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Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Autor: Johnson HWB; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., Lowe E; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., Anderl JL; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., Fan A; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., Muchamuel T; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., Bowers S; Onyx Pharmaceuticals, an Amgen Subsidiary , South San Francisco , California 94080 , United States., Moebius DC; Onyx Pharmaceuticals, an Amgen Subsidiary , South San Francisco , California 94080 , United States., Kirk C; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States., McMinn DL; Kezar Life Sciences , 4000 Shoreline Court, Suite 300 , South San Francisco , California 94080 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11127-11143. Date of Electronic Publication: 2018 Dec 11.

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Akademický článek

Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.

Autor: Johnson HWB; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States., Anderl JL; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States., Bradley EK; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Bui J; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Jones J; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Arastu-Kapur S; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Kelly LM; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Lowe E; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States., Moebius DC; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., Muchamuel T; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States., Kirk C; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States., Wang Z; Onyx Pharmaceuticals, An Amgen Subsidiary, 249 East Grand Avenue, South San Francisco, California 94080, United States., McMinn D; Kezar Life Sciences, 300 Utah Avenue, Suite 105, South San Francisco, California 94080, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Mar 09; Vol. 8 (4), pp. 413-417. Date of Electronic Publication: 2017 Mar 09 (Print Publication: 2017).

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Akademický článek

Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin.

Autor: Sparling BA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02139, United States., Tucker JK; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02139, United States., Moebius DC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02139, United States., Shair MD; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02139, United States.

Publikováno v: Organic letters [Org Lett] 2015 Jul 17; Vol. 17 (14), pp. 3398-401. Date of Electronic Publication: 2015 Jun 30.

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Akademický článek

Catalysis of diazoalkane-carbonyl homologation. How new developments in hydrazone oxidation enable the carbon insertion strategy for synthesis.

Autor: Moebius DC; Onyx Pharmaceuticals, Inc., 249 E. Grand Avenue, South San Francisco, CA, 94080, USA., Rendina VL, Kingsbury JS

Publikováno v: Topics in current chemistry [Top Curr Chem] 2014; Vol. 346, pp. 111-62.

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Akademický článek

Enantioselective total synthesis of hyperforin.

Autor: Sparling BA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA., Moebius DC, Shair MD

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2013 Jan 16; Vol. 135 (2), pp. 644-7. Date of Electronic Publication: 2012 Dec 31.

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Akademický článek

An enantioselective synthesis of 2-aryl cycloalkanones by Sc-catalyzed carbon insertion.

Autor: Rendina VL; Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA., Moebius DC, Kingsbury JS

Publikováno v: Organic letters [Org Lett] 2011 Apr 15; Vol. 13 (8), pp. 2004-7. Date of Electronic Publication: 2011 Mar 14.

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Akademický článek

Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to beta-ketosilane or enolsilane adducts.

Autor: Dabrowski JA; Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA., Moebius DC, Wommack AJ, Kornahrens AF, Kingsbury JS

Publikováno v: Organic letters [Org Lett] 2010 Aug 20; Vol. 12 (16), pp. 3598-601.

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Akademický článek

Diverse alkanones by catalytic carbon insertion into the formyl C-H bond. Concise access to the natural precursor of achyrofuran.

Autor: Wommack AJ; Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA., Moebius DC, Travis AL, Kingsbury JS

Publikováno v: Organic letters [Org Lett] 2009 Aug 06; Vol. 11 (15), pp. 3202-5.

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