Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans

Autor: Björn Andersson, Rickard Sandberg, Simone Picelli, Margherita Zamboni, Jakob Michaëlsson, Johan K. Sandberg, Laurent Modolo, Björn Reinius, Jonas Frisén, Moa Stenudd, Kim Blom, Anton J. M. Larsson, Jeff E. Mold, Carl-Johan Eriksson, Ghislain Durif, Franck Picard, Joanna Hård, Carlos Talavera-López, Pedro Réu, Erik Borgström, Patrik L. Ståhl

Publikováno v: Cell Reports
Cell Reports, 2021, 35 (8), pp.109174. ⟨10.1016/j.celrep.2021.109174⟩
Cell Reports, Elsevier Inc, 2021, 35 (8), pp.109174. ⟨10.1016/j.celrep.2021.109174⟩

International audience; The CD8+ T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells. How individual T cell clones contribute to this h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb8ce57030c63c4ec889d3a7af7a04e
https://hal.science/hal-03345357

A latent lineage potential in resident neural stem cells enables spinal cord repair

Autor: Moa Stenudd, Margherita Zamboni, Jonas Frisén, Joseph Bergenstråhle, Oleg Shupliakov, Marie Carlén, Yicheng Wu, Joakim Lundeberg, Pierre Le Merre, James M. Chell, Enric Llorens-Bobadilla, Elena Sopova

Publikováno v: Science. 370

Spinal cord stem cells Injuries to the mammalian spinal cord do not heal easily. Llorens- Bobadilla et al. studied mouse ependymal cells, which function as stem cells for the spinal cord (see the Perspective by Becker and Becker). Chromatin accessibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea7c5613122df6c4da60614f039b658
https://doi.org/10.1126/science.abb8795

Divergent Clonal Differentiation Trajectories Establish CD8 + Memory T Cell Heterogeneity During Acute Viral Infections in Humans

Autor: Anton J. M. Larsson, Carl-Johan Eriksson, Björn Reinius, Johan K. Sandberg, Carlos Talavera-López, Patrik L. Ståhl, Moa Stenudd, Ghislain Durif, Björn Andersson, Simone Picelli, Jakob Michaëlsson, Joanna Hård, Rickard Sandberg, Kim Blom, Laurent Modolo, Margherita Zamboni, Jonas Frisén, Jeff E. Mold, Erik Borgström, Franck Picard, Pedro Réu

Publikováno v: SSRN Electronic Journal.

CD8+ T cells play essential roles in immunity to viral and bacterial infections, and to guard against malignant cells. The CD8+ T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d868884fa3f6938de53982904967c38f
https://doi.org/10.2139/ssrn.3606766

Neural stem cells in the adult spinal cord

Autor: Moa Stenudd, Hanna Sabelström, Jonas Frisén

Publikováno v: Experimental neurology. 260

Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e0f5c84c7acb91b8a879d85bf89695
https://pubmed.ncbi.nlm.nih.gov/23376590