Výsledky vyhledávání - "Modachur G. Murugesh"

A New Method for Installation of Aryl and Alkenyl Groups onto a Cyclopentene Ring and Synthesis of Prostaglandins

Autor: Yuichi Kobayashi, Eisuke Takahisa, Miwa Nakano, Takayuki Ainai, Shahid B. Usmani, Modachur G. Murugesh

Publikováno v: J. Org. Chem.. 67(No. 20):7110-7123

To construct a new strategy for synthesis of cyclopentanoids, the transition metal-catalyzed coupling reaction of cis 4-cyclopentene-1,3-diol monoacetate 1 with hard nucleophiles, R(T)-m, was investigated (eq 1 in Chart 1). Although preliminary exper

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http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100472820

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Scope and Limitation of Organocuprates, and Copper or Nickel Catalyst-Modified Grignard Reagents for Installation of an Alkyl Group onto cis-4-Cyclopentene-1,3-diol Monoacetate

Autor: Michiko Ito, Michitaka Matsuumi, Modachur G. Murugesh, Yuichi Kobayashi

Publikováno v: The Journal of Organic Chemistry. 66:5881-5889

Alkylation of the title compound 1 was investigated with two types of reagents. One is a copper reagent derived from R(T)MgX (X = Cl, Br) and CuX (X = CN, I) and the other is R(T)MgX in the presence of a copper or a nickel catalyst. First, butylation

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https://doi.org/10.1021/jo010474w

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Synthesis of Δ7-prostaglandin A1 methyl ester

Autor: Yuichi Kobayashi, Modachur G. Murugesh, Miwa Nakano

Publikováno v: Tetrahedron Letters. 42:1703-1707

Aldol reaction at the α′ position of 4-alkenyl cyclopentenone was investigated briefly in order to develop a synthesis of the target molecule. The efficient reaction conditions we found (LDA at −78°C in THF) were applied to the reaction between

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https://doi.org/10.1016/s0040-4039(00)02329-7

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Regio- and Stereoselective Installation of Alkyl Groups onto cis 4-Cyclopentene-1,3-diol Monoacetate by using Reagents derived from Alkylmagnesium Halides

Autor: Modachur G. Murugesh, Yuichi Kobayashi, Michiko Ito

Publikováno v: Tetrahedron Lett.. 42:423-427

Reaction of cis 4-cyclopentene-1,3-diol monoacetate with alkyl reagents derived from RMgX and CuCN furnished either trans 4-alkyl-2-cyclopenten-1-ols (1,4-isomers) or trans 2-alkyl-3-cyclopenten-1-ols (1,2-isomers) depending upon the stoichiometry of

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http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100444129

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Design, synthesis and evaluation of carbamate-modified (−)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Autor: Tetsuhiro Niidome, Modachur G. Murugesh, Ichiro Hijikuro, Takashi Takahashi, Yoshinori Tsumura, Hachiro Sugimoto, Takeshi Kihara, Akinori Akaike, Shinichiro Fuse, Jun Takahashi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:1721-1723

We synthesized carbamate-modified (−)-N1-phenethylnorphysostigmine derivatives 3a–u and evaluated their anti-cholinesterase activities. In vitro evaluation showed that cyclohexylmethylcarbamate derivative 3u potently and selectively inhibits buty

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https://doi.org/10.1016/j.bmcl.2010.01.035

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Design, synthesis, evaluation and QSAR analysis of N1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Autor: Hachiro Sugimoto, Ryo Kunimoto, Tetsuhiro Niidome, Takeshi Kihara, Akinori Akaike, Yoshinori Tsumura, Jun Takahashi, Modachur G. Murugesh, Yasushi Okuno, Ichiro Hijikuro, Takashi Takahashi, Shinichiro Fuse

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:1718-1720

We synthesized a series of N 1 -substituted norcymserine derivatives 7a – p and evaluated their anti-cholinesterase activities. In vitro evaluation showed that the pyridinylethyl derivatives 7m – o and the piperidinylethyl derivative 7p improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db32f5af5197966afcc1d871e42a853
https://doi.org/10.1016/j.bmcl.2010.01.057

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Regioselective total synthesis of (±) Neorautane, (±) Neorautanin and their analogs. Microwave mediated synthesis of 2H-chromenes from propargyl phenyl ethers

Autor: Modachur G. Murugesh, Girish K. Trivedi, Kandasamy Subburaj, Rita Katoch

Publikováno v: Tetrahedron. 53:12621-12628

Herein we describe the total synthesis of (+/-) Neorautane 1. (+/-) Neorautanin 2 and their analogs 15-18. The key intermediates Chromenes 10-13 were synthesised by microwave irradiation of propargyl phenyl ethers 8 and 9 in DMF under pressure. (C) 1

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https://doi.org/10.1016/s0040-4020(97)00783-7

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ChemInform Abstract: Scope and Limitation of Organocuprates, and Copper or Nickel Catalyst-Modified Grignard Reagents for Installation of an Alkyl Group onto cis-4-Cyclopentene-1,3-diol Monoacetate

Autor: Yuichi Kobayashi, Modachur G. Murugesh, Michitaka Matsuumi, Michiko Ito

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5911e8de5d1716a6ff4c4bf1db15626
https://doi.org/10.1002/chin.200204091

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