Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Mohabir Ramjeesingh"'
Autor:
Adrian Constantin Tanjala, Jia Xin Jiang, Paul D. W. Eckford, Mohabir Ramjeesingh, Canhui Li, Ling Jun Huan, Gabrielle Langeveld, Claire Townsend, Daniel V. Paone, Jakob Busch-Petersen, Roman Pekhletski, LiPing Tang, Vamsee Raju, Steven M. Rowe, Christine E. Bear
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Cystic Fibrosis causing mutations in the gene CFTR, reduce the activity of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor lung function. A role for CFTR in the pathogenesis of other muco-obst
Externí odkaz:
https://doaj.org/article/2da00d71ae6d4c6493740fb315b80270
Autor:
Onofrio Laselva, Zafar Qureshi, Zhi-Wei Zeng, Evgeniy V. Petrotchenko, Mohabir Ramjeesingh, C. Michael Hamilton, Ling-Jun Huan, Christoph H. Borchers, Régis Pomès, Robert Young, Christine E. Bear
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102542- (2021)
Summary: Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis. Electron cryomicroscopy (cryo-EM) studies of detergent-solubilized CFTR
Externí odkaz:
https://doaj.org/article/8c79a33405ed438787e6e0dfeeeb1030
Autor:
Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Hong Cui, Onofrio Laselva, Jean-Philippe Julien, Christine E. Bear
Publikováno v:
Cells, Vol 8, Iss 8, p 804 (2019)
The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. Interesting
Externí odkaz:
https://doaj.org/article/1f1cefb53ced4f29a9b93238e1506a92
Autor:
Zhi-Wei Zeng, Zafar Qureshi, Robert N. Young, Christine E. Bear, Evgeniy V. Petrotchenko, Onofrio Laselva, Mohabir Ramjeesingh, Christoph H. Borchers, Ling-Jun Huan, Régis Pomès, C. Michael Hamilton
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102542-(2021)
iScience
iScience
Summary Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis. Electron cryomicroscopy (cryo-EM) studies of detergent-solubilized CFTR i
Autor:
Zeng Zw, Ling Jun Huan, Zafar Qureshi, Régis Pomès, Onofrio Laselva, Evgeniy V. Petrotchenko, Christine E. Bear, Mohabir Ramjeesingh, R. Young, Christoph H. Borchers, M. Hamilton
Publikováno v:
Journal of Cystic Fibrosis. 20:S301
Autor:
Louise C. Pyle, Steve Aller, Hal A. Lewis, Wei Wang, Eric J. Sorscher, Gergely L. Lukacs, Shane Atwell, Christine E. Bear, W. Joon Chung, Annette Ehrhardt, Kryzysztof Nowotarski, Kevin L. Kirk, Cory M. Mulvihill, Jeong S. Hong, Mohabir Ramjeesingh, Sadanandan E. Velu
Publikováno v:
Journal of Biological Chemistry. 291:1854-1865
In this study, we present data indicating a robust and specific domain interaction between the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop (CL1) and nucleotide binding domain 1 (NBD1) that allows ion transport to p
Autor:
Saumel Ahmadi, Stephanie Chin, Herman Yeger, Kai Du, Mohabir Ramjeesingh, Ling-Jun Huan, Christine E. Bear, Paul Taylor, Stan Pasyk, Michael F. Moran, Steven Molinski
Publikováno v:
PROTEOMICS. 15:447-461
The major cystic fibrosis causing mutation, F508del-CFTR (where CFTR is cystic fibrosis transmembrane conductance regulator), impairs biosynthetic maturation of the CFTR protein, limiting its expression as a phosphorylation-dependent channel on the c
Autor:
Mohabir Ramjeesingh, Patrick Kim Chiaw, Christine E. Bear, Stan Pasyk, Canhui Li, Leigh Wellhauser
Publikováno v:
Molecular Pharmacology. 75:1430-1438
The deletion of Phe-508 (DeltaPhe508) constitutes the most prevalent of a number of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that cause cystic fibrosis (CF). This mutation leads to CFTR misfolding and retention in t
Autor:
Mohabir Ramjeesingh, Christine E. Bear, Ling-Jun Huan, Francisca Ugwu, Fiona L. L. Stratford, Canhui Li
Publikováno v:
Biochemical Journal. 412:315-321
The two NBDs (nucleotide-binding domains) of ABC (ATP-binding-cassette) proteins function in a complex to mediate ATPase activity and this activity has been linked to their regulated transport activity. A similar model has been proposed for CFTR (cys
Publikováno v:
Biochemical Journal. 396:449-460
The ClC family of chloride channels and transporters includes several members in which mutations have been associated with human disease. An understanding of the structure–function relationships of these proteins is essential for defining the molec