Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Moana Tercel"'
Autor:
Tet Woo Lee, Dean C. Singleton, Julia K. Harms, Man Lu, Sarah P. McManaway, Amy Lai, Moana Tercel, Frederik B. Pruijn, Andrew M. J. Macann, Francis W. Hunter, William R. Wilson, Stephen M. F. Jamieson
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1885-1903 (2024)
Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model
Externí odkaz:
https://doaj.org/article/8463ca23a4994262a7d8bf8b809ac374
Autor:
Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential
Externí odkaz:
https://doaj.org/article/84cc219bd1d44edcb71e6c37eef0a1bb
Autor:
Peter Jaein Choi, Petr Tomek, Moana Tercel, Jóhannes Reynisson, Thomas In Hyeup Park, Elizabeth Alexandra Cooper, William Alexander Denny, Jiney Jose, Euphemia Leung
Publikováno v:
Molecules, Vol 27, Iss 3, p 880 (2022)
The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in
Externí odkaz:
https://doaj.org/article/e671aec5e09f4bc3b420e8a46419a8b3
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Supplementary Data from Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1a13337fc2c96e19e47692ba0a48b4
https://doi.org/10.1158/1535-7163.22482483.v1
https://doi.org/10.1158/1535-7163.22482483.v1
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Hypoxia represents an important therapeutic target in tumors because of the resistance of hypoxic cells to radiotherapy and chemotherapy and because it is more severe in many tumors than in normal tissues. Here, we describe a class of prodrugs, nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714841c611cd9afe078394aa781cbc2d
https://doi.org/10.1158/1535-7163.c.6530940.v1
https://doi.org/10.1158/1535-7163.c.6530940.v1
Autor:
William R. Wilson, Moana Tercel, Kevin O. Hicks, Frederik B. Pruijn, Sunali Mehta, Sarah P. McManaway, H. D. Sarath Liyanage, Cho R. Hong, Gib Bogle, Jagdish K. Jaiswal, Ho H. Lee
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:673-687
Hypoxia-activated prodrugs (HAPs) have the potential for eliminating chemo- and radiation-resistant hypoxic tumour cells, but their activity is often compromised by limited penetration into hypoxic zones. Nitrochloromethylbenzindoline (nitroCBI) HAPs
Publikováno v:
Tetrahedron. 75:3001-3007
An optimised synthesis of a hypoxia-activated anticancer prodrug related to the duocarmycin family of natural products is described. The improved 10-step synthesis increases the overall yield from 4.4% to over 40% while requiring just 2 chromatograph
Autor:
Euphemia Leung, Peter J. Choi, Thomas I. H. Park, William A. Denny, Jiney Jose, Jóhannes Reynisson, Petr Tomek, Moana Tercel, Elizabeth Cooper
Publikováno v:
Molecules; Volume 27; Issue 3; Pages: 880
Molecules, Vol 27, Iss 880, p 880 (2022)
Molecules, Vol 27, Iss 880, p 880 (2022)
The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in
Autor:
Ho H. Lee, Sunali Mehta, H. D. Sarath Liyanage, Sally Y. Bai, Frederik B. Pruijn, Moana Tercel, Jean-Jacques Youte Tendoung
Publikováno v:
Journal of Medicinal Chemistry. 60:5834-5856
A new series of nitro analogues of the duocarmycins was prepared and evaluated for hypoxia-selective anticancer activity. The compounds incorporate 13 different amine-containing side chains designed to bind in the minor groove of DNA while spanning a
Autor:
Ho H. Lee, Jun Guo, Anna C. Giddens, Thomas H. Pillow, Christian K. Miller, Moana Tercel, Guo-Liang Lu, Gail Lewis Phillips
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:6075-6081
A Pd-catalysed amination method is used to convert seco-CBI, a synthetic analogue of the alkylating subunit of the duocarmycin natural products, from the phenol to amino form. This allows efficient enantioselective access to the more potent S enantio