Anti-tumor Effect of Rhaponticum uniflorum Ethyl Acetate Extract by Regulation of Peroxiredoxin1 and Epithelial-to-Mesenchymal Transition in Oral Cancer

Autor: Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects.Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA)

Externí odkaz: https://doaj.org/article/1d0f80ec908a49ec925227b478b2cc5e

Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins

Autor: Min Wang, Jing Yang, Lingyu Li, Xiaofei Tang, Moci Qi, Min Zhang, Yunping Lu

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 54, Iss 9 (2021)
Brazilian Journal of Medical and Biological Research v.54 n.9 2021
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

Tobacco can induce reactive oxygen species (ROS) production extensively in cells, which is a major risk factor for oral leukoplakia (OLK) development. Peroxiredoxin 1 (Prx1) is a key antioxidant protein, upregulated in a variety of malignant tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de04c38398baa798258ac2eb4e451aef
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000900605&tlng=en

Proteome profiling to identify peroxiredoxin 1 interacting protein partners in nicotine-associated oral leukoplakia

Autor: Jing Yang, Xiaofei Tang, Lingyu Li, Lihua Ge, Min Wang, Ni Shi, Tong Chen, Moci Qi, Min Zhang, Hui Chen, Yunping Lu

Publikováno v: Archives of Oral Biology. 108:104537

Objective Tobacco smoking is one of the main risk factors for oral squamous cell carcinoma (OSCC) and can induce generation of reactive oxygen species (ROS). In our previous studies, we demonstrated that nicotine, the major ingredient in tobacco, can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21325c6c32e734e482b7eeed98701976
https://doi.org/10.1016/j.archoralbio.2019.104537

Abstract A51: Nicotine induces cervical lymph node metastasis of mouse tongue cancer by regulating Prx1 /EMT signaling

Autor: Min Wang, Xiaofei Tang, Wenwen Niu, Moci Qi

Publikováno v: Cancer Research. 78:A51-A51

Oral squamous cell carcinoma (OSCC) represents one of the most common malignant neoplasms worldwide, while tobacco is a major risk factor for OSCC. Nicotine has been reported to induce EMT and promote the progression in several malignant tumors. Our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7997e64ccad4bb04aeb2d830c63def5
https://doi.org/10.1158/1538-7445.mousemodels17-a51