Zobrazeno 1 - 10
of 543
pro vyhledávání: '"Modesto Orozco"'
Autor:
Matilde Murga, Gema Lopez-Pernas, Robert Soliva, Elena Fueyo-Marcos, Corina Amor, Ignacio Faustino, Marina Serna, Alicia G. Serrano, Lucía Díaz, Sonia Martínez, Carmen Blanco-Aparicio, Marta Elena Antón, Brinton Seashore-Ludlow, Joaquín Pastor, Rozbeh Jafari, Miguel Lafarga, Oscar Llorca, Modesto Orozco, Oscar Fernández-Capetillo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-11 (2024)
Abstract SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors, which were discovered while trying to identify
Externí odkaz:
https://doaj.org/article/954f96d3983d491f8d462549b44cbd7d
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012173 (2024)
Interactive Jupyter Notebooks in combination with Conda environments can be used to generate FAIR (Findable, Accessible, Interoperable and Reusable/Reproducible) biomolecular simulation workflows. The interactive programming code accompanied by docum
Externí odkaz:
https://doaj.org/article/3d06dcac195746eab6375d2b780d6aec
Autor:
Joan Pous, Blazej Baginski, Pau Martin-Malpartida, Lorena González, Margherita Scarpa, Eric Aragon, Lidia Ruiz, Rebeca A. Mees, Javier Iglesias-Fernández, Modesto Orozco, Angel R. Nebreda, Maria J. Macias
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrate
Externí odkaz:
https://doaj.org/article/5db9dbcc41a443aea05c543a36e1e73e
Autor:
Nikolaos Parisis, Pablo D. Dans, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Diego Molina-Serrano, Isabelle Brun-Heath, Denisa Hendrychová, Suman Kumar Maity, Diana Buitrago, Rafael Lema, Thiziri Nait Achour, Simona Giunta, Michael Girardot, Nicolas Talarek, Valérie Rofidal, Katerina Danezi, Damien Coudreuse, Marie-Noëlle Prioleau, Robert Feil, Modesto Orozco, Ashraf Brik, Pei-Yun Jenny Wu, Liliana Krasinska, Daniel Fisher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Histone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57 pho
Externí odkaz:
https://doaj.org/article/aae698efdb56403c8aba30b80d3ec197
Autor:
Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Margherita Scarpa, Isabelle Brun-Heath, Ana Igea, Pau Martin-Malpartida, Lidia Ruiz, Chiara Pallara, Mauricio Esguerra, Francesco Colizzi, Cristina Mayor-Ruiz, Ricardo M. Biondi, Robert Soliva, Maria J. Macias, Modesto Orozco, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disord
Externí odkaz:
https://doaj.org/article/875e0b5f72914dd0a22c1161dc475f7f
Autor:
Roberto El-Khoury, Veronica Macaluso, Christopher Hennecker, Anthony K. Mittermaier, Modesto Orozco, Carlos González, Miguel Garavís, Masad J. Damha
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
The oligonucleotide d(TC5) forms a well-characterized tetrameric i-motif in solution; however, the isolation of dimeric and trimeric intermediates remains challenging. Here, the authors report that 2′-deoxy-2′-fluoroarabinocytidine substitutions
Externí odkaz:
https://doaj.org/article/4633b3ce480d4d24a7df7ba24c55d47e
Autor:
Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B. Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
Externí odkaz:
https://doaj.org/article/0ea4c921c75c4f04849c5efbc9071b23
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105981- (2023)
Summary: Omicron BA.1 is a highly infectious variant of SARS-CoV-2 that carries more than thirty mutations on the spike protein in comparison to the Wuhan wild type (WT). Some of the Omicron mutations, located on the receptor-binding domain (RBD), ar
Externí odkaz:
https://doaj.org/article/db5b75879f39408fab09ff4eefe3bdc5
Autor:
Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P Mata, James Krieger, Paula Ruiz-Rodriguez, Maria Luisa López-Redondo, Clara Francés-Gómez, Roberto Melero, Carlos Óscar Sánchez-Sorzano, Marta Martínez, Nadine Gougeard, Alicia Forcada-Nadal, Sara Zamora-Caballero, Roberto Gozalbo-Rovira, Carla Sanz-Frasquet, Rocío Arranz, Jeronimo Bravo, Vicente Rubio, Alberto Marina, IBV-Covid19-Pipeline, Ron Geller, Iñaki Comas, Carmen Gil, Mireia Coscolla, Modesto Orozco, José Luis Llácer, Jose-Maria Carazo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010995 (2022)
[This corrects the article DOI: 10.1371/journal.ppat.1010631.].
Externí odkaz:
https://doaj.org/article/ba2f6b5305b14bfdb18ac6c0d06dd810
Autor:
Martino Bertoni, Miquel Duran-Frigola, Pau Badia-i-Mompel, Eduardo Pauls, Modesto Orozco-Ruiz, Oriol Guitart-Pla, Víctor Alcalde, Víctor M. Diaz, Antoni Berenguer-Llergo, Isabelle Brun-Heath, Núria Villegas, Antonio García de Herreros, Patrick Aloy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Small molecules bioactivity descriptors are enriched representations of compounds, reaching beyond chemical structures and capturing their known biological properties. Here the authors present a collection of deep neural networks able to infer bioact
Externí odkaz:
https://doaj.org/article/ea240240f3214f9098521acfd799be30