Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Moe Tamura"'
Autor:
Emi Sugimoto, Jingmei Li, Yasutaka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Shiori Shikata, Wenyu Zhang, Keita Yamamoto, Kimihito Cojin Kawabata, Tatsuya Kawase, Takeshi Saito, Taku Yoshida, Satoshi Yamazaki, Yuta Kaito, Yoichi Imai, Tamami Denda, Yasunori Ota, Tomofusa Fukuyama, Yosuke Tanaka, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML is slower in Rag2 −/− mic
Externí odkaz:
https://doaj.org/article/5b6b8d5e72fb4e78b3b3547dd6332877
Autor:
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and pe
Externí odkaz:
https://doaj.org/article/7fee3de7cd6b4b10b237a1df0b62b1d6
Autor:
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Leukemic stem cells (LSCs) in chronic myeloid leukemia are resistant to imatinib and therefore are a cause of relapse. The authors show that IRAK1/4-NF-κB-PD-L1 signaling is critical to mediate imatinib resistance in LSCs and that combining imatinib
Externí odkaz:
https://doaj.org/article/c3477c962caf480e9537b3db7eabd49c
Autor:
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Inosine monophosphate dehydrogenase (IMPDH) is a rate‐limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven
Externí odkaz:
https://doaj.org/article/80b4174013704cb29ecfb11251a79951
Autor:
Yasutaka Hayashi, Susumu Goyama, XiaoXiao Liu, Moe Tamura, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, Satoshi Yamazaki, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Koichi Matsuda, Goro Sashida, Hitoshi Takizawa, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.
Externí odkaz:
https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
Autor:
Motohiro Kato, Susumu Goyama, Nobutaka Kiyokawa, Kenichiro Hata, Kimikazu Matsumoto, Toshio Kitamura, Seishi Ogawa, Takeshi Inukai, Junko Takita, Kentaro Ohki, Masafumi Seki, Ryota Shirai, Hitomi Ueno-Yokohata, Hiroe Kizawa, Toru Uchiyama, Hiroko Ogata-Kawata, Masahiro Migita, Kazuko Hamamoto, Shohei Yamamoto, Tsukasa Hori, Hiroyuki Takahashi, Akihiro Watanabe, Daisuke Tomizawa, Masanori Yoshida, Kohji Okamura, Kazuhiko Nakabayashi, Meri Uchiyama, Moe Tamura, Shin-ichi Tsujimoto, Tomoo Osumi
Translocations of retinoic acid receptor-α (RARA), typically PML–RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without RARA tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a48a08deebf9face976104eb1bf03c3
https://doi.org/10.1158/0008-5472.c.6510653.v1
https://doi.org/10.1158/0008-5472.c.6510653.v1
Autor:
Motohiro Kato, Susumu Goyama, Nobutaka Kiyokawa, Kenichiro Hata, Kimikazu Matsumoto, Toshio Kitamura, Seishi Ogawa, Takeshi Inukai, Junko Takita, Kentaro Ohki, Masafumi Seki, Ryota Shirai, Hitomi Ueno-Yokohata, Hiroe Kizawa, Toru Uchiyama, Hiroko Ogata-Kawata, Masahiro Migita, Kazuko Hamamoto, Shohei Yamamoto, Tsukasa Hori, Hiroyuki Takahashi, Akihiro Watanabe, Daisuke Tomizawa, Masanori Yoshida, Kohji Okamura, Kazuhiko Nakabayashi, Meri Uchiyama, Moe Tamura, Shin-ichi Tsujimoto, Tomoo Osumi
Supplementary Methods: IRB approval, Genomic analysis, Identification of translocations and determination of their breakpoints, Plasmids Construct, Cell line and reagent, Co-immunoprecipotation and immunoblotting analysis, Luciferase assay, Retroviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c87a9fa2073a3585c3ebb31a2e68bc2
https://doi.org/10.1158/0008-5472.22420451.v1
https://doi.org/10.1158/0008-5472.22420451.v1
Autor:
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Publikováno v:
EMBO molecular medicineReferences.
Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven in the clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1794d97dd2d4857c2bef277c60e3907
https://pubmed.ncbi.nlm.nih.gov/36453131
https://pubmed.ncbi.nlm.nih.gov/36453131
Autor:
Emi Sugimoto, Yasutakka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Kimihito Kawabata, Tatsuya Kawase, Takeshi Saito, Taku Yoshida, Satoshi Yamazaki, Yuta Kaito, Yoich Imai, Tomofusa Fukuyama, Yosuke Tanaka, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML was retarded in Rag2-/- mice despite t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261706dee1da5855ecd23c455afe8fdd
https://doi.org/10.21203/rs.3.rs-1934697/v1
https://doi.org/10.21203/rs.3.rs-1934697/v1
Autor:
Satoshi Yamazaki, Tomofusa Fukuyama, Benjamin Mizukawa, Tatsuhiro Shibata, Eric O'Brien, Y Hayashi, Yosuke Tanaka, Xiaoxiao Liu, Goro Sashida, Hitoshi Takizawa, Akiko Matsumoto, Susumu Goyama, Shuhei Asada, Toshio Kitamura, Mark Wunderlich, Koichi Matsuda, Moe Tamura, Satoshi Yamasaki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The negative regulator of p53, MDM2, is frequently overexpressed in acute myeloid leukemia (AML) that retains wild-type TP53 alleles. Targeting of p53-MDM2 interaction to reactivate p53 function is therefore an attractive therapeutic approach for AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8d38a94a11f46897e80c6dfe9491e1
https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79