GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Autor: Dand N; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Health Data Research UK, London, UK., Stuart PE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Bowes J; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Nititham J; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Saklatvala JR; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Teder-Laving M; Institute of Genomics, University of Tartu, Tartu, Estonia., Thomas LF; Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Traks T; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Uebe S; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Assmann G; RUB University Hospital JWK Minden, Department of Rheumatology, Minden, Germany.; Jose-Carreras Centrum for Immuno- and Gene Therapy, University of Saarland Medical School, Homburg, Germany., Baudry D; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Behrens F; Division of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany., Billi AC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Brown MA; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Genomics England, Canary Wharf, London, UK., Burkhardt H; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Capon F; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Chung R; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Curtis CJ; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Duckworth M; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Ellinghaus E; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., FitzGerald O; UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland., Gerdes S; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Griffiths CEM; Centre for Dermatology Research, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK.; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Department of Dermatology, King's College Hospital NHS Foundation Trust, London, UK., Gulliver S; Newlab Clinical Research Inc, St. John's, NL, Canada., Helliwell P; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, UK.; Leeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds, UK., Ho P; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK.; The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Holmen OL; HUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Huang ZM; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Jadon D; Department of Medicine, University of Cambridge, Cambridge, UK., Köhm M; Division of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany., Kraus C; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Lamacchia C; Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland., Lee SH; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Ma F; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Mahil SK; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., McHugh N; Royal National Hospital for Rheumatic Diseases and Dept Pharmacy and Pharmacology, University of Bath, UK., McManus R; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland., Modalsli EH; Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Nissen MJ; Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland., Nöthen M; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Oji V; Department of Dermatology, University of Münster, Münster, Germany., Oksenberg JR; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA., Patrick MT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Perez-White BE; Department of Dermatology, Northwestern University, Evanston, IL, USA., Ramming A; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Rech J; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Rosen C; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Sarkar MK; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Schett G; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Schmidt B; Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Tejasvi T; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA., Traupe H; Department of Dermatology, University of Münster, Münster, Germany., Voorhees JJ; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Wacker EM; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Warren RB; Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK.; Centre for Dermatology Research, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M6 8HD, UK., Wasikowski R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Weidinger S; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Wen X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang Z; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Barton A; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK.; The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK., Chandran V; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Foerster J; College of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Gladman DD; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gulliver W; Newlab Clinical Research Inc, St. John's, NL, Canada.; Department of Dermatology, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Hüffmeier U; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Kingo K; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.; Dermatology Clinic, Tartu University Hospital, Tartu, Estonia., Kõks S; Perron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia., Liao W; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Løset M; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Nair RP; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Rahman P; Memorial University of Newfoundland, St. John's, NL, Canada., Reis A; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Smith CH; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., Di Meglio P; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Barker JN; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Simpson MA; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Elder JT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Oct 05. Date of Electronic Publication: 2023 Oct 05.

Assessment of a causal relationship between body mass index and atopic dermatitis.

Autor: Budu-Aggrey A; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Watkins SH; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Brumpton B; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Thoracic and Occupational Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Løset M; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Dermatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Tyrrell J; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom., Modalsli EH; Department of Dermatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Vie GÅ; Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Palmer T; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Fritsche LG; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Nielsen JB; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Mich., Romundstad PR; Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Davey Smith G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Endocrinology, St Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Paternoster L; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Brown SJ; Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom. Electronic address: s.j.brown@dundee.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jan; Vol. 147 (1), pp. 400-403. Date of Electronic Publication: 2020 May 17.

Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study.

Autor: Snekvik I; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Norway; Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway. Electronic address: ingrid.snekvik@ntnu.no., Smith CH; St. John's Institute of Dermatology, Division of Medicine and Molecular Genetics, Guy's Hospital, London, UK., Nilsen TIL; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Norway., Langan SM; London School of Hygiene and Tropical Medicine, Keppel Street, London, UK., Modalsli EH; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Norway; Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway., Romundstad PR; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Norway., Saunes M; Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway; Department of Cancer Research and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2017 Dec; Vol. 137 (12), pp. 2484-2490. Date of Electronic Publication: 2017 Aug 02.

Psoriasis, fracture risk and bone mineral density: the HUNT Study, Norway.

Autor: Modalsli EH; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway., Åsvold BO; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Norway., Romundstad PR; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Langhammer A; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hoff M; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Rheumatology, St. Olavs Hospital, Trondheim University Hospital, Norway.; Nord-Trøndelag Hospital Trust, Levanger, Norway., Forsmo S; Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Naldi L; Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED), Bergamo, Italy.; Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy., Saunes M; Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Norway.; Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Publikováno v: The British journal of dermatology [Br J Dermatol] 2017 May; Vol. 176 (5), pp. 1162-1169. Date of Electronic Publication: 2017 Mar 15.