Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patterns

Autor: Mo-Quen Klinkert, Ayman Khattab, Mats Wahlgren, Victor Fernandez, Michaela Petter, Malin Haeggström

Publikováno v: Molecular and Biochemical Parasitology. 156:51-61

In order to avoid immune recognition in favor of a chronic infection, the malaria parasite Plasmodium falciparum has developed means to express clonally variant antigens at the surface of the infected erythrocyte (IE). Proteins of the var and rif mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3680e79484b4e28f187f80c304cf6d32
https://doi.org/10.1016/j.molbiopara.2007.07.011

Expression ofPlasmodium falciparum3D7 STEVOR proteins for evaluation of antibody responses following malaria infections in naïve infants

Autor: Mo-Quen Klinkert, Nadine Schreiber, Samuel Adjei, Jürgen May, Ayman Khattab, Michaela Petter, Florian Marks, Robin Kobbe

Publikováno v: Schreiber, N; Khattab, A; Petter, M; Marks, F; Adjei, S; Kobbe, R; May, J; Klinkert, M-Q (2008). Expression of Plasmodium falciparum 3D7 STEVOR proteins for evaluation of antibody responses following malaria infections in naïve infants. Parasitology, 135(2), pp. 155-67. London: Cambridge University Press 10.1017/S0031182007003794

SUMMARYClinical immunity toPlasmodium falciparummalaria develops after repeated exposure to the parasite. At least 2P. falciparumvariant antigens encoded by multicopy gene families (varandrif) are targets of this adaptive antibody-mediated immunity.

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https://doi.org/10.1017/s0031182007003794

Receptor-binding studies of the DBLγ domain of Plasmodium falciparum erythrocyte membrane protein 1 from a placental isolate

Autor: Gwladys Bertin, Grazyna Faure, Philippe Deloron, Mo-Quen Klinkert, Graham A. Bentley, Nicaise Tuikue Ndam, Alain Chaffotte, Cyril Badaut, Ayman Khattab

Publikováno v: Molecular and Biochemical Parasitology. 151:89-99

We have previously identified a number of DBLgamma domains in Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) transcripts obtained from placental parasite isolates, showing that they bind specifically to chondroitin sulfate A (CSA) (Kha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e93f857eb01c053117856f381f3dd38
https://doi.org/10.1016/j.molbiopara.2006.10.010

Additional file 2: Figure S2. of A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes

Autor: Bachmann, Anna, Scholz, Judith, JanßEn, Marthe, Mo-Quen Klinkert, Tannich, Egbert, Bruchhaus, Iris, Petter, Michaela

Solubilities of small VSAs analysed by fractionation studies. (A) Overview over selective permeabilization methods. Hypotonic lysis, saponin and streptolysin O differentially permeabilize the membrane system in infected erythrocytes allowing fraction

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Functional and Immunological Characterization of a Duffy Binding–Like–γ Domain fromPlasmodium falciparumErythrocyte Membrane Protein–1 Expressed by a Placental Isolate

Autor: Yu-Shan Chia, Nicaise Tuikue Ndam, Cyril Badaut, Ayman Khattab, Mo-Quen Klinkert, Graham A. Bentley, Philippe Deloron, Nadine Fievet, Sebastien Igonet

Publikováno v: The Journal of Infectious Diseases. 192:1284-1293

A recombinant Duffy binding-like (DBL)- gamma domain from a previously identified placental isolate, 732, was expressed by use of the baculovirus/insect cell system and was purified in milligram quantities. The recombinant protein binds specifically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66104ec1a37fbe9cc5410629612f18e
https://doi.org/10.1086/432918