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pro vyhledávání: '"Moez Bali"'
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35563 (2012)
5-HT3A receptors are pentameric neurotransmitter-gated ion channels in the Cys-loop receptor family. Each subunit contains an extracellular domain, four transmembrane segments (M1, M2, M3, M4) and a 115 residue intracellular loop between M3 and M4. I
Externí odkaz:
https://doaj.org/article/16c45612e78e4966bed0ff339634e9f6
Publikováno v:
Journal of Biological Chemistry. 286:14098-14109
GLIC is a homopentameric proton-gated, prokaryotic homologue of the Cys loop receptor family of neurotransmitter-gated ion channels. Recently, crystal structures of GLIC hypothesized to represent an open channel state were published. To explore the c
Publikováno v:
The Journal of Neuroscience. 29:3083-3092
The molecular basis of general anesthetic interactions with GABA(A) receptors is uncertain. An accurate homology model would facilitate studies of anesthetic action. Construction of a GABA(A) model based on the 4 A resolution acetylcholine receptor s
Publikováno v:
The Journal of General Physiology
Cys-loop receptor neurotransmitter-gated ion channels are pentameric assemblies of subunits that contain three domains: extracellular, transmembrane, and intracellular. The extracellular domain forms the agonist binding site. The transmembrane domain
Autor:
Moez Bali, Myles H. Akabas
Publikováno v:
International Congress Series. 1283:3-8
The GABA A receptor is a major target of the intravenous anesthetic propofol. In order to obtain an understanding of propofol's actions at a molecular level we have attempted to identify the propofol binding site and the conformational changes that p
Publikováno v:
The Journal of Neuroscience. 25:9358-9366
Based on theTorpedoacetylcholine receptor structure, Unwin and colleagues (Miyazawa et al., 2003; Unwin, 2005) hypothesized that the transduction of agonist binding to channel gate opening involves a “pin-into-socket” interaction between αV46 at
Publikováno v:
American Journal of Physiology-Cell Physiology. 280:C1588-C1598
The almost ubiquitously expressed ClC-2 chloride channel is activated by hyperpolarization and osmotic cell swelling. Osmotic swelling also activates a different class of outwardly rectifying chloride channels, and several reports point to a link bet
Autor:
S. Randall Thomas, Moez Bali
Publikováno v:
Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 324:185-199
Though feedforward activation (FA) is a little known principle of control in metabolic networks, there is one well-known example; namely, the activation of pyruvate kinase (PK) by fructose-1,6-biphosphate (FBP) in glycolysis. The effects of this acti
Autor:
Myles H. Akabas, Moez Bali
GABA(A) receptors mediate fast inhibitory synaptic transmission. The transmembrane ion channel is lined by a ring of five α helices, M2 segments, one from each subunit. An outer ring of helices comprising the alternating M1, M3, and M4 segments from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca83551072a114bf30d2e53616785eb
https://europepmc.org/articles/PMC3431678/
https://europepmc.org/articles/PMC3431678/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e35563 (2012)
PLoS ONE, Vol 7, Iss 4, p e35563 (2012)
5-HT3A receptors are pentameric neurotransmitter-gated ion channels in the Cys-loop receptor family. Each subunit contains an extracellular domain, four transmembrane segments (M1, M2, M3, M4) and a 115 residue intracellular loop between M3 and M4. I