Výsledky vyhledávání

Bifunctional PD-1 x alpha CD3 x alpha CD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia

Autor: Hermann, M., Krupka, C., Deiser, K., Brauchle, B., Marcinek, A., Ogrinc Wagner, A., Rataj, F., Mocikat, R., Metzeler, K.H., Spiekermann, K., Kobold, S., Fenn, N.C., Hopfner, K.P., Subklewe, M.

Publikováno v: Blood 132, 2484-2494 (2018)

The CD33-targeting bispecific T-cell engager (BiTE) AMG 330 proved to be highly efficient in mediating cytolysis of acute myeloid leukemia (AML) cells in vitro and in mouse models. Yet, T-cell activation is correlated with upregulation of programmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3474::c53c0399715cf783c0483f1a1f24b1cf
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=54444

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Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies

Autor: Pötzl, J., Roser, D., Bankel, L., Hömberg, N., Geishauser, A., Brenner, C.D., Weigand, M.A., Röcken, M., Mocikat, R.

Publikováno v: Int. J. Cancer 140, 2125-2133 (2017)

Like other immune cells, natural killer (NK) cells show impaired effector functions in the microenvironment of tumors, but little is known on the underlying mechanisms. Since lactate acidosis, a hallmark of malignant tissue, was shown to contribute t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::78d3a1aa0a1e4fe502e598e283145349
https://pubmed.ncbi.nlm.nih.gov/28195314

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Akademický článek

Unaltered immunoglobulin expression in hybridoma cells modified by targeting of the heavy chain locus with an integration vector.

Autor: Mocikat, R.¹, Kardinal, C.¹, Lang, P.¹, Zeidler, R.², Thierfelder, S.¹

Publikováno v: Immunology. Jan1995, Vol. 84 Issue 1, p159-163. 5p.

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Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma

Autor: Belting, L., Hömberg, N., Przewoznik, M., Brenner, C., Riedel, T., Flatley, A., Polić, Bojan, Busch, DH., Röcken, M., Mocikat, R.

Publikováno v: Eur. J. Immunol. 45, 2593-2601 (2015)

Little is known on the control of lymphomas by NK cells. Here, we study the role of the NK group 2D (NKG2D) receptor for the immunosurveillance of lymphoma. By using transplantable tumors as well as a λ-myc-transgenic model of endogenously arising l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::363141b57d9c085469aa3c86ac520eec
https://pubmed.ncbi.nlm.nih.gov/26151313

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Genetic stability of gene-targeted immunoglobulin loci. II. Influence of the cell line and the vector linearization site

Autor: M Selmayr, C Kardinal, Mocikat R

Publikováno v: Molecular and General Genetics MGG. 256:499-508

The site-specific integration of exogenous gene fragments by homologous recombination provides a convenient method for altering the immunoglobulin loci of B cells and specifically designing antibody molecules. To introduce a human isotype into the he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120062ff29378f6ac5f908cfe0dfff1f
https://doi.org/10.1007/s004380050594

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DC-NK cell cross talk as a novel CD4⁺ T-cell-independent pathway for antitumor CTL induction

Autor: Adam, C., King, S., Allgeier, T., Braumüller, H., Lüking, C., Mysliwietz, J., Kriegeskorte, A.K., Busch, D.H., Röcken, M., Mocikat, R.

Publikováno v: Blood 106, 338-344 (2005)

It is generally accepted that priming of antitumor CD8 cytotoxic T lymphocytes (CTLs) needs help that can be provided by CD4 T cells. We show that interactions between dendritic cells (DCs) and natural killer (NK) cells can bypass the T helper arm in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3474::e83ba3ce5407af6793f51ba81f642bed
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=666

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Akademický článek

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Eradication of Disseminated Lymphomas with CpG-DNA Activated T Helper Type Cells from Nontransgenic Mice

Autor: Egeter, O., Mocikat, R., Ghoreschi, K., Dieckmann, A., Röcken, M.

Publikováno v: Cancer Res. 60, 1515-1520 (2000)

Various evidence suggests that adoptive transfer of polyclonal, tumor-specific, IFN-γ-producing CD4+ T cells [T helper type 1 (Th1) cells] should be highly efficient for tumor immune therapy. However, this approach could not be tested because very f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3474::b750a04b0186c4b12eb36a8e4bfef0f8
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=21357

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