Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mochizuki, Michiyo"'
Autor:
Kojima, Takuto, Mochizuki, Michiyo, Takai, Takafumi, Hoashi, Yasutaka, Morimoto, Sachie, Seto, Masaki, Nakamura, Minoru, Kobayashi, Katsumi, Sako, Yuu, Tanaka, Maiko, Kanzaki, Naoyuki, Kosugi, Yohei, Yano, Takahiko, Aso, Kazuyoshi
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 May 2018 26(9):2229-2250
Autor:
Mochizuki, Michiyo, Kojima, Takuto, Kobayashi, Katsumi, Kotani, Etsuo, Ishichi, Yuji, Kanzaki, Naoyuki, Nakagawa, Hideyuki, Okuda, Teruaki, Kosugi, Yohei, Yano, Takahiko, Sako, Yuu, Tanaka, Maiko, Aso, Kazuyoshi
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 March 2017 25(5):1556-1570
Autor:
Mochizuki, Michiyo, Kori, Masakuni, Kono, Mitsunori, Yano, Takahiko, Sako, Yuu, Tanaka, Maiko, Kanzaki, Naoyuki, Gyorkos, Albert C., Corrette, Christopher P., Aso, Kazuyoshi
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 October 2016 24(19):4675-4691
Autor:
Etsuo Kotani, Kazuyoshi Aso, Yohei Kosugi, Mochizuki Michiyo, Takuto Kojima, Takahiko Yano, Maiko Tanaka, Teruaki Okuda, Yuu Sako, Hideyuki Nakagawa, Yuji Ishichi, Naoyuki Kanzaki, Katsumi Kobayashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1556-1570
Compound 1 exhibits potent binding inhibition activity against a corticotropin-releasing factor 1 (CRF1) receptor (IC50=9.5nM) and in vitro antagonistic activity (IC50=88nM) but is rapidly metabolized by human hepatic microsomes (182μL/min/mg). Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049814ad68ed4e97ee9152f6e5cc7752
https://doi.org/10.1016/j.bmc.2016.11.011
https://doi.org/10.1016/j.bmc.2016.11.011
Autor:
Scott Alan Pratt, Kazuyoshi Aso, Albert Charles Gyorkos, Suk Young Cho, Christopher Peter Corrette, Katsumi Kobayashi, Masakuni Kori, Naoyuki Kanzaki, Maiko Tanaka, Mochizuki Michiyo, Yuu Sako, Takahiko Yano
Publikováno v:
Journal of Medicinal Chemistry. 59:2551-2566
Benzazole derivatives with a flexible aryl group bonded through a one-atom linker as a new scaffold for a corticotropin-releasing factor 1 (CRF1) receptor antagonist were designed, synthesized, and evaluated. We expected that structural diversity cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508c973ae7e4bfaa3ec6e498fe1e44e
https://doi.org/10.1021/acs.jmedchem.5b01715
https://doi.org/10.1021/acs.jmedchem.5b01715
Autor:
Minoru Nakamura, Takuto Kojima, Kazuyoshi Aso, Sachie Morimoto, Katsumi Kobayashi, Naoyuki Kanzaki, Takahiko Yano, Yohei Kosugi, Mochizuki Michiyo, Yasutaka Hoashi, Takafumi Takai, Masaki Seto, Maiko Tanaka, Yuu Sako
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
A new class of corticotropin releasing factor 1 (CRF1) receptor antagonists characterized by a tricyclic core ring was designed and synthesized. Novel tricyclic derivatives 2a–e were designed as CRF1 receptor antagonists based on conformation analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edef56b45fc31edad5afc254d960aa3b
https://pubmed.ncbi.nlm.nih.gov/29459145
https://pubmed.ncbi.nlm.nih.gov/29459145
Autor:
Yuu Sako, Masakuni Kori, Mitsunori Kono, Naoyuki Kanzaki, Takahiko Yano, Kazuyoshi Aso, Maiko Tanaka, Albert Charles Gyorkos, Mochizuki Michiyo, Christopher Peter Corrette
Publikováno v:
Bioorganicmedicinal chemistry. 24(19)
A promising lead compound 1 of a benzimidazole series has been identified as a corticotropin-releasing factor 1 (CRF1) receptor antagonist. In this study, we focused on replacement of a 7-alkylamino group of 1, predicted to occupy a large lipophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a5e071b723ffe65e3ee4615535eff
https://pubmed.ncbi.nlm.nih.gov/27567079
https://pubmed.ncbi.nlm.nih.gov/27567079
Akademický článek
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Autor:
Aso, Kazuyoshi, Kobayashi, Katsumi, Mochizuki, Michiyo, Kanzaki, Naoyuki, Sako, Yuu, Yano, Takahiko
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2011 21(8):2365-2371
Autor:
Carideo Cunniff E; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Sato Y; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Mai D; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Appleman VA; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Iwasaki S; Takeda Pharmaceutical Company, Ltd., Fujisawa, Kanagawa, Japan., Kolev V; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Matsuda A; Takeda Pharmaceutical Company, Ltd., Fujisawa, Kanagawa, Japan., Shi J; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Mochizuki M; Takeda Pharmaceutical Company, Ltd., Fujisawa, Kanagawa, Japan., Yoshikawa M; Takeda Pharmaceutical Company, Ltd., Fujisawa, Kanagawa, Japan., Huang J; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Shen L; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Haridas S; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Shinde V; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Gemski C; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Roberts ER; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Ghasemi O; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Bazzazi H; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Menon S; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Traore T; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Shi P; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Thelen TD; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Conlon J; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Abu-Yousif AO; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Arendt C; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Shaw MH; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts., Okaniwa M; Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts.
Publikováno v:
Cancer research communications [Cancer Res Commun] 2022 Jun 23; Vol. 2 (6), pp. 489-502. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).