Zobrazeno 1 - 10
of 496
pro vyhledávání: '"Moacir, Wajner"'
Autor:
Josyane de Andrade Silveira, Manuela Bianchin Marcuzzo, Jaqueline Santana da Rosa, Nathalia Simon Kist, Chrístofer Ian Hernandez Hoffmann, Andrey Soares Carvalho, Rafael Teixeira Ribeiro, André Quincozes-Santos, Carlos Alexandre Netto, Moacir Wajner, Guilhian Leipnitz
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1563 (2024)
3-Hydroxy-3-methylglutaric acidemia (HMGA) is a neurometabolic inherited disorder characterized by the predominant accumulation of 3-hydroxy-3-methylglutaric acid (HMG) in the brain and biological fluids of patients. Symptoms often appear in the firs
Externí odkaz:
https://doaj.org/article/4ffe427a0be546ca9c5764d07b9f144f
Autor:
Adriana Fernanda K. Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalves
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-23 (2022)
Highlights LPS-induced neuroinflammation promotes metabolic reprogramming. Neuroinflammation increased glycolytic flow and lactate release. Inhibitors of different glycolytic reactions prevented the inflammatory response. S100B changes suggest a role
Externí odkaz:
https://doaj.org/article/72847adb73c4423881e214e0bf2eb293
Publikováno v:
Clinical and Biomedical Research, Vol 21, Iss 3 (2022)
Os erros inatos do metabolismo são doenças metabólicas hereditárias individualmente raras, mas que em seu conjunto apresentam uma incidência aproximada de pelo menos 1 caso para cada mil nascimentos. O presente trabalho teve por objetivos descre
Externí odkaz:
https://doaj.org/article/252159659bb3421b85e407e5d0fd3a3b
Autor:
Janice C. Coelho, Maira G. Burin, Moacir Wajner, Carmem R. Vargas, Fernanda T. S. Souza, Roberto Giugliani
Publikováno v:
Clinical and Biomedical Research, Vol 21, Iss 3 (2022)
OBJETIVOS: O número de erros inatos do metabolismo (EIM) diagnosticados está crescendo constantemente devido ao aperfeiçoamento e disponibilidade das técnicas laboratoriais. Em 1982, foi estabelecido em Porto Alegre, Brasil, um laboratório para
Externí odkaz:
https://doaj.org/article/a594a226811b4ba8ba09736d3599e83e
Autor:
Moacir Wajner, Roberto Giugliani
Publikováno v:
Clinical and Biomedical Research, Vol 21, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/7c69bbe94fd94b988ef34f628ca5ec1b
Autor:
Morgana Brondani, Ana Cristina Roginski, Rafael Teixeira Ribeiro, Maria Paula de Medeiros, Chrístofer Ian Hernandez Hoffmann, Moacir Wajner, Guilhian Leipnitz, Bianca Seminotti
Publikováno v:
Toxicology Letters. 381:48-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a5588b99143a82343a8dbf4ec4c7e3a
https://doi.org/10.1016/j.toxlet.2023.04.011
https://doi.org/10.1016/j.toxlet.2023.04.011
Autor:
Rafael Teixeira Ribeiro, Ana Cristina Roginski, Rafael Aguiar Marschner, Simone Magagnin Wajner, Roger Frigério Castilho, Alexandre Umpierrez Amaral, Moacir Wajner
Publikováno v:
Biochimie. 207:153-164
Accumulation of D-2-hydroxyglutaric acid (D-2-HG) is the biochemical hallmark of D-2-hydroxyglutaric aciduria type I and, particularly, of D-2-hydroxyglutaric aciduria type II (D2HGA2). D2HGA2 is a metabolic inherited disease caused by gain-of-functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7954ba0b62f3e330e7608f37a66e1597
https://doi.org/10.1016/j.biochi.2022.11.004
https://doi.org/10.1016/j.biochi.2022.11.004
Autor:
Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajner
Publikováno v:
Neurotoxicity Research. 41:119-140
L-2-Hydroxyglutaric aciduria (L-2-HGA) is an inherited neurometabolic disorder caused by deficient activity of L-2-hydroxyglutarate dehydrogenase. L-2-Hydroxyglutaric acid (L-2-HG) accumulation in the brain and biological fluids is the biochemical ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6aa9a22db150c61cad166d6f638941d
https://doi.org/10.1007/s12640-022-00625-0
https://doi.org/10.1007/s12640-022-00625-0
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Deficiencies of medium-chain acyl-CoA dehydrogenase, mitochondrial trifunctional protein, isolated long-chain 3-hydroxyacyl-CoA dehydrogenase, and very long-chain acyl-CoA dehydrogenase activities are considered the most frequent fatty acid oxidation
Externí odkaz:
https://doaj.org/article/f31907d281a5419a90f1ff97504082a5
Autor:
Carmen R Vargas, Marion Deon, Angela Sitta, Daniella M Coelho, Patricia D Silva, Larissa Murussi, Laura V Fleith, Carolina Crespo, Moacir Wajner, Maria Teresa V Sanseverino
Publikováno v:
Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 56 (2020)
ABSTRACT Female patient carrier of medium-chain acyl-CoA dehydrogenase deficiency (MCADD) with recurrent clinical episodes of hypoglycemia and altered level of consciousness, presented changes in blood acylcarnitine profile by tandem mass spectrometr
Externí odkaz:
https://doaj.org/article/c9665c6483064fb6833ac07cef77cea6