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Akademický článek

Bartonella quintana Infection in Kidney Transplant Recipients from Donor Experiencing Homelessness, United States, 2022

Publikováno v: Emerging Infectious Diseases, Vol 30, Iss 12, Pp 2467-2475 (2024)

Bartonella quintana infection can cause severe disease that includes clinical manifestations such as endocarditis, chronic bacteremia, and vasoproliferative lesions of the skin and viscera. B. quintana bacteria is transmitted by the human body louse

Externí odkaz: https://doaj.org/article/e80ec11ec45145c9943bdc90cb8a62cf

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Akademický článek

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-15 (2023)

Abstract Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequenti

Externí odkaz: https://doaj.org/article/6a20ac16e16e4c6f9816cfefaef6e20f

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Akademický článek

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

Autor: Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K. Dutcher, Steven L. Brody

Publikováno v: JCI Insight, Vol 8, Iss 11 (2023)

DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 g

Externí odkaz: https://doaj.org/article/a8958a20c7784cb38752182a624f9384

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Akademický článek

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

Autor: Mathew Bowler, Dong Kong, Shufeng Sun, Rashmi Nanjundappa, Lauren Evans, Veronica Farmer, Andrew Holland, Moe R. Mahjoub, Haixin Sui, Jadranka Loncarek

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The formation of cilia depends on centriole’s distal appendages. Here, the authors use correlative 3D-superresolution, electron microscopy and electron tomography to detail the architecture of distal appendages, to describe the initial stages of ap

Externí odkaz: https://doaj.org/article/488ce455ae8b4d4ab0d73c6a0e625153

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Akademický článek

Regulation of cilia abundance in multiciliated cells

Autor: Rashmi Nanjundappa, Dong Kong, Kyuhwan Shim, Tim Stearns, Steven L Brody, Jadranka Loncarek, Moe R Mahjoub

Publikováno v: eLife, Vol 8 (2019)

Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification. Yet, how MCC regulate the precise n

Externí odkaz: https://doaj.org/article/5a68320272924f5abb170e38879bcc9e

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Akademický článek

A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

Autor: Ewelina Betleja, Rashmi Nanjundappa, Tao Cheng, Moe R Mahjoub

Publikováno v: eLife, Vol 7 (2018)

The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show

Externí odkaz: https://doaj.org/article/367da7e2caf44df0bdabb4d4f66e45b6

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