Early detection of liver injuries by the Serum enhanced binding test sensitive to albumin post-transcriptional modifications

Autor: Souleiman El Balkhi, Mohamad Ali Rahali, Roy Lakis, François Ludovic Sauvage, Marving Martin, Angelika Janaszkiewicz, Roland Lawson, Ruben Goncalves, Paul Carrier, Veronique Loustaud-Ratti, Anne Guyot, Pierre Marquet, Florent Di Meo, Franck Saint-Marcoux

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development. We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifica

Externí odkaz: https://doaj.org/article/3c8764e0103749939d7a5e874938b004

Effect of Sevelamer and Nicotinamide on Albumin Carbamylation in Patients with End-Stage Kidney Disease

Autor: Ziad A. Massy, François-Ludovic Sauvage, Gabriel Choukroun, Marie Essig, Souleiman El Balkhi, Aurélie Lenglet, Mohamad Ali Rahali, Sophie Liabeuf

Publikováno v: Drugs in R&D
Drugs in R&D, Springer Verlag, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩
Drugs in R&D, 2021, 21 (2), pp.231-238. ⟨10.1007/s40268-021-00350-7⟩

Background and Objective In end-stage kidney disease, high urea levels promote the carbamylation of lysine side chains on a variety of proteins, including albumin. Albumin carbamylation has been identified as a risk factor for mortality and sevelamer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dbd707c6775e23ab843dce5a4de42e
https://doi.org/10.1007/s40268-021-00350-7