suboptimal efficacy and freq
Externí odkaz:
https://doaj.org/article/96892dd7fa464077a75b0e590d1fd393
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
As a response to a diverse array of external stimuli, early growth response protein 1 (Egr-1) plays important roles in the transcriptional regulation of inflammation and the cellular immune response. However, a number of intracellular pathogens colon
Externí odkaz:
https://doaj.org/article/a82cb4d0b93b4ee0ad8912c8d1623f17