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New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats.

Autor: Walles M; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.) markus.walles@novartis.com., Rudolph B; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Wolf T; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Bourgailh J; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Suetterlin M; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Moenius T; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Peraus G; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Heudi O; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Elbast W; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Lanshoeft C; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.)., Bilic S; Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland (M.W, B.R., T.W., J.B., M.S., T.M., G.P., O.H., W.E., C.L.); and Translational Clinical Oncology, East Hannover, New Jersey (S.B.).

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Jul; Vol. 44 (7), pp. 897-910. Date of Electronic Publication: 2016 Apr 27.

9^th Conference of the Central European Division e.V. of the International Isotope Society.

Autor: Andres, Hendrik, Sidorov, G.V., Zverkov, Yu.B., Myasoedov, N.F., Cimpoia, A.R., Susan, A.B., Saljoughian, Manouchehr, Morimoto, Hiromi, Williams, Philip G., Than, Chit, Salter, R, Moenius, T, Ackermann, P, Studer, M, Morgan, A, Chappelle, M, Konstantinova, Olga V., Khripach, Vladimir A., Zhabinskii, Vladimir N., Antonchick, Andrey P.

Publikováno v: Journal of Labelled Compounds & Radiopharmaceuticals; Nov2001, Vol. 44 Issue 13, p947-985, 39p