Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Moe R. Mahjoub"'
Autor:
Michael Lewis, Berta Terré, Philip A. Knobel, Tao Cheng, Hao Lu, Camille Stephan-Otto Attolini, Jordann Smak, Etienne Coyaud, Isabel Garcia-Cao, Shalu Sharma, Chithran Vineethakumari, Jessica Querol, Gabriel Gil-Gómez, Gabriele Piergiovanni, Vincenzo Costanzo, Sandra Peiró, Brian Raught, Haotian Zhao, Xavier Salvatella, Sudipto Roy, Moe R. Mahjoub, Travis H. Stracker
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-15 (2023)
Abstract Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequenti
Externí odkaz:
https://doaj.org/article/6a20ac16e16e4c6f9816cfefaef6e20f
Autor:
Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K. Dutcher, Steven L. Brody
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 g
Externí odkaz:
https://doaj.org/article/a8958a20c7784cb38752182a624f9384
Autor:
Mathew Bowler, Dong Kong, Shufeng Sun, Rashmi Nanjundappa, Lauren Evans, Veronica Farmer, Andrew Holland, Moe R. Mahjoub, Haixin Sui, Jadranka Loncarek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The formation of cilia depends on centriole’s distal appendages. Here, the authors use correlative 3D-superresolution, electron microscopy and electron tomography to detail the architecture of distal appendages, to describe the initial stages of ap
Externí odkaz:
https://doaj.org/article/488ce455ae8b4d4ab0d73c6a0e625153
Publikováno v:
bioRxiv
SummaryDefective centrosome function can disrupt embryonic kidney development, by causing changes to the renal interstitium that leads to fibrocystic disease pathologies. Yet, it remains unknown how mutations in centrosome genes impact kidney interst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e3a772ebb6eee9bcfa755ec9c48be5
https://doi.org/10.1101/2023.04.04.535583
https://doi.org/10.1101/2023.04.04.535583
Publikováno v:
bioRxiv
SummaryMutations that disrupt centrosome structure or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet, it remains unclear how mutations in proteins essential for centrosome biogenesis impact embryonic kidney de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2186d1b7668fe46bdde1eafceb43b902
https://europepmc.org/articles/PMC10104032/
https://europepmc.org/articles/PMC10104032/
Autor:
Rashmi Nanjundappa, Dong Kong, Kyuhwan Shim, Tim Stearns, Steven L Brody, Jadranka Loncarek, Moe R Mahjoub
Publikováno v:
eLife, Vol 8 (2019)
Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification. Yet, how MCC regulate the precise n
Externí odkaz:
https://doaj.org/article/5a68320272924f5abb170e38879bcc9e
Autor:
Lynne M. Quarmby, Moe R. Mahjoub
Publikováno v:
The Chlamydomonas Sourcebook ISBN: 9780128225080
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212ca3e49c22b033f098de5e12bfcfd4
https://doi.org/10.1016/b978-0-12-822508-0.00010-1
https://doi.org/10.1016/b978-0-12-822508-0.00010-1
Autor:
Lea M. Alford, Prachee Avasthi, Mayanka Awasthi, Philip V. Bayly, Robert A. Bloodgood, Alan Brown, Khanh Huy Bui, Dario Cortese, Carol Dieckmann, Dennis Diener, Susan K. Dutcher, Paul Guichard, Virginie Hamel, Peter Hegemann, Masafumi Hirono, Ritsu Kamiya, Stephen M. King, Georg Kreimer, Karl Lechtreck, Paul A. Lefebvre, Esben Lorentzen, Moe R. Mahjoub, David R. Mitchell, Daniela Nicastro, Masayuki Onishi, Junmin Pan, Mary E. Porter, Lynne M. Quarmby, Peeyush Ranjan, Winfield S. Sale, William J. Snell, Ken-ichi Wakabayashi, Kirsty Y. Wan, Maureen Wirschell, George B. Witman, Louis G. Woodhams, Toshiki Yagi, Ryosuke Yamamoto, Pinfen Yang, Yanhe Zhao
Publikováno v:
The Chlamydomonas Sourcebook ISBN: 9780128225080
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::145359ceb52fe8396439fc8ca2abb5ba
https://doi.org/10.1016/b978-0-12-822508-0.00022-8
https://doi.org/10.1016/b978-0-12-822508-0.00022-8
Autor:
Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited monogenic disorder accounting for ∼5% of patients with renal failure. Yet, therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display defects in the biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb056589be2b0f77fa48f1e9f146c0d5
https://doi.org/10.1101/2022.11.16.516801
https://doi.org/10.1101/2022.11.16.516801
Publikováno v:
eLife, Vol 7 (2018)
The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show
Externí odkaz:
https://doaj.org/article/367da7e2caf44df0bdabb4d4f66e45b6