Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

Autor: Moakes Catherine A, Tong Stephen, Middleton Lee J, Duncan W Colin, Mol Ben W, Whitaker Lucy H R, Jurkovic Davor, Coomarasamy Arri, Nunes Natalie, Holland Tom, Clarke Fiona, Sutherland Lauren C, Doust Ann M, Daniels Jane P, Horne Andrew W

Publikováno v: Efficacy and Mechanism Evaluation, Vol 10, Iss 01 (2023)

Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women. Gefitinib, an epidermal growth factor recep

Externí odkaz: https://doaj.org/article/7d03bbd52580498aa201def74ae60531

Determining optimal timing of birth for women with chronic or gestational hypertension at term: The WILL (When to Induce Labour to Limit risk in pregnancy hypertension) randomised trial.

Autor: Magee LA; Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.; Institute of Women and Children's Health, King's College London, London, United Kingdom., Kirkham K; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Tohill S; Maternity Services, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Gkini E; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Moakes CA; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Dorling J; Department of Paediatrics, University of Southampton, Southampton, United Kingdom., Green M; Action on Pre-Eclampsia (APEC), Evesham, United Kingdom., Hutcheon JA; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada., Javed M; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Kigozi J; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Mol BWM; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia., Singer J; School of Population and Public Health and Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, Canada., Hardy P; National Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, United Kingdom., Stubbs C; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Thornton JG; Department of Obstetrics and Gynaecology, University of Nottingham, Nottingham, United Kingdom., von Dadelszen P; Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.; Institute of Women and Children's Health, King's College London, London, United Kingdom.

Publikováno v: PLoS medicine [PLoS Med] 2024 Nov 26; Vol. 21 (11), pp. e1004481. Date of Electronic Publication: 2024 Nov 26 (Print Publication: 2024).

Cerclage suture type to prevent pregnancy loss in women requiring a vaginal cervical cerclage: the C-STICH RCT.

Autor: Hodgetts Morton V; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.; Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, UK., Moakes CA; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Daniels J; Department of Obstetrics and Gynaecology, Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK., Middleton L; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Shennan A; Department of Obstetrics and Gynaecology, Guy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK., Brocklehurst P; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Israfil-Bayli F; Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, UK., Ewer AK; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Gray J; Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, UK., Simpson NA; Department of Obstetrics and Gynaecology, University of Leeds, Leeds, UK., Norman JE; University of Bristol, Bristol, UK., Lees C; Department of Obstetrics and Gynaecology, Imperial College London, London, UK., Tryposkiadis K; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Stubbs C; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Hughes M; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK., Morris RK; Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.; Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, UK., Toozs-Hobson P; Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, UK.

Publikováno v: Health technology assessment (Winchester, England) [Health Technol Assess] 2024 Aug; Vol. 28 (40), pp. 1-44.

Editor's Choice - Bypass versus Angioplasty for Severe Ischaemia of the Leg (BASIL) Prospective Cohort Study and the Generalisability of the BASIL-2 Randomised Controlled Trial.

Autor: Popplewell MA; Institute of Applied Health Research, University of Birmingham, Birmingham, UK. Electronic address: m.a.popplewell@bham.ac.uk., Meecham L; University Hospital of Wales, Cardiff, UK., Davies HOB; University Hospital of Wales, Cardiff, UK., Kelly L; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Ellis T; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Bate GR; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Moakes CA; Birmingham Clinical Trial Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Bradbury AW; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Publikováno v: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2024 Jan; Vol. 67 (1), pp. 146-152. Date of Electronic Publication: 2023 Sep 30.

Subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate.

Autor: Mackenzie SC; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK., Moakes CA; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK., Duncan WC; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK., Tong S; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia., Horne AW; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.

Publikováno v: Reproduction & fertility [Reprod Fertil] 2023 Jun 15; Vol. 4 (2). Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).