Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Modesto Rojas"'
Autor:
Ammar A. Abdelrahman, Porsche V. Sandow, Jing Wang, Zhimin Xu, Modesto Rojas, John S. Bomalaski, Tahira Lemtalsi, Ruth B. Caldwell, Robert W. Caldwell
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102020- (2024)
Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stab
Externí odkaz:
https://doaj.org/article/c237de2e14d94104aab7e234e7dfe042
Autor:
Abdelrahman Y. Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha, Tahira Lemtalsi, Chintan Patel, Ji Xing, Syed A. Zaidi, Wenbo Zhi, Brain K. Stansfield, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Current therapies for treatment of proliferative retinopathy focus on retinal neovascularization (RNV) during advanced disease and can trigger adverse side-effects. Here, we have tested a new strategy for limiting neurovascular injury and pr
Externí odkaz:
https://doaj.org/article/9425c35153c5408eae0768802d3f931a
Autor:
Esraa Shosha, Luke Qin, Tahira Lemtalsi, Syed A. H. Zaidi, Modesto Rojas, Zhimin Xu, Robert William Caldwell, Ruth B. Caldwell, Abdelrahman Y. Fouda
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Diabetic retinopathy (DR) is the leading cause of vision loss in working age adults. Understanding the retinal metabolic response to circulating high glucose levels in diabetic patients is critical for development of new therapeutics to treat DR. Mea
Externí odkaz:
https://doaj.org/article/25b0ec4ab768404b8dea9721d36dfb40
Autor:
Zhimin Xu, Abdelrahman Y. Fouda, Tahira Lemtalsi, Esraa Shosha, Modesto Rojas, Fang Liu, Chintan Patel, R. William Caldwell, Subhadra Priya Narayanan, Ruth B. Caldwell
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Our previous studies have implicated expression of the mitochondrial isoform of the arginase enzyme arginase 2 (A2) in neurovascular injury during ischemic retinopathies. The aim of this study was to characterize the specific involvement of A2 in ret
Externí odkaz:
https://doaj.org/article/3ba55fe49f214d8f8b5800625616fdda
Autor:
Modesto Rojas, Tahira Lemtalsi, Haroldo A. Toque, Zhimin Xu, David Fulton, Robert William Caldwell, Ruth B. Caldwell
Publikováno v:
Antioxidants, Vol 6, Iss 2, p 43 (2017)
Increases in reactive oxygen species (ROS) and decreases in nitric oxide (NO) have been linked to vascular dysfunction during diabetic retinopathy (DR). Diabetes can reduce NO by increasing ROS and by increasing activity of arginase, which competes w
Externí odkaz:
https://doaj.org/article/2112a2745e16432db13f53215b878068
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110604 (2014)
Hyperoxia exposure of premature infants causes obliteration of the immature retinal microvessels, leading to a condition of proliferative vitreoretinal neovascularization termed retinopathy of prematurity (ROP). Previous work has demonstrated that th
Externí odkaz:
https://doaj.org/article/f713b670ea2d48618081d0eb61ae3b5f
Autor:
Modesto Rojas, Wenbo Zhang, Zhimin Xu, Tahira Lemtalsi, Phillip Chandler, Haroldo A Toque, Robert W Caldwell, Ruth B Caldwell
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84357 (2013)
Diabetic retinopathy, a major cause of blindness, is characterized by increased expression of vascular endothelial growth factor (VEGF), leukocyte attachment to the vessel walls and increased vascular permeability. Previous work has shown that reacti
Externí odkaz:
https://doaj.org/article/777cf138cdba4b2096d747dc27de982f
Autor:
David J. Fulton, Hanfang Zhang, Farlyn Z. Hudson, Brian K. Stansfield, Modesto Rojas, Rebekah Tritz, Chintan Patel, Zsuzsanna Bordan, Stephen Haigh, Zhimin Xu, David A. Ingram, Ruth B. Caldwell, Neal L. Weintraub
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dysplasia in the ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376a8b81286f5d06021acb103d3d56db
http://europepmc.org/articles/PMC5963003
http://europepmc.org/articles/PMC5963003
Autor:
William Caldwell, Abdelrahman Y. Fouda, Fang Liu, Modesto Rojas, Tahira Lemtalsi, Priya Narayanan, Esraa Shosha, Ruth B. Caldwell, Zhimin Xu
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90f032db3d82c03ad78502b51aa143a6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.665.10
https://doi.org/10.1096/fasebj.2019.33.1_supplement.665.10
Autor:
Ji Xing, Tahira Lemtalsi, R. William Caldwell, Zhimin Xu, Esraa Shosha, Ruth B. Caldwell, S. Priya Narayanan, Abdelrahman Y. Fouda, Modesto Rojas, David Fulton
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1215 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1215
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1215
We have recently found that diabetes-induced premature senescence of retinal endothelial cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase enzyme arginase 1 (A1). Here, we used genetic strategies to determine the speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d8caa1e9e7e9567a77db5ede12c56e
http://www.mdpi.com/1422-0067/19/4/1215
http://www.mdpi.com/1422-0067/19/4/1215