Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mo Chou Chen-Hwang"'
Publikováno v:
Biochemistry. 46:7614-7624
The dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene is localized in human chromosome 21, and its overexpression has been associated with the learning and memory deficits of Down syndrome. DYRK1A contains a Y319XY321 motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fe1635c3cf6bcc6b9ea01bdb8b509b
https://doi.org/10.1021/bi700251n
https://doi.org/10.1021/bi700251n
Publikováno v:
Journal of Biological Chemistry. 277:17597-17604
The minibrain kinase (Mnbk)/dual specificity Yak 1-related kinase 1A (Dyrk1A) gene is implicated in the mental retardation associated with Down's syndrome. It encodes a proline-directed serine/threonine kinase whose function has yet to be defined. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8989c26711d89caf3cca8aa85b56ce
https://doi.org/10.1074/jbc.m111101200
https://doi.org/10.1074/jbc.m111101200
Publikováno v:
Archives of Biochemistry and Biophysics. 348:82-90
Synthetic deoxyoligonucleotides and phosphorothioate-capped oligonucleotides targeted to bases 112-128 of beta-amyloid peptide precursor (beta APP) mRNA were analyzed for their ability to reduce steady-state beta APP in COS-7 cells and in pMEP4-Rz1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ab4c09b1206b9cb15e9addbc03cfd8
https://doi.org/10.1006/abbi.1997.0383
https://doi.org/10.1006/abbi.1997.0383
Publikováno v:
Archives of Biochemistry and Biophysics. 348:157-162
The modification of E.coli elongation factor Ts (EF-Ts) by NEM and other sulfhydryl reagents inactivates the protein's ability to bind EF-Tu.GDP and to catalyze GDP exchange. The reactive residue was found to be Cys-22. Replacement of Cys-22 by Ser o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299c068d64aaeb2cdb6fad0350c531af
https://doi.org/10.1006/abbi.1997.0375
https://doi.org/10.1006/abbi.1997.0375
Autor:
Julia R. Currie, Henryk M. Wisniewski, Mo-Chou Chen-Hwang, Robert B. Denman, Marilyn Smedman, Anna Potempska, Narayan Ramakrishna, Richard Rubenstein, David Miller
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1355:248-258
In a search for Alzheimer beta-amyloid peptide precursor ligands, Potempska et al. (Arch. Biochem. Biophys. (1993) 304, 448) found that histones bind with high affinity and specificity to the secreted precursor. Because exogenous histones can be cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e655eb4319111387652305c4271e6019
https://doi.org/10.1016/s0167-4889(96)00139-5
https://doi.org/10.1016/s0167-4889(96)00139-5
Publikováno v:
Journal of Biological Chemistry. 271:8196-8202
We examined the effects of the Gly-60 to Ala mutation on the interaction of H-Ras with Ras GTPase activating protein (GAP), neurofibromin 1 (NF1), Raf-1, and ral guanine nucleotide dissociation stimulator (ralGDS), factors that interact with GTP-boun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc89c3c3f08fd748803cb128bb53f8bb
https://doi.org/10.1074/jbc.271.14.8196
https://doi.org/10.1074/jbc.271.14.8196
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f6d3d9f78c82b4e59ce85df0024baa
https://doi.org/10.1096/fasebj.21.6.a986
https://doi.org/10.1096/fasebj.21.6.a986
Publikováno v:
Biochemical and biophysical research communications. 351(4)
MNB/DYRK1A is a proline-directed serine/threonine kinase implicated in Down syndrome (DS). In an earlier screening, two proteins from adult rat brain, one 100 kDa and the other 140 kDa, were found to be prominently phosphorylated by the kinase. The 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9fa79640c8aa0c0f9832d1ac9aee13
https://pubmed.ncbi.nlm.nih.gov/17097615
https://pubmed.ncbi.nlm.nih.gov/17097615
Publikováno v:
Biochemistry. 45(39)
Minibrain kinase/dual-specificity tyrosine phosphorylation regulated kinase 1A (MNB/DYRK1A) is a proline/arginine-directed serine/threonine kinase implicated in the learning deficits of Down syndrome. Epigallocatechin-3-gallate (EGCG), the major tea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2671239c9e6b25809e713c3348bcda0e
https://pubmed.ncbi.nlm.nih.gov/17002300
https://pubmed.ncbi.nlm.nih.gov/17002300
Publikováno v:
The Journal of biological chemistry. 281(33)
Minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase (Mnb/Dyrk1A) is a proline-directed serine/threonine kinase encoded in the Down syndrome critical region of human chromosome 21. This kinase has been shown to phosphorylate dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ea6a943852717cdd52d340abe0e647
https://pubmed.ncbi.nlm.nih.gov/16733250
https://pubmed.ncbi.nlm.nih.gov/16733250