Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Moganaden Moorghen"'
Autor:
Jennifer R Bailey, Paul W Bland, John F Tarlton, Iain Peters, Moganaden Moorghen, Paul A Sylvester, Christopher S J Probert, Christine V Whiting
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52332 (2012)
BACKGROUND: Fibrosis is a serious consequence of Crohn's disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. METHODS: Factors potentially
Externí odkaz:
https://doaj.org/article/1e7df736dc304894b52eb94c48219eca
Autor:
C Paraskeva, Ann C. Williams, Diane J. Hicks, Moganaden Moorghen, Catherine A. Wallam, Alexander Greenhough
Publikováno v:
Oncogene
Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE(2)) occur in the majority of colorectal cancers and have important roles in colorectal tumorigenesis. However, despite the established prosu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb324ef1c259b437278044f2a08c8cd
https://doi.org/10.1038/onc.2010.94
https://doi.org/10.1038/onc.2010.94
Autor:
Graham Packham, Kieron D. Edwards, Moganaden Moorghen, Tracey J Collard, Angela Hague, Ann C. Williams, Samantha L Southern, Christos Paraskeva, Nadine K. Clemo
Publikováno v:
Carcinogenesis. 29:849-857
Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we show for the first time that BAG-1 is over-expressed in medium/large-sized colorectal adenomas a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d8ec104c8dedce2f08d7ed437356ae
https://doi.org/10.1093/carcin/bgn004
https://doi.org/10.1093/carcin/bgn004
Autor:
Moganaden Moorghen, Massimo Pignatelli, Christos Paraskeva, David Qualtrough, Nahida A. Banu, Andrea Buda, Dje Elder, SD Chell
Publikováno v:
Cell Proliferation. 40:768-779
The use of non‐steroidal anti‐inflammatory drugs has proved of great interest in the prevention and treatment of colorectal cancer, although their precise mechanisms of action remain unclear. Overexpression of cyclooxygenase‐2 (COX‐2) and sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35c8d6fa6cc32f25a8cf632f4234a35
https://doi.org/10.1111/j.1365-2184.2007.00459.x
https://doi.org/10.1111/j.1365-2184.2007.00459.x
Autor:
Derek Alderson, Roger Feakins, P.B. Savage, Jyoti Gupta, Jeffrey M P Holly, Moganaden Moorghen, Andrew Hollowood, P.V. Newcomb, Zun-Wu Zhang
Publikováno v:
Cancer Causes & Control. 15:211-218
IGF family proteins play a pivotal role in regulating cell growth and apoptosis in normal and tumour tissues. IGFBP-3 is the major binding protein of IGFs and modulates the bioactivity of IGFs. To examine the role of IGFBP-3 in gastric cancer, an IGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9867c5672bfa96c930a363bfac5a6c7
https://doi.org/10.1023/b:caco.0000019510.96285.e9
https://doi.org/10.1023/b:caco.0000019510.96285.e9
Autor:
Zun-Wu Zhang, Derek Alderson, Jeffrey M P Holly, Roger Feakins, Michael J.G. Farthing, Nicola J. Laurence, Andrew Hollowood, Jyoti Gupta, P.V. Newcomb, Moganaden Moorghen
Publikováno v:
Clinical Cancer Research. 10:131-135
Purpose: A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e4cbdade89ee1a70716e61eb8896f6
https://doi.org/10.1158/1078-0432.ccr-0853-3
https://doi.org/10.1158/1078-0432.ccr-0853-3
Publikováno v:
The Journal of Pathology. 198:428-434
Non-steroidal anti-inflammatory drugs are chemopreventive for colorectal cancer. This effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX-2). However, the cellular expression and role of COX-2 in the premali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96695fc2a97023c3d6a6659d50ca7971
https://doi.org/10.1002/path.1232
https://doi.org/10.1002/path.1232
Autor:
Chris Probert, P A Sylvester, John F Tarlton, Christine V. Whiting, Iain R. Peters, Moganaden Moorghen, Paul W. Bland, Jennifer R Bailey
Publikováno v:
PLoS ONE
University of Bristol-PURE
PLoS ONE, Vol 7, Iss 12, p e52332 (2012)
University of Bristol-PURE
PLoS ONE, Vol 7, Iss 12, p e52332 (2012)
Background Fibrosis is a serious consequence of Crohn’s disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. Methods Factors potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53921c92687602232d62804e2498ec8
http://europepmc.org/articles/PMC3534115
http://europepmc.org/articles/PMC3534115
Autor:
Massimo Pignatelli, Jennifer Baker, Richard S. Daly, Moganaden Moorghen, Andrea Buda, Nahida A. Banu
Publikováno v:
Cell communicationadhesion. 18(1-2)
Cyclooxygenase (COX)-2 is a key molecular target of colon cancer prevention. However, the mechanisms by which COX-2 inhibitors confer protective effects against tumour development are not completely understood. The aim of this study was to elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f003f8fb5edba4ac76fab6b9c4ad9b3
https://pubmed.ncbi.nlm.nih.gov/21679035
https://pubmed.ncbi.nlm.nih.gov/21679035
Autor:
Zun-Wu, Zhang, Paul, Newcomb, Andrew, Hollowood, Roger, Feakins, Moganaden, Moorghen, Alan, Storey, Michael J G, Farthing, Derek, Alderson, Jeff, Holly
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(6)
A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility and prognosis. To examine the role of the polymorphism in the gastric adenocarcinoma, we examined 397 patients with or without th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e8de992d95215c32745579f0a60a8a1
https://pubmed.ncbi.nlm.nih.gov/12796380
https://pubmed.ncbi.nlm.nih.gov/12796380