Pharmacogenomics in drug-induced cardiotoxicity: Current status and the future

Autor: Mo-Yun Li, Li-Ming Peng, Xiao-Ping Chen

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Drug-induced cardiotoxicity (DICT) is an important concern of drug safety in both drug development and clinical application. The clinical manifestations of DICT include cardiomyopathy, arrhythmia, myocardial ischemia, heart failure, and a series of c

Externí odkaz: https://doaj.org/article/f74432c315d3436484787947646d2609

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells

Autor: Peng Huang, Deng-jie Ouyang, Shi Chang, Mo-yun Li, Lun Li, Qian-ying Li, Rong Zeng, Qiong-yan Zou, Juan Su, Piao Zhao, Lei Pei, Wen-jun Yi

Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)

Abstract Background Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (TNBC) to chemotherapy

Externí odkaz: https://doaj.org/article/489510d0d2904ffa871365e7023d0202

Influence of GAS5/MicroRNA‐223‐3p/P2Y12 Axis on Clopidogrel Response in Coronary Artery Disease

Autor: Li‐Ming Peng, He Li, Mu‐Peng Li, Qi‐Lin Ma, Xiao‐Ping Chen, Xiao‐Lei Hu, Yin‐Xiao Du, Mo‐Yun Li, Ming‐Yu Song, Pei‐Yuan Song, Yan‐Ling Liu

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Dual antiplatelet therapy based on aspirin and P2Y12 receptor antagonists such as clopidogrel is currently the primary treatment for coronary artery disease (CAD). However, a percentage of patients exhibit clopidogrel resistance, in which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6da42e6c137cf8b04e4425713cb1c1c
http://europepmc.org/articles/PMC8751826

Tuning Parameters In Heuristics

Autor: Mo-Yun Lin, 林陌勻

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Optimization is one of the central themes in applied mathematics. Advancement of computing facilities has inspired new methodologies and possibility of new heuristics. It is well-known that parameter tuning affects performances of heuristic a

Externí odkaz: http://ndltd.ncl.edu.tw/handle/88630186204249840413