Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Modesto J. Remuiñán"'
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceee95809e2bca056e0d0c0c3d88cddd
https://doi.org/10.1126/scitranslmed.aaz6280
https://doi.org/10.1126/scitranslmed.aaz6280
Autor:
Modesto J Remuiñán, Esther Pérez-Herrán, Joaquín Rullás, Carlos Alemparte, María Martínez-Hoyos, David J Dow, Johnson Afari, Nalini Mehta, Jorge Esquivias, Elena Jiménez, Fátima Ortega-Muro, María Teresa Fraile-Gabaldón, Vickey L Spivey, Nicholas J Loman, Mark J Pallen, Chrystala Constantinidou, Douglas J Minick, Mónica Cacho, María José Rebollo-López, Carolina González, Verónica Sousa, Iñigo Angulo-Barturen, Alfonso Mendoza-Losana, David Barros, Gurdyal S Besra, Lluís Ballell, Nicholas Cammack
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60933 (2013)
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Externí odkaz:
https://doaj.org/article/a1f102d1746248ecb2619fd12d3505cf
Autor:
Katherine A Abrahams, Jonathan A G Cox, Vickey L Spivey, Nicholas J Loman, Mark J Pallen, Chrystala Constantinidou, Raquel Fernández, Carlos Alemparte, Modesto J Remuiñán, David Barros, Lluis Ballell, Gurdyal S Besra
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52951 (2012)
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Externí odkaz:
https://doaj.org/article/70f8999554ed40b5869a3d9e59113827
Autor:
Ana Guardia, Máire A. Convery, David Calvo, Feng Wang, Joaquín Rullas, Delia Blanco, Julia Castro-Pichel, Lydia Mata, Esther Pérez-Herrán, Robert J. Young, María Santos Martínez, Raquel Vida Fernández, Jesús Roque Campaña Gómez, Lluís Pagès, Gulcin Gulten, Alfonso Mendoza-Losana, Modesto J. Remuiñán, Marta León Alonso, James C. Sacchettini, Fátima Ortega
Publikováno v:
ChemMedChem. 11:687-701
Isoniazid (INH) remains one of the cornerstones of antitubercular chemotherapy for drug-sensitive strains of M. tuberculosis bacteria. However, the increasing prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d1d905239441b05fdf10ee9b7585b0
https://doi.org/10.1002/cmdc.201600020
https://doi.org/10.1002/cmdc.201600020
Autor:
Lourdes Encinas, Montserrat Ortega-Guerra, Ana Guardia, Joaquín Rullas, Esther Porras de Francisco, Juan Miguel-Siles, Cristina Rivero, Jorge Esquivias, Matthew H. Todd, Carlos Alemparte, Setshaba D. Khanye, Jessica Baiget, Raquel Vida Fernández, Winston Nxumalo, María Teresa Fraile-Gabaldón, Peter J. Rutledge, Esther Pérez-Herrán, Javier G. Osende, Modesto J. Remuiñán, Katrina A. Badiola, Marta León Alonso, Arancha Pérez, Ilaria Giordano, Elena Jimenez, Monica Cacho, Fátima Ortega
Publikováno v:
Journal of medicinal chemistry. 61(24)
Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The GlaxoSmithKline (GSK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2114d240443cf36d0bec882803efbb68
https://pubmed.ncbi.nlm.nih.gov/30457865
https://pubmed.ncbi.nlm.nih.gov/30457865
Autor:
Alfonso Mendoza, Cindy Richards, Modesto J. Remuiñán, Joaquín Rullas, Iñigo Angulo-Barturen, Delia Blanco, Ermias Woldu, Julia Castro, Esther Pérez-Herrán, Ruben Gonzalez Del Rio, Monica Cacho, María Jesús Vázquez-Muñiz, David Barros, Jose Luis Lavandera, Lluis Ballell, María Cleofé Zapatero-González
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1868-1875
One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba2bf7f6f3c37f4a5c61e948231996d
https://doi.org/10.1128/aac.03913-14
https://doi.org/10.1128/aac.03913-14
Autor:
Jonathan A. G. Cox, Joaquín Rullas, Katherine A. Abrahams, David Barros, Sonja Ghidelli-Disse, Klaus Fütterer, Sudagar S. Gurcha, Marcus Bantscheff, Lourdes Encinas, Ulrich Kruse, Carlos Alemparte, Stephen Bethell, Gerard Drewes, Peter J. Jervis, Lluis Ballell, Iñigo Angulo-Barturen, Nicholas Cammack, Apoorva Bhatt, Vijayashankar Nataraj, Modesto J. Remuiñán, Albel Singh, Gurdyal S. Besra
Phenotypic screens for bactericidal compounds against drug-resistant tuberculosis are beginning to yield novel inhibitors. However, reliable target identification remains challenging. Here, we show that tetrahydropyrazo[1,5-a]pyrimidine-3-carboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82ad38ad8cbf4d65682bd718d998eda
https://publications.aston.ac.uk/id/eprint/30840/1/EchA6_essential_fatty_acid_shuttle_in_mycobacteria.pdf
https://publications.aston.ac.uk/id/eprint/30840/1/EchA6_essential_fatty_acid_shuttle_in_mycobacteria.pdf
Autor:
M. Belén Cid, Modesto J. Remuiñán, Sara Duce, Jesús López-Cantarero, José L. García Ruano, José Alemán
Publikováno v:
Journal of Sulfur Chemistry. 30:370-376
2-p−Tolylsulfinyl benzyltributyltin undergoes smooth coupling conditions with allyl and alkynyl derivatives in the presence of Cu(I) salts. It demonstrates that the sluggish benzyl transfer in Stille coupling reactions mediated by copper can be sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75907f7e4abc05c1e2cab531e0aa893e
https://doi.org/10.1080/17415990902998595
https://doi.org/10.1080/17415990902998595
Autor:
Nalini Mehta, Fatima Ortega-Muro, Vickey L. Spivey, Jorge Esquivias, Iñigo Angulo-Barturen, María Teresa Fraile-Gabaldón, Carlos Alemparte, Nicholas Cammack, Douglas J. Minick, David J. Dow, Modesto J. Remuiñán, Lluis Ballell, Chrystala Constantinidou, María Martínez-Hoyos, Monica Cacho, Esther Pérez-Herrán, Elena Jimenez, María José Rebollo-López, David Barros, Nicholas J. Loman, Alfonso Mendoza-Losana, Mark J. Pallen, Joaquín Rullas, Veronica Sousa, Johnson Afari, Carolina González, Gurdyal S. Besra
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e60933 (2013)
PLoS ONE, Vol 8, Iss 4, p e60933 (2013)
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b550f1f0fde440b17ee4881449552aff
http://europepmc.org/articles/PMC3629081
http://europepmc.org/articles/PMC3629081
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1099-1102
A short and efficient synthesis of N, N, N′, N′-[2,6-bis(3-aminomethyl-1-pyrazolyl)pyridine]-tetrakis(acetic acid)(6), an analogue of terpyridine with additional chelating iminodiacetic groups, is described. Compound 6 forms stable complexes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2cf2974e6e7889d0e5b871d221060c
https://doi.org/10.1039/p29930001099
https://doi.org/10.1039/p29930001099