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Complete Combinatorial Mutational Enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity.

Autor: Colom MS; Institute for Protein Innovation; Boston, Massachusetts, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA.; current address: AI Proteins; Boston, Massachusetts, 02215, USA., Vucinic J; Université Fédérale de Toulouse; ANITI, IRIT-CNRS UMR 5505, Université Toulouse Capitole, 31000 Toulouse, France., Adolf-Bryfogle J; Institute for Protein Innovation; Boston, Massachusetts, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA., Bowman JW; Institute for Protein Innovation; Boston, Massachusetts, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA.; current address: AI Proteins; Boston, Massachusetts, 02215, USA., Verel S; Université Littoral Côte d'Opale; UR 4491, LISIC, F-62100 Calais, France., Moczygemba I; Institute for Protein Innovation; Boston, Massachusetts, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA.; current address: AI Proteins; Boston, Massachusetts, 02215, USA., Schiex T; Université Fédérale de Toulouse; ANITI, INRAE-UR 875, 31000 Toulouse, France., Simoncini D; Université Fédérale de Toulouse; ANITI, IRIT-CNRS UMR 5505, Université Toulouse Capitole, 31000 Toulouse, France., Bahl CD; Institute for Protein Innovation; Boston, Massachusetts, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA.; current address: AI Proteins; Boston, Massachusetts, 02215, USA.

Publikováno v: Research square [Res Sq] 2023 Sep 11. Date of Electronic Publication: 2023 Sep 11.