A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

Autor: Bangi, Erdem, Smibert, Peter, Uzilov, Andrew V., Teague, Alexander G., Gopinath, Sindhura, Antipin, Yevgeniy, Chen, Rong, Hecht, Chana, Gruszczynski, Nelson, Yon, Wesley J., Malyshev, Denis, Laspina, Denise, Selkridge, Isaiah, Wang, Huan, Gomez, Jorge, Mascarenhas, John, Moe, Aye S., Lau, Chun Yee, Taik, Patricia, Pandya, Chetanya, Sung, Max, Kim, Sara, Yum, Kendra, Sebra, Robert, Donovan, Michael, Misiukiewicz, Krzysztof, Ang, Celina, Schadt, Eric E., Posner, Marshall R., Cagan, Ross L.

Publikováno v: In iScience 19 March 2021 24(3)

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Identification of a novel RASD1 somatic mutation in a USP8 -mutated corticotroph adenoma.

Autor: Uzilov AV; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Cheesman KC; Division of Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Fink MY; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Newman LC; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Pandya C; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Lalazar Y; Division of Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Hefti M; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Fowkes M; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Deikus G; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Lau CY; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Moe AS; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Kinoshita Y; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Kasai Y; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Zweig M; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Gupta A; Division of Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Starcevic D; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mahajan M; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Schadt EE; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Post KD; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Donovan MJ; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Sebra R; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Chen R; Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Geer EB; Division of Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering, New York, New York 10065, USA.

Publikováno v: Cold Spring Harbor molecular case studies [Cold Spring Harb Mol Case Stud] 2017 May; Vol. 3 (3), pp. a001602.