Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.

Autor: Lesuis SL; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Cellular and Computational Neuroscience, Swammerdam Institute for Life Science, Amsterdam Neuroscience, University of Amsterdam, 1090 GE Amsterdam, the Netherlands., Park S; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Hoorn A; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Rashid AJ; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Mocle AJ; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Salter EW; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and TANZ Centre for Research in Neurodegenerative Diseases, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Vislavski S; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Gray MT; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Torelli AM; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., DeCristofaro A; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Driever WPF; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University and Oncode Institute, Einsteinweg 55, Leiden 2333 CC, the Netherlands., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University and Oncode Institute, Einsteinweg 55, Leiden 2333 CC, the Netherlands., Zweifel LS; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, 2815 Eastlake Ave E Suite 200, Seattle, WA 98102, USA., Collingridge GL; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and TANZ Centre for Research in Neurodegenerative Diseases, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Lefebvre JL; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Walters BJ; Department of Cell and Systems Biology, University of Toronto Mississauga, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada., Frankland PW; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: paul.frankland@sickkids.ca., Hill MN; Hotchkiss Brain Institute, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada. Electronic address: mnhill@ucalgary.ca., Josselyn SA; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: sheena.josselyn@sickkids.ca.

Publikováno v: Cell [Cell] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.

Dentate gyrus ensembles gate context-dependent neural states and memory retrieval.

Autor: Coelho CAO; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada., Mocle AJ; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Jacob AD; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada., Ramsaran AI; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada., Rashid AJ; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada., Köhler S; Department of Psychology, University of Western Ontario, London, ON, Canada., Josselyn SA; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Frankland PW; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Child & Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON, Canada.

Publikováno v: Science advances [Sci Adv] 2024 Aug 02; Vol. 10 (31), pp. eadn9815. Date of Electronic Publication: 2024 Aug 02.

Examining the engram encoding specificity hypothesis in mice.

Autor: Jung JH; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Wang Y; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Mocle AJ; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Zhang T; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada., Köhler S; Department of Psychology, University of Western Ontario, London, ON N6A 5C2, Canada; The Brain and Mind Institute, University of Western Ontario, London, ON N6A 3K7, Canada., Frankland PW; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Child & Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada., Josselyn SA; Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada. Electronic address: sheena.josselyn@sickkids.ca.

Publikováno v: Neuron [Neuron] 2023 Jun 07; Vol. 111 (11), pp. 1830-1845.e5. Date of Electronic Publication: 2023 Mar 28.

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice.

Autor: Steadman PE; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada., Xia F; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada., Ahmed M; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada., Mocle AJ; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada., Penning ARA; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada., Geraghty AC; Department of Neurology, Stanford University, Stanford, CA 94305, USA., Steenland HW; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Max Planck Institute of Microstructure Physics, Halle 06120, Germany., Monje M; Department of Neurology, Stanford University, Stanford, CA 94305, USA., Josselyn SA; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Brain, Mind and Consciousness Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada., Frankland PW; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada. Electronic address: paul.frankland@sickkids.ca.

Publikováno v: Neuron [Neuron] 2020 Jan 08; Vol. 105 (1), pp. 150-164.e6. Date of Electronic Publication: 2019 Nov 18.

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

Autor: Maiuri T; Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5., Mocle AJ; Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5., Hung CL; Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5., Xia J; Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5., van Roon-Mom WM; Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-0P, P.O. Box 9600 2300RC Leiden, The Netherlands., Truant R; Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Jan 15; Vol. 26 (2), pp. 395-406.