Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Moh'd Mohanad Al-Dabet"'
Autor:
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR). While plasma levels of
Externí odkaz:
https://doaj.org/article/2ce97d19ca754507a003d6b16a5ab8c0
Autor:
Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyp
Externí odkaz:
https://doaj.org/article/e0c24968fbe44886ac4eb5d91d955ed8
Autor:
Richard Klar, Nora Klöting, Peter R. Mertens, Matthias Blüher, Sven Michel, Frank Jaschinski, Ahmed Elwakiel, Sameen Fatima, Peter P. Nawroth, Hamzah Khawaja, Saira Ambreen, Moh'd Mohanad Al-Dabet, Khurrum Shahzad, Berend Isermann, Ihsan Gadi
Publikováno v:
J. Am. Soc. Nephrol. 32, 3066-3079 (2021)
J Am Soc Nephrol
J Am Soc Nephrol
Background: Maladaptive ER stress signaling in diabetic kidney disease (DKD) is linked to increased glomerular and tubular expression of the cell death-promoting transcription factor C/EBP homologous protein (CHOP). We determined whether therapy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3315ed850e672d0e0fcc8a0a9775cf
https://doi.org/10.1681/asn.2021040431
https://doi.org/10.1681/asn.2021040431
Autor:
Wajdy Al-Awaida, Hadeel Al‐Turk, Hamzeh J Al-Ameer, Omar Al bawareed, Akram Al Deek, Muhanad Akash, Ghizal Fatima, Amer Imraish, Raida Khalil, Moh'd Mohanad Al-Dabet
Publikováno v:
International Migration. 60:219-227
To ward off the outbreak of the coronavirus disease (COVID‐19) in 2019, the Jordanian government applied quarantine to the Jordanian population in addition to Syrian refugees We evaluated the quarantine's psychological effect on people in Jordan af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4be23dc92d4505c4b4016a9d848bd7b
https://doi.org/10.1111/imig.12847
https://doi.org/10.1111/imig.12847
Autor:
Haider J Al Hassany, Moh'd Mohanad Al-Dabet, Wajdy Al-Awaida, Najah R. Hadi, Omar Al-Bawareed, Wasan Sami Hameed
Publikováno v:
Medical Archives
Background: Diabetes mellitus (DM) is the world’s most common cause of chronic kidney diseases (CKD), with approximately 1 in 4 adults with DM having CKD and 1 out of 10 to 20% of DM patients die from CKD. Objective: The current study aims to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57d1a946d6e1250099431ea09e05173
http://europepmc.org/articles/PMC8228649
http://europepmc.org/articles/PMC8228649
Autor:
Silke Zimmermann, Alireza R. Rezaie, Marcus J. Moeller, Sumra Nazir, Liliana Schaefer, Shruthi Krishnan, Shrey Kohli, Ihsan Gadi, Wei Dong, Sanchita Ghosh, Rajiv Rana, Wolfram Ruf, Dheerendra Gupta, Thati Madhusudhan, Jochen Reiser, Stoyan Stoyanov, Hongjie Wang, Jinyang Zeng-Brouwers, Charles T. Esmon, Ronald Biemann, Berend Isermann, Moh'd Mohanad Al-Dabet, Ahmed Elwakiel, Akash Mathew
Publikováno v:
J Am Soc Nephrol
Journal of the American Society of Nephrology 31(8), 1762-1780 (2020). doi:10.1681/ASN.2019111163
Journal of the American Society of Nephrology 31(8), 1762-1780 (2020). doi:10.1681/ASN.2019111163
BACKGROUND: Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease–dependent signaling modulates dNP, in part via the G protein–coupled, protease-activated receptors (PARs). Specifically, the cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ab745eca9cb5e689ba1bc527af7d47
https://doi.org/10.1681/asn.2019111163
https://doi.org/10.1681/asn.2019111163
Autor:
Amer Imraish, Wajdy Al-Awaida, Omar Al bawareed, Hamzeh J Al-Ameer, Hadeel Al‐Turk, Ghizal Fatima, Akram Al Deek, Moh'd Mohanad Al-Dabet, Raida Khalil, Muhanad Akash
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f807a2a3e2ef45c336a9410b90ace52
https://doi.org/10.1111/imig.12847/v4/response1
https://doi.org/10.1111/imig.12847/v4/response1
Autor:
John H. Griffin, Sumra Nazir, Christian Besler, Berend Isermann, Ihsan Gadi, Rajiv Rana, Jayakumar Manoharan, Moh'd Mohanad Al-Dabet, Ronald Biemann, Shrey Kohli, Fabian Bock, Markus Scholz, Robert Geffers, Bernhard Nieswandt, Charles T. Esmon, Ruediger C. Braun-Dullaeus, Khurrum Shahzad, Sameen Fatima, Ahmed Elwakiel, Dheerendra Gupta
Publikováno v:
Circ Res
Rationale: While thrombin is the key protease in thrombus formation, other coagulation proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate intracellular signaling via partially distinct receptors. Objectives: To st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dc6bcc8a96cc13c398a5294723cf6c
https://europepmc.org/articles/PMC8293866/
https://europepmc.org/articles/PMC8293866/
Autor:
Moh'd Mohanad Al-Dabet, Franziska Lochmann, Shrey Kohli, Satish Ranjan, Berend Isermann, Paulina Markmeyer
Publikováno v:
Science meets clinical practice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393a61b5c3b7c20859445b090c0ecbf4
https://doi.org/10.1055/s-0039-1680084
https://doi.org/10.1055/s-0039-1680084
Autor:
Moh′d Mohanad Al‐Dabet, Lorenz Schild, Juliane Wolter, Christian Mawrin, Fabian Bock, Raik Rönicke, Karl‐Uwe Petersen, Peter P. Nawroth, Berend Isermann, Satish Ranjan, Khurrum Shahzad, Andrea Hellwig, Ihsan Gadi
Publikováno v:
Journal of Thrombosis and Haemostasis. 14:2212-2226
SummaryBackground Studies with human samples and in rodents established a function of coagulation proteases in neuro-inflammatory demyelinating diseases, e.g. in multiple sclerosis (MS) and experimental autoimmune encephalitis (EAE). Surprisingly, ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c0e4b17453868f9b264dce572159b1
https://doi.org/10.1111/jth.13494
https://doi.org/10.1111/jth.13494